P P Savani University is a private university located in Dhamdod, Kosamba, Surat district, Gujarat, India. The university was established in 2017 through the Gujarat Private Universities (Amendment) Act, 2017, which was passed in March 2017 and also established Swarnim Startup & Innovation University, Karnavati University and Indrashil University. The university is accredited by NAAC B++. The first convocation was held in 2020.
The phenomenon photocatalysis in quantum dots (QDs), has attracted interest in utilising their potential to tackle some of the world’s most urgent problems, such as the energy crisis, environmental problems, and illnesses like cancer. Innovations in photocatalysis are greatly aided by the special phenomenon of quantum confinement and the electrical properties of QDs. Strategic structural manipulation of quantum dots through doping or functionalisation has opened new possibilities to modify their quantum electronic structures for improved photocatalytic selectivity. The incorporation of dopants and co-dopants in QDs and their impact on the optical properties are highlighted. This review focuses different mechanistic action of photocatalytic QDs. The effect of both dopants and co-dopants was analysed in detail to account the precision and versatility. Finally, the various applications of the quantum dots are discussed.
Many potent anticancer agents suffer from poor water solubility, limiting their industrial translation into effective formulations. Although single micellar systems have been explored to address this issue, they often exhibit low stability and encapsulation efficiency. To overcome these limitations, this study developed and characterized PEG-based mixed micelles composed of Gelucire® 48/16 and Tetronic® 1304 (T1304), aiming to improve the solubilization and cytotoxicity of a model lung cancer drug, quercetin (QCT). The micelles were extensively analysed using cloud point (CP), small-angle neutron scattering (SANS), and high-performance liquid chromatography (HPLC) techniques. SANS confirmed that Gelucire® 48/16 formed spherical or ellipsoidal micelles depending on composition with T1304. Micellar growth and improved drug encapsulation are noticed in saline conditions through the salting-out effect. In vitro cytotoxicity studies in lung epithelial adenocarcinoma (A549) cells demonstrated that Gelucire® 48/16 micelles enhanced the cytotoxic effect of QCT, while T1304 provided controlled release, with the mixed system offering intermediate modulation. The results indicate that mixed micellar systems showed a potential cytotoxic effect via increased ROS generation and DNA damage, ultimately damaging cancer cells. Additionally, our findings support a practical and commercially viable approach for enhancing the solubility and therapeutic efficacy of hydrophobic drugs, which can be further useful in various biomedical applications, such as healthcare formulations and drug delivery.
Mental health challenges among employees have become an increasingly critical issue in modern organizational environments due to rising workloads, technological disruptions, and evolving workplace structures. Work stress, if not managed effectively, can significantly impact employee well-being, productivity, and long-term organizational sustainability. At the same time, organizational culture plays a crucial role in shaping how employees perceive stress, seek support, and maintain psychological resilience. This study presents a multidisciplinary health systems analysis of the relationship between mental health, work stress, and organizational culture. The proposed framework integrates insights from occupational psychology, public health, organizational behavior, and management sciences to examine how structural workplace factors influence mental health outcomes. The research adopts a mixed-methods approach combining surveybased psychological assessments, organizational culture analysis, and statistical modeling of stress-related indicators across multiple organizations. Findings demonstrate that supportive organizational cultures characterized by transparent communication, participative leadership, and work-life balance policies significantly reduce psychological distress among employees. Conversely, rigid hierarchical cultures with high performance pressure and limited emotional support tend to amplify workplace stress and burnout risks. The study further identifies key organizational determinants of mental health outcomes, including workload distribution, managerial support, peer relationships, and institutional policies. The results emphasize the importance of integrating mental health management strategies into organizational systems rather than treating employee well-being as an isolated human resource issue. By adopting a health systems perspective, organizations can design sustainable interventions that enhance employee resilience, reduce burnout, and improve overall workplace productivity. The findings contribute to the growing interdisciplinary discourse on occupational health and provide practical recommendations for organizations seeking to develop healthier and more resilient work environments.
This study utilized a green and efficient Biginelli multicomponent process to synthesize several types of novel discovered Dihydropyrimidinone (DHPMs), Dihydropyrimidinthione (DHPMTs) and 2-amino Dihydropyrimidines (2A-DHPMs) derivatives. DIAION SK104 acid resin served as an eco-friendly catalyst in Water to condense substituted aromatic aldehydes, (3-ketoesters and urea/thiourea/guanidine. This approach yielded impressive results (85-94%). The NMR studies of 1H and 13C confirmed the structural integrity of all produced molecules. To evaluate the potential biological relevance of the synthesized compounds, in silico molecular docking studies were performed against selected biological targets. Several derivatives exhibited significant binding affinities, with docking scores ranging from approximately (-7.4) to (-7.8) kcal/mol, suggesting strong ligand-protein interactions. Notably, certain derivatives promising binding interactions against CYP51, where compounds such as 7CC and 7AA exhibited docking scores up to (-9.24) kcal/mol, outperforming the standard antifungal drug fluconazole. Beyond docking, Density Functional Theory (DFT) calculations probed the electronic properties of the synthesized molecules. The HOMO-LUMO energy gap, molecular electrostatic potential and optimized geometries provided insights into the chemical reactivity and stability of the compounds. The highly reactive compound 7AA exhibited a minimal energy gap of -0.0924 Eh, while the kinetically stable compound 6AA displayed a maximum gap of -0.1651 Eh. Similarly, compound 3BB verified a minimized gap of -0.1364 Eh. These energy gap values, alongside molecular electrostatic potential and optimized geometries, provided comprehensive insights into the compounds' thermodynamic profiles. Finally, molecular dynamics (MD) simulation studies verified the stability of the ligand-protein complexes under physiological conditions.
