肝癌是消化系统发生率最高的恶性肿瘤之一,全球发病率每年一百万,自90年代以来原发性肝癌已上升为我国恶性肿瘤的第二位;全球每年约有31万患者、中国每年有13万患者死于肝癌,占全球肝癌死亡总数的42%[1,2].目前对它的治疗仍首推早期手术切除.然而,仅有10～20%的肝癌患者可以接受以手术为主的综合治疗.对晚期肝癌,因肿瘤较大,多发结节并常伴有肝硬变、肝功不全等而无法手术.故局部非手术疗法更为重要.近些年来临床应用的经皮肝穿灶内酒精注射、激光、射频、微波等局部疗法已获一定疗效[2,3].但它们都需在肝癌组织内插入穿刺针,增加了针道转移、出血、胆漏的危险;治疗范围不易控制,治疗过程缺乏有效监控,不能确保肿瘤完全破坏;也因此需反复进行,疗期较长;且对较大肿瘤治疗较困难,使其临床应用有一定的局限性[4,5].

Objective To find a rational protocol for the treatment of patients with advanced digestive cancers.Methods Thirty-eight patients with advanced digestive cancers were studied retrospectively,among whom there were 6 cases of esophageal cancer,17 of stomach cancer and 15 of colorectal cancer with pathological evidence.Thirty-five patients presented obstruction;28 complained of pain;10 confronted bleeding;18 developed jaundice.All patient were with metastasis and in malnutrition.They were given palliative treatment and terminal solicitude.Results The life quality was improved with all the symptoms ameliorated.The survival time was prolonged.Conclusions As for each patient with advanced cancer,a rational therapy protocol should be applied individually.The modern medicine combined with traditional Chinese medicine should be considered on the condition of no damage to the immune function.

Objective Toinvestigate the effect of changes of sex hormones in patients with gastrointestinal cancer on diagnosis and treatment. Methods Serum estrogen level (SEL) and serum testosteronelevel(STL) were detected in 58 healthy subjects as control. Results STLwas significantly lowerin male and female cancer cases before operation than thatin benign and control group ( P 0-01) ,and increased significantly after operation ( P 0-01) .SELwas significantly higherin male cancercases before operation thanthatin benign and controlgroup ( P 0-05) ,and significantly decreased after operation ( P 0-05) . SEL was significantly lower in female cancer cases before operation than that in benign and control group ( P 0-05) , and increased significantly after operation ( P 0-01) . STLand SELhad no difference between benign and control group ,pre and post operation of benign group . Conclusion Itis significantto detect the level of serum sex hormonefor the diagnosis and treatment of gastrointestinalcancer.