Many people engagingin medical scienceasked me,"You’ve beenworking on the exploration of Holistic Integrated Medicine（HIM）for quite awhile.What is the progressyou have made in your research?Have you got your article published?May I beyour first reader?"
Objective To study the effect of tofacitinib on tendon sheath thickness and synovial thickness in patients with rheumatoid arthritis.Methods A total of 74 patients with rheumatoid arthritis diagnosed and treated in our hospital from July 2021 to July 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 37 patients in each group.The control group was treated with methotrexate+leflunomide,and the observation group was treated with methotrexate+tofacitinib.The clinical efficacy,clinical symptom improvement indicators(joint swelling number,joint tenderness number,morning stiffness time),pain(VAS)score,DAS28 score,tendon sheath and synovial thickness,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(94.59％)was higher than that in the control group(81.08％)(P＜0.05).The number of joint swelling,the number of joint tenderness relief and the proportion of morning stiffness relief in the observation group were higher than those in the control group(P＜0.05).After treatment,the VAS score and DAS28 score of the two groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group(P＜0.05).After treatment,the thickness of tendon sheath and synovial membrane in the two groups were smaller than those before treatment,and those in the observation group were smaller than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.41％,which was lower than 13.51％in the control group(P＜0.05).Conclusion Tofacitinib has a good clinical effect in the treatment of patients with rheumatoid arthritis,which can reduce the clinical symptoms and pain scores of patients,and plays an important role in improving the thickness of tendon sheath and synovium.High-frequency color Doppler ultrasound can be used to evaluate the clinical efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis.
Objective To observe the effect of oxytocin combined with motherwort injection on postpartum hemorrhage and coagulation function in elderly parturient women.Methods Sixty elderly parturient women who gave birth in our hospital from January 2020 to June 2022 were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with oxytocin,and the observation group was treated with motherwort injection on the basis of the control group.The incidence of postpartum hemorrhage,bleeding volume at different time periods,coagulation function indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FBG)],duration of uterine contraction and lochia,uterine involution and incidence of adverse reactions were compared between the two groups.Results The incidence of bleeding in the observation group was 6.67％,which was lower than 16.67％in the control group(P＜0.05).The amount of bleeding at 2 and 24 hours after delivery in the observation group was less than that in the control group(P＜0.05).APTT and PT in the observation group were lower than those in the control group,and FBG was higher than that in the control group(P＜0.05).The duration of uterine contraction in the observation group was longer than that in the control group,and the duration of lochia was shorter than that in the control group(P＜0.05).The vertical height of the uterine fundus and the midpoint of the upper edge of the pubic symphysis in the observation group was lower than that in the control group at 2 and 6 days after delivery(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).Conclusion Oxytocin combined with motherwort injection can effectively prevent postpartum hemorrhage in elderly parturient women,reduce the amount of bleeding within 24 hours after delivery,improve coagulation function to a certain extent,promote uterine contraction,shorten the duration of lochia,and reduce the incidence of adverse reactions.It has good application effectiveness and safety.
Objective To study the effect of rabeprazole combined with Lanqin oral solution in the treatment of chronic pharyngitis and its effect on clinical symptoms,inflammatory factors and immune function.Methods A total of 74 patients with chronic pharyngitis who were admitted to the Department of Otorhinolaryngology,Branch of Tianjin Third Central Hospital from June 2021 to June 2022 were selected and divided into control group(37 patients)and observation group(37 patients)by random number table method.Both groups were treated with budesonide atomization inhalation.On this basis,the control group was treated with Lanqin oral solution,while the observation group was treated with rabeprazole combined with Lanqin oral solution.The therapeutic effect,clinical symptoms,symptom relief time,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],immune function[peripheral blood T lymphocyte subsets(CD4+,CD8+,CD4+/CD8+)]were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.59％,which was higher than 78.38％in the control group(P＜0.05).The symptom scores(throat itching,hoarseness,foreign body sensation,pharyngeal obstruction)in the observation group were lower than those in the control group(P＜0.05).The symptom relief time(throat itching,hoarseness,foreign body sensation,pharyngeal obstruction)in the observation group was shorter than that in the control group(P＜0.05).The levels of TNF-α and IL-6 in the observation group were lower than those in the control group(P＜0.05).CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P＜0.05).Conclusion Rabeprazole combined with Lanqin oral solution is effective in the treatment of chronic pharyngitis,which can improve the clinical symptoms of patients,accelerate the relief of symptoms,down-regulate inflammatory factors in the body,and promote the improvement of immune function.
Objective To explore the related risk factors of rupture of very small intracranial aneurysms(VSIA),and to provide guidance for the clinical management of unruptured intracranial microaneurysms.Methods A total of 99 patients of single very small intracranial aneurysms at Calmette Hospital Affiliated to Kunming Medical University from January 2016 to November 2021 were continuously included in the study.They were divided into ruptured group(n=48)and non-ruptured group(n=51)according to whether or not they ruptured.The clinical features,tumor location,shape and morphological parameters of the patients were retrospectively analyzed.Independent sample t test orx2test was used to analyze the significance of these factors.Multivariate logistic regression analysis was further performed on the statistically significant factors in the univariate analysis.The receiver operating characteristic curve was used to analyze the optimal threshold of each parameter to predict the rupture of microaneurysms.Results There were significant differences in aneurysm location,morphology,inflow angle,aneurysm angle,aspect ratio,volume to neck ratio,diameter-width ratio,size ratio,hypertension history and smoking history between the ruptured group and the non-ruptured group(P＜0.05).Multivariate Logistic regression analysis showed that smoking history,inflow angle,diameter-width ratio,volume to neck ratio and shape were independent risk factors for rupture of microaneurysms(P＜0.05).The ROC curve showed that the maximum area under the curve of the inflow angle was 0.864,which was the most accurate to evaluate whether the VSIA was ruptured.Conclusion Very small intracranial aneurysm with large inflow angles,diameter-width ratio,volume to neck ratio,irregularities in the aneurysm,and location in the anterior communicating artery are considered to be at high risk of rupture,and aggressive surgical intervention is recommended if conditions warrant.For patients with a history of hypertension and smoking,it is recommended to control blood pressure well,quit smoking,undergo regular digital subtraction angiography review,and timely surgical intervention if aneurysm morphology changes.
Objective To study the diagnostic value of multi-slice spiral CT scanning and reconstruction technique in acute abdomen caused by ureteral calculi.Methods From April 2020 to October 2022,70 patients with acute abdomen caused by ureteral calculi diagnosed and treated in our hospital were selected as the research objects.All patients underwent ultrasound,multi-slice spiral CT examination and reconstruction techniques.The detection rate of different examination methods,the detection rate of different examination methods for different diameters and different parts of stones,the diagnostic efficiency of different examination methods(sensitivity,specificity)and the CT imaging characteristics of acute abdomen caused by ureteral calculi were observed.Results The detection rate of multi-slice spiral CT examination and reconstruction technology was 98.57％,which was higher than 82.86％of ultrasound examination(P＜0.05).The detection rate of stone diameter＜6 mm by multi-slice spiral CT examination and reconstruction technique was higher than that by ultrasonography(P＜0.05),but there was no significant difference in the detection rate of stone diameter 6-10 mm and＞10 mm by different examination methods(P＞0.05).The detection rate of middle and lower ureteral calculi by multi-slice spiral CT examination and reconstruction technique was higher than that by ultrasonography(P＜0.05),but there was no significant difference in the detection rate of upper ureteral calculi between different examination methods(P＞0.05).The sensitivity and specificity of multi-slice spiral CT examination and reconstruction technique in the diagnosis of acute abdomen caused by ureteral calculi were higher than those of ultrasonography(P＜0.05).The CT images of acute abdomen caused by ureteral calculi mainly showed high density shadow in axial position,some of which were round and irregular.After the reconstruction technique,the ureteral calculi were round,columnar,and multiple stones were beaded.Conclusion Multi-slice spiral CT scanning and reconstruction technology can improve the diagnostic accuracy of acute abdomen caused by ureteral calculi,and has high diagnostic efficiency,especially when the stone diameter is less than 6 mm,the middle and lower ureteral calculi,which can be used as an ideal way to diagnose acute abdomen caused by ureteral calculi.
This article reviews the research progress of active peptide derived from animal traditional Chinese medicine in recent years.It provides a new idea for the development and utilization of active peptide from animal traditional Chinese medicine.With more than 40 animal traditional Chinese medicines in the 2020 edition of the Chinese Pharmacopoeia and commonly used in clinic as the key words,we have reviewed and collated relevant literature reports at home and abroad in recent years,the pharmacological effects of active peptides from animal traditional Chinese medicine on anticoagulation,regulation of Blood Lipid,anti-tumor,anti-oxidation and protection of liver are expounded.The relative molecular weight of active peptides is generally less than 5 KDa,which is easier to be absorbed by human body than protein,macromolecular peptides and amino acids.Meanwhile,it has many kinds of physiological activities,which indicates that the active peptides of animal traditional Chinese medicine have high research and development value.
Objective To study the effect of holistic nursing combined with comprehensive nursing of traditional Chinese medicine on health behavior,pain degree and disease recurrence in patients with chronic pelvic inflammatory disease.Methods A total of 78 patients with chronic pelvic inflammatory disease diagnosed and treated in our hospital from January 2020 to July 2022 were included in the study.They were divided into control group(n=39)and observation group(n=39)by random number table method.The control group was treated with routine nursing intervention,and the observation group was treated with holistic nursing combined with traditional Chinese medicine comprehensive nursing intervention.The health behavior score,clinical symptom disappearance time,pain score,disease recurrence rate and nursing satisfaction were compared between the two groups.Results The health behavior score of the observation group after intervention was higher than that of the control group(P＜0.05).The disappearance time of lower abdominal pain,lumbosacral pain and abnormal vaginal discharge in the observation group was shorter than that in the control group(P＜0.05).The pain score of the observation group after intervention was lower than that of the control group(P＜0.05).After 3 months of follow-up,the recurrence rate of the observation group was lower than that of the control group(P＜0.05).The nursing satisfaction of the observation group was higher than that of the control group(P＜0.05).Conclusion Holistic nursing combined with comprehensive nursing of traditional Chinese medicine can improve the health behavior of patients with chronic pelvic inflammatory disease,reduce the degree of pain,reduce the recurrence rate of the disease,shorten the disappearance time of clinical symptoms,and patients have higher satisfaction with nursing.
Objective To study the mechanism and effect of transcranial repetitive magnetic stimulation on cerebral blood perfusion regulation in patients with chronic insomnia and anxiety.Methods From January 2022 to January 2023,70 patients with chronic insomnia and anxiety admitted to the People's Hospital of Shapingba District,Chongqing City were selected and grouped by random lottery.Among them,35 patients were included in the control group and treated with drugs.The study group also included 35 patients who underwent transcranial repetitive magnetic stimulation combined with drug therapy.The scores of Beck Depression Scale,Hamilton Anxiety Scale,Pittsburgh Sleep Index Scale,Epworth Sleepiness Scale,cerebral blood flow velocity,phase difference between left and right cerebral hemispheres,skin sympathetic response latency and amplitude were compared between the two groups.Results The scores of Beck Depression Scale,Hamilton Anxiety Scale,Pittsburgh Sleep Index Scale and Epworth Sleepiness Scale in the study group were better than those in the control group,and the differences were statistically significant(P＜0.05).The cerebral blood flow velocity of the control group was lower than that of the study group,and the phase difference between the left and right cerebral hemispheres was higher than that of the study group,the differences were statistically significant(P＜0.05).The skin sympathetic response latency and amplitude of the study group were lower than those of the control group,and the difference was statistically significant(P＜0.05).The insomnia index score of the study group was better than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Repetitive transcranial magnetic stimulation can improve the sleep quality of patients with insomnia and anxiety,regulate blood flow,improve neuronal metabolic activity,and alleviate insomnia and anxiety symptoms,which is an effective non-drug treatment strategy.
Objective To observe the effect of different microbiological tests on candida infection in vagina.Methods A total of 63 patients with vaginitis diagnosed and treated in our hospital from January 2021 to January 2023 were selected as the research objects.The culture identification method was used as the gold standard.According to the detection methods,they were divided into chromogenic method(n=21),fungal fluorescence staining method(n=21),and Gram staining method(n=21).The results of different test methods,the detection rate of Candida were compared,and the ROC curve were used to analyze the diagnostic efficacy of Candida infection.Results The results of Candida infection in vagina by fungal fluorescence staining were significantly different from those of positive and negative test results by chromogenic method and Gram staining method(P＜0.05).The detection rate of candida in the vagina by fungal fluorescence staining was 90.48％,which was higher than 66.67％by chromogenic method and 71.43％by Gram staining method(P＜0.05).ROC curve analysis showed that the sensitivity and specificity of fungal fluorescence staining in the diagnosis of candida infection were higher than those of chromogenic method and Gram staining method(P＜0.05).The area under the ROC curve of fungal fluorescence staining,Gram staining and chromogenic method were 0.93,0.73,0.74,respectively.The clinical diagnostic value of fungal fluorescence staining was higher.Conclusion Fungal fluorescence staining has a significant effect on the detection of candida infection in the vagina,which can improve the positive detection rate and provide a reliable reference for clinical treatment.It is worthy of clinical application.
In order to promote the construction of the three centers for chest pain,stroke and trauma,speed up the construction of the regional cardio-cerebrovascular disease emergency treatment system and trauma emergency treatment system,according to the relevant requirements of chest pain,stroke and trauma centers,the accurate and effective information construction work of the three centers should be completed.This paper proposes to construct the management system architecture of the three centers by means of information means,so as to realize the information sharing before,after and in hospital,and construct the whole-course management system of cardiovascular and cerebrovascular diseases,so as to improve the medical treatment ability of acute cardiovascular and cerebrovascular diseases and trauma.
Objective To study the mechanism of Bugu Yisui decoction in the treatment of osteoporosis rats.Methods A total of 60 rats were used to establish a rat model of osteoporotic fracture.They were divided into test group,positive control group and model group by random number table method,with 30 rats in each group.The test group was given Bugu Yisui decoction by gavage,the positive control group was given testosterone by gavage,and the model group was given equal volume of distilled water.Another 20 rats were selected as the blank group.The bone mineral density of the left tibia fracture site of each group was compared,and the morphological changes of bone tissue were observed.The changes of prostaglandin E2 and prostacyclin in serum,gene and protein expression in tibia tissue were detec ted.Results The tibial tissue status of the model group was worse than that of the blank group,and the histopathological changes were serious.Compared with the blank group,PGE2 and PGI2 in the serum of the model group were increased(P＜0.05).Compared with the model group,the contents of serum PGE2 and PGI2 of rats in the test group were decreased(P＜0.05).There was no significant difference in serum PGE2 and PGI2 levels between the positive control group and the test group(P＞0.05).Compared with the blank group,the expression of BMP2 and TIMP1 protein in the tibial tissue of the model group decreased,and the expression of TIMP1 protein in the tibial tissue of the test group increased compared with the model group(P＜0.05).Compared with the positive control group,the protein expression was increased(P＜0.05).Compared with the model group,the expression of BMP2 protein in the tibia tissue of the rats in the test group was increased(P＜0.05),and there was no significant difference compared with the positive control group(P＞0.05).Compared with the blank group,the expression of BMP2 and TIMP1 genes in the tibia tissue of the model group decreased,and the difference was statistically significant(P＜0.05).The gene expression of BMP2 and TIMP1 in tibia tissue of rats in the test drug group was higher than that in the model group and the positive control group(P＜0.05),and the gene expression of BMP2 and TIMP1 in tibia tissue of rats in the positive control group was higher than that in the model group(P＜0.05).Conclusion Bugu Yisui decoction has a certain therapeutic effect on osteoporosis rat model,and the related mechanism may be related to its inhibition of serum PGE2/PGI2 level,promotion of BMP2/TIMP1 gene and protein expression,and improvement of bone quality.
Objective To study the clinical efficacy of somatostatin and ulinastatin in the treatment of acute pancreatitis(AP)and its effect on gastrointestinal function.Methods A total of 72 patients with AP admitted to the Department of Emergency and Critical Care Medicine of Nanchang Third Hospital from October 2021 to October 2022 were selected and divided into control group(36 patients)and observation group(36 patients)according to the random number table method.The control group was treated with ulinastatin,and the observation group was treated with somatostatin and ulinastatin.The clinical efficacy,biochemical indexes[blood amylase(AMS),white blood cell(WBC),C-reactive protein(CRP)],bedside index of severity in acute pancreatitis(BISAP),gastrointestinal function score,recovery time(abdominal pain disappearance time,defecation time,AMS recovery time,hospitalization time)were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44％,which was higher than 77.78％in the control group(P＜0.05).After treatment,the levels of AMS,WBC and CRP in the two groups were lower than those before treatment,and the levels of AMS,WBC and CRP in the observation group were lower than those in the control group(P＜0.05).After treatment,the BISAP and gastrointestinal function scores of the two groups were lower than those before treatment,and the BISAP and gastrointestinal function scores of the observation group were lower than those of the control group(P＜0.05).The disappearance time of abdominal pain,defecation time,AMS recovery time and hospitalization time in the observation group were shorter than those in the control group(P＜0.05).Conclusion Somatostatin combined with ulinastatin is effective in the treatment of AP,which can effectively improve the patient's condition and gastrointestinal function,down-regulate the level of inflammatory injury markers in vivo,and accelerate its clinical recovery.
Objective To observe the clinical efficacy of laparoscopic cholecystectomy in the treatment of acute calculous cholecystitis,and the changes of inflammatory factors and serum amylase levels after operation.Methods A total of 80 patients with acute calculous cholecystitis diagnosed and treated in our hospital from January 2021 to March 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 40 patients in each group.The control group was treated with traditional open surgery,and the observation group was treated with laparoscopic cholecystectomy.The pain scores at different time periods,postoperative inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]levels,changes in serum amylase levels,postoperative traumatic stress response indicators[cortisol(Cor),norepinephrine(NE)],and incidence of complications were compared between the two groups.Results There was no significant difference in pain score at 2 h after operation(P＞0.05).The pain scores at 6,12 and 24 h after operation were lower than those in the control group(P＜0.05).At 3 days after operation,the levels of CRP,IL-6,IL-8 and TNF-α in the two groups were higher than those before operation,but those in the observation group were lower than those in the control group(P＜0.05).At 3 days after operation,serum amylase,Cor and NE in the two groups were higher than those before operation,but those in the observation group were lower than those in the control group(P＜0.05).The incidence of complications in the observation group was 7.50％,which was lower than 17.50％in the control group(P＜0.05).Conclusion Laparoscopic cholecystectomy is effective in the treatment of acute calculous cholecystitis,which can reduce the postoperative inflammatory stress response,reduce the fluctuation of serum amylase,Cor,NE and the incidence of complications,with ideal clinical application effectiveness and safety.
Objective To observe the clinical efficacy of Internet+continuous nursing under the mode of psycho-cardiology in patients with heart failure patients with reduced ejection fraction.Methods A total of 50 patients with heart failure with reduced ejection fraction who were treated in our hospital from July to August 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 25 patients in each group.The control group was given routine nursing,and the observation group was treated with Internet+continuous nursing under the model of psycho-cardiology.The anxiety score,depression score,quality of life score(SF-36),medication compliance,improvement of cardiac function and incidence of cardiovascular adverse events were compared between the two groups.Results The scores of anxiety and depression in the two groups were lower than those before intervention,and those in the observation group were lower than those in the control group(P＜0.05).The scores of physiological function,physiological function,physical pain,general health,energy,social function,emotional function and mental health in the observation group were higher than those in the control group(P＜0.05).There was no significant difference in medication compliance score between the observation group and the control group at 1 month after intervention(P＞0.05).The medication compliance scores at 2 and 4 months after intervention were higher than those in the control group(P＜0.05).The left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVDD)in the two groups were higher than those before intervention,and those in the observation group were higher than those in the control group(P＜0.05).The incidence of cardiovascular adverse events in the observation group was 4.00％,which was lower than 16.00％in the control group(P＜0.05).Conclusion Internet+continuous nursing under the model of psycho-cardiology can promote the improvement of cardiac function in patients with heart failure patients with reduced ejection fraction,improve their medication compliance and the quality of life,reduce anxiety and depression scores,and reduce the incidence of cardiovascular adverse events.
Objective To investigate the development status and research hotspot of Danggui Sini decoction,in order to provide reference for related research.Methods The related research literatures of Danggui Sini decoction collected by CNKI,VIP,Wanfang Data and CBM database from the establishment of the database to December 31,2022 were searched by computer.NoteExpress3.6 software was used to merge and deduplicate the data,and then CiteSpace5.7.R5 software was used to draw the knowledge map of authors,institutions and keywords for analysis.Results There were 1970 literatures included,and the number of published papers on Danggui Sini decoction showed an overall trend of fluctuation and increase.The number of published papers in source journals was Journal of New Chinese Medicine(74 articles).The authors who published more articles were ZHAO Guo-ping(8 articles),ZHANG Bo-li(6 articles)and MA Hong-mei(6 articles).Guang'anmen Hospital of China Academy of Chinese Medical Sciences published the most papers.High-frequency keywords included"modified Danggui Sini decoction""diabetic peripheral neuropathy""Treatise on Cold-Attack""clinical application",etc.Conclusion The research hotspots of Danggui Sini decoction mainly focus on the related fields such as prescription research,clinical application and experimental research.Exploring the mechanism of related pathways based on network pharmacology and other methods is the research trend in this field.
Objective To screen the dysregulated miRNAs in intracranial aneurysms(IA)by next-generation sequencing and bioinformatics methods,and to explore their possible biological functions.Methods The differentially expressed miRNAs between IA and superficial temporal artery tissues were screened in the public data set numbered GSE66239 in the GEO database.In addition,IA tissues and superficial temporal artery tissues of patients with rupture and hemorrhage of intracranial aneurysm who underwent craniotomy aneurysm clipping in Hongqi Hospital Affiliated to Mudanjiang Medical University from 2021 to 2022 were collected for miRNA sequencing analysis to verify the results of the public data set.The target genes of miRNAs were predicted by miRDB database and miRWalk database.The functional enrichment analysis of miRNA target genes was performed using the R software package clusterProfiler.The protein-protein interaction network(PPI)analysis was performed using the STRING database,and visualized by Cytescape software to extract the core genes in the PPI network.Based on the transcriptome data in the GSE122897 dataset,single-sample gene set enrichment analysis(ssGSEA)was used to evaluate the infiiltration scores of 16 immune cells and 12 immune status scores in the immune.Results In the GSE66239 dataset,54 miRNAs were up-regulated and 1010 miRNAs were down-regulated in IA tissues compared with normal superficial temporal artery tissues.In clinical specimens,compared with normal superficial temporal artery tissue,23 miRNAs were up-regulated and 29 miRNAs were down-regulated in IA tissue.hsa-miR-3176,hsa-miR-1246 and hsa-miR-539-3P showed low expression in IA tissues in GSE66239 dataset and clinical specimens.And 738 and 116 hsa-miR-539-3P-targeted mRNAs were predicted in the miRDB database and the miRWalk database,respectively,and 9 targeted mRNAs were obtained after intersection.Correspondingly,hsa-miR-1246 obtained 407 and 711 targeted mRNAs in the miRDB database and the miRWalk database,respectively,and 34 mRNAs were obtained after intersection.hsa-miR-3176 obtained 482 and 3486 targeted mRNAs in the miRDB database and the miRWalk database,respectively,and 187 mRNAs were obtained after intersection.Functional enrichment analysis showed that the target genes of the above three miRNA were mainly related to the MAPK signaling pathway,FGF pathway,CD8+T cell receptor downstream pathway,S1P pathway,G protein signaling pathway,ERBB signaling pathway,interleukin signaling,neurotransmitter release and other pathways.The PPI network composed of hsa-miR-3176,hsa-miR-1246 and hsa-miR-539-3P target genes contained 121 nodes and 117 interactions.Among them,ERBB4,FGF1,CBL,GNAO1,GNAZ,PTPRT,KCNB1,KCNJ2,POLR2J2 and CD247 are the top 10 core genes in the PPI network,and these core genes were regulated by hsa-miR-3176.Functional enrichment analysis showed that these core genes were related to ERBB signaling pathway,Rap1 signaling pathway,MAPK signaling pathway,PI3K-AKT signaling pathway,CXCR4 signaling pathway,CXCR3 signaling pathway,CD8+T cell receptor signaling pathway and other biological processes.Compared with superficial temporal artery tissue,the infiltration of CD8+T cells,macrophages,mast cells,neutrophils,helper T cells,Thl cells,TIL cells and regulatory T cells in IA increased,APC co-stimulation score,APC co-inhibition score,CCR score,immune examination point score,HLA score,pro-inflammatory score,para-inflammatory score,T cell co-stimulation score,T cell co-inhibition score and type 2 immune response score increased.Correlation analysis showed that core genes were correlated with immune cell infiltration and immune status scores.Conclusion hsa-miR-3176,hsa-miR-1246 and hsa-miR-539-3P are lowly expressed in IA tissues,and their low expression will lead to the occurrence of intracranial aneurysms.
Objective To study the clinical effect of warming kidney and tonifying qi,reducing urination for preventing enuresis on improving urinary control after benign prostatic hyperplasia.Methods A total of 84 patients with benign prostatic hyperplasia who underwent surgical treatment in our hospital from March 2018 to December 2022 were selected as the research objects.They were divided into control group(41 patients)and observation group(43 patients)by random number table method.The control group was treated with warming kidney and tonifying qi method,and the observation group was treated with warming kidney and tonifying qi,reducing urination for preventing enuresis method.The recovery rate of urinary control,recovery time of urinary control,recovery index of urinary control(residual urine volume of bladder,frequency of urine leakage,urine leakage),occurrence of urinary incontinence,urodynamic index and quality of life were compared between the two groups.Results The recovery rate of urinary control in the observation group was higher than that in the control group,and the recovery time of urinary control was shorter than that in the control group(P＜0.05).The bladder residual urine volume,urine leakage times and urine leakage volume in the observation group were lower than those in the control group(P＜0.05).The incidence of urinary incontinence(grade Ⅰ and grade Ⅱ)in the observation group was lower than that in the control group(P＜0.05).After treatment,the maximum urinary flow rate(Qmax)and maximum urethral closure pressure(MUCP)in the observation group were higher than those in the control group(P＜0.05).The quality of life of the two groups after treatment was higher than that before treatment,and that of the observation group was higher than that of the control group(P＜0.05).Conclusion The method of warming kidney and tonifying qi,reducing urination for preventing enuresis has a good effect on improving urinary control after benign prostatic hyperplasia,which can improve the recovery rate of urinary control,shorten the recovery time of urinary control,reduce the residual urine volume of bladder,the number of urine leakage and the amount of urine leakage,reduce the incidence of urinary incontinence,improve the urodynamic index and the quality of life of patients after operation.
Non-alcoholic fatty liver disease(NAFLD)is one of the most common causes of liver disease worldwide.It is defined as the presence of ≥5％hepatocellular steatosis in patients without a significant history of alcohol consumption and other liver diseases.The prevalence of NAFLD is currently increasing at an alarming rate globally,but its exact pathogenesis is not completely understood.The most compelling clue to the pathogenesis of NAFLD comes from human genetics.Genome-wide studies have shown that different single nucleotide polymorphisms(SNPs)in patatin-like phospholipase domain-containing protein 3(PNPLA3),transmembrane 6 superfamily member 2(TM6SF2),apolipoprotein C3(APOC3),membrane bound O-acyltransferase domain containing 7(MBOAT7)and glucokinase regulatory protein(GCKR)have a considerable impact on NAFLD onset and long-term prognosis.This article reviews the polymorphisms of five genes in the genetic susceptibility of NAFLD in recent years,in order to provide new insights into the pathogenesis of the disease and provide new directions for clinical treatment.
Objective To study the effect of regular nutrition guidance on weight management and pregnancy outcome of perinatal pregnant women.Methods A total of 72 perinatal pregnant women who were examined in our hospital from January 2021 to May 2022 were selected as the research objects.They were divided into study group(n=36)and control group(n=36)by random number table method.The control group was given routine pregnancy guidance,and the study group was given regular nutrition guidance on the basis of the control group.The perinatal nutrition indexes(calcium,iron,zinc),pregnancy outcome(cesarean section,vaginal delivery),incidence of pregnancy complications,incidence of delivery complications,and weight of perinatal pregnant women were compared between the two groups.Results The levels of calcium,iron and zinc in the study group were higher than those in the control group(P＜0.05).The cesarean section rate of the study group was lower than that of the control group,and the vaginal delivery rate was higher than that of the control group(P＜0.05).The incidence of pregnancy complications in the study group was 5.56％,which was lower than 13.89％in the control group(P＜0.05).The incidence of delivery complications in the study group was 8.33％,which was lower than 22.22％in the control group(P＜0.05).The normal rate of body mass index of perinatal pregnant women in the study group was higher than that in the control group,and the rates of low,high and obesity were lower than those in the control group(P＜0.05).Conclusion Regular nutritional guidance can promote the weight management of perinatal pregnant women,increase the intake of trace elements,prevent pregnancy and delivery complications,and improve pregnancy outcomes.
