目的:探讨银离子藻酸盐敷料对不同类型手术切口的影响.方法:共选取患者100例,对照组50例,给予普通无菌敷料治疗.其中Ⅰ类切口(清洁切口)5例,Ⅱ类切口(清洁-污染切口)7例,Ⅲ类切口(污染切口)38例.实验组50例患者采用银离子藻酸盐敷料治疗,其中Ⅰ类切口(清洁切口)5例,Ⅱ类切口(清洁-污染切口)7例,Ⅲ类切口(污染切口)38例.比较两组患者的感染情况、愈合时间及视觉模拟评分(VAS),观察换药过程中的疼痛情况.结果:(1)Ⅰ类切口两组感染率均为0,组间无差异(P＞0.05);Ⅱ类、Ⅲ类切口对照组感染率明显高于观察组(P＜0.05);(2)Ⅰ类切口两组愈合时间差异不显著(P＞0.05);Ⅱ类、Ⅲ类切口愈合时间对照组明显长于观察组(P＜0.05);(3)Ⅰ类、Ⅱ类、Ⅲ类切口 VAS评分观察组均低于对照组(P＜0.05).结论:银离子藻酸盐敷料对伤口感染有显著效果,特别是在Ⅱ类、Ⅲ类切口中,不仅可以缓解疼痛,还可以降低伤口感染率,缩短伤口愈合时间.

目的:探讨银离子藻酸盐敷料对术后切口感染的应用效果.方法:将80例患者随机分为观察组和对照组,观察组在常规清创后应用银离子藻酸盐敷料,而对照组在常规清创后采用利凡诺敷料,观察两组患者的换药次数和切口完全愈合时间.结果:与对照组相比观察组的换药次数为(27±8.49)次,切口完全愈合时间为(16.58±6.57)d,明显缩短,二者相比有统计学意义(P＜0.05).结论:银离子藻酸盐敷料具有良好的控制伤口感染及促进伤口愈合的作用,使用银离子藻酸盐敷料处理感染伤口的换药能够缩短住院天数,减少换药次数及费用.

胃网膜淋巴管瘤是一种少见的良性肿瘤,我院普外科收治1例源自大网膜的淋巴管瘤,复习相关文献资料,探讨其临床病理特征、诊断及鉴别要点,以帮助更多医务工作者对该疾病的认识.

肾髓袢升支粗段(thick ascending limb,TAL)对NaCl的主动重吸收是髓质渗透梯度建立的直接动力,在尿液浓缩和稀释方面发挥重要作用.髓袢升支粗段钾通道在该段肾小管对NaCl主动重吸收过程中扮演重要角色,而TNF-α可对髓袢升支粗段钾通道的活性进行调节,进而影响NaCl的转运.

目的：探讨腹腔镜切除与内镜联合治疗对胃肠道小肿瘤采取微创治疗措施的临床治疗效果。方法：选取本院2015－05～2016－03接诊的80例胃肠道肿瘤患者作为研究对象，随机分为两组，每组40例，观察组患者予以腹腔镜切除联合内镜微创手术的治疗，对照组予以开腹切除手术。观察两组患者的手术治疗效果。结果：观察组患者的平均手术时间、术中出血量、胃肠道功能恢复时间以及平均住院时间均显著低于对照组，组间差异显著，具有统计学意义（P ＜0．05）；术后总不良反应发生率，观察组占比5％，对照组占比20％，观察组明显优于对照组，组间差异具有统计学意义（ P ＜0．05）。结论：对胃肠道小肿瘤患者行腹腔镜切除联合内镜的微创手术可大大缩短其治疗时间，具有较好的临床治疗效果，降低了不良病症的发生率，值得推广。

目的:探讨桂竹糖芥苷对肾髓袢升支粗段(thick ascending limb,TAL)管周膜50 pS钾通道活性的调控机制.方法:采用细胞贴附式膜片钳技术及免疫印迹技术测定桂竹糖芥苷对50 pS钾通道活性的调控机制.结果:桂竹糖芥苷可明显抑制50 pS钾通道的活性(P＜0.01);PKC阻断剂存在时,桂竹糖芥苷不再增加50 pS钾通道的活性(P＞0.05).结论:桂竹糖芥苷可能是通过激活PKC依赖途径抑制50 pS钾通道活性的.

Objective:To study the MMP-9expression in colorectal carcinoma,combined with the adjacent tissue and normal tissue expression,discuss MMP-9expression in colorectal carcinoma and the clinical pathological relationship.Methods:Immunohistochemistry(SP method)was adopted to detect the expression of CD44V6and RAB5ain 60cases of primary colon cancer,colon cancer and adjacent tissues(3~5cm)and normal tissue expression,combined with clinical pathological data in analysis.Results:The positive expression of MMP-9in gastric mucous adenocarcinoma,signet-ring cell carcinoma,3.0cm tissues and normal gastric mucosa tissues were 76.2%,83.3%,13.1%and 0%.The expression of MMP-9in gastric adenocarcinoma and signet ring cell carcinoma and paracancerous were high,which were significantly different from that of 3.0cm and normal tissues(P < 0.01);clinical and pathological analysis showed that:the expression of MMP-9had no relation to sex,age and tumor size(P>0.05),but closely related to the depth of invasion,lymph node metastasis and peritoneal implants.The positive expression rates of MMP-9were 90.1%in serosal invasion group;64.3%in noserous group;87.9%in lymph node metastasis;and 66.7%in no lymph node metastasis group.Conclusion:MMP-9was highly expressed in colorectal cancer compared with that in carcinoma and normal tissues,and there existed close contact between its expression and the degree of differentiation,lymph node metastasis and infiltration depth.

Objective:To study the effect of erysimosides on the renal tubular function and 50 pS potassium channel activities in the thick ascending limb(TAL) of rat kidney.Methods:The urine volume was measured by urethral intubation to determine the diuretic effect and the patch-clamp cell-attached recording technique was used to record the single potassium channel activities.Results:Erysimosides can increase the urine volume and decrease the 50 pS potassium channel activity of TAL.Conclusion:Erysimosides has a diuretic effect, which can be achieved by the mechanism of inhibiting the activity of basolateral 50 pS potassium channel.

腺苷是腺嘌呤核苷酸的代谢产物,生理条件下即存在于肾脏,其中95%-98%在细胞内,只有2%-5%在细胞外,参与肾内局部调节的是细胞外腺苷。腺苷通过腺苷受体发挥作用,对肾脏功能的调节具有重要意义。本文对肾内腺苷的调节功能进行了简要综述。

Objective To investigate the expression of EGF in hemangioma (HG) and vascular malformation (VM). Methods Between March 1998 and October 2005,92 patients including 72 patients with HG and 20 patients with VM were recruited in this study. Among of them,52 were female,and 40 were male. Patients' age ranged from 40 days to 13 years old with an average age of 1.6 years old. All the samples were collected from the resected tiddues, and were fixed by 10% neutral formaldehyde solution. Ten normal skin samples were taken as controls. H&E stain and immunohistochemical staining of EGF were performed on tissue sections. Results The expression of EGF was significantly increased in HG group, and decreased in VM group (P<0. 001 ). The EGF expression of HG group peaked in the proliferative phase, and decreased gradually in the involuting and involuted phases. The expression of EGF varied directly with the proliferation of vascular endothelial cells in HG patients (P <0. 001 ). Conclusions EGF is related to the proliferation and involution of HG but not VM. EGF promotes the proliferation of HG by affecting the proliferation of vascular endothelial cells.

蒲公英又称蒲公草、黄花地丁、黄花三七等,为菊科多年生草本植物.其分布广泛,药食两用,具有清热解毒、消肿散结和利尿通淋之功效.

凡实行胆总管切开探查术者,均需放置T管.其目的是为了引流胆汁,支撑胆道,降低胆道压力,减轻胆道因手术创伤而造成的水肿、炎症,并防止胆汁外漏,有利于胆道愈合,防止胆道狭窄、梗阻等并发症的发生.

近年来,随着静脉留置针在临床的广泛应用,越来越多的患儿家长为减轻孩子因反复静脉穿刺而造成的痛苦,要求为孩子使用静脉留置针.

先天性肥厚性幽门狭窄(congenital hypertrophic pyloric stenosis,CHPS)是幽门环肌增生肥厚,使幽门腔狭窄所引起的胃输出道不全性梗阻,为新生儿常见病,我国的发病率为1‰,男性多于女性,以往诊断依靠临床和X线钡餐(GI)检查,我们对16例临床疑诊CHPS的患儿进行了彩超检查,结合GI及手术证实者对比分析,现报道如下.

为了明确诊断,在患儿入院后采取一些必要的辅助检查,如CT,胃肠透视,X线拍片,B超等.因为小儿恐惧,躁动影响检查效果,不利于治疗,因此检查前给患儿口服或肌注适量的镇静剂对小儿进行辅助检查起到很好的疗效.

Objective To understand the relationship between basic fibroblast growth factor(bFGF) and hemangioma(H)and vascular malformation(VM).Methods The expression of bFGF of the tissue sections of 72 cases with H and 20 VM were examined with SP immunohistochemistry.Results The expression of bFGF was significantly higher in the tissue of H and lower in the tissue of VM(P0.01).There were significantly different expressions of bFGF in H among proliferative,early degenerative and completed degenerative phase:the higher the degree of proliferation of vascular endothelium ,the higher expression of bFGF(P0.05).Conclusion bFGF was definitely related to the proliferation and degeneration of H,but was not remarkably related to VM.

血管瘤是一种良性血管增生性疾病,是婴儿中最常见的肿瘤.血管内皮生长因子(VEGF)是一种多肽类血管形成因子,有促进内皮细胞增殖的作用.本文采用免疫组织化学方法,测定VEGF在血管瘤和血管畸形中的表达,探讨VEGF与血管瘤及血管畸形的关系.

目的：了解肥大细胞与血管瘤及血管畸形的关系。方法：采用甲苯胺蓝染色法，对72例血管瘤和20例血管畸形组织切片的肥大细胞进行测定。结果：肥大细胞在血管瘤组织中高表达，而在血管畸形组织中低表达(P＜0.01) 。在血管瘤增殖期，退化早期和退化完成期三者之间，肥大细胞的表达存在着差异。血管内皮细胞增生程度越高，肥大细胞的数目越多(P＜0.05)。结论：提示肥大细胞与血管瘤的增生及退化有关，而与血管畸形无明显关系。