The antioxidant activity of the dry extract from the complex plant remedy has been studied in model systems in vitro. The complex plant remedy includes the following species of medicinal plants: Serratula centauroides (L.), Bergenia crassifolia (L.) Fritsch, Rosa davurica Pall., inula helenium L., Echinacea purpurea (L.) Moench. It has been established that the plant remedy under study inhibits the oxidation of the biological substrate preventing from the destruction of beta -carotene (IC50=24.3 mu g/ml)and yolk lipoproteids (IC50=65.8 mu g/ml) and having membrane stabilizing effect in peroxide (IC50=0.97 mu g/ml) and osmotic hemolysis (IC50 =0.11 mu g/ml) of erythrocytes. The complex remedy manifests the radical binding activity for 2,2-dipheny1-1- picrylhydrazyl (DPPH') (IC50 =61.4 mu g/ml), superoxide anion-radical (IC50 =28.6 mu g/ml), nitrogen oxide (IC50 =55.3 mu g/ml), also for Fe2+ (IC50 =639.3 mu g/ml). The marked antioxidant activity of the tested remedy is due to the complex of biologically active substances (flavonoids, tannins, polyphenolic compounds, phenol carbonic acids, ecdysteroids, etc.) contained in its components.

During experiments on white rats of the Wistar line, anti-inflammatory activity of the extract of dry complex herbal remedy (Juglans regia L. Rich ex Kimth., Corylus avellana L., Agrimonia eupatoria L., Bidens tripartita L., Xanthium strumarium L., Urtica dioica L. Lemna minor L., Cichorium intybus L., Onopordum acanthium L.) was examined on models of acute exudative (carrageenan and formalin), chronic alterative and proliferative inflammation. It is found that phytoextract in doses of 100-300 mg/kg has antiexudative activity, reducing the exudation caused by phlogogenic agents. The tested extract has an anti-alterative effect, limiting the alteration of tissues with acetic acid and enhancing regenerative processes.

Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body,  significant increase in oxygen consumption followed by activation of  the lipid peroxidation and decrease of endogenic antioxidant system efficacy. The aim of the present study was to evaluate the influence of the complex plant remedy on exercise tolerance of laboratory animals and to reveal mechanisms increasing physical endurance. Materials and methods. The experiments were carried out on white Wistar rats weighing 190-220 g. The physical endurance of the animals was estimated by recording time of weighted swimming to  complete exhaustion in the pool. The weighting was 7 % of the body  mass. The water solution of the dry extract derived from five  medicinal plants was introduced intragastrically to the animals of the experimental group at the dose of 100 mg/kg in the volume of 10  ml/kg for 7 days (once a day), an hour before testing. The content of ATP, lactic acid and pyruvic acid were determined in the skeletal  muscle homogenate; glycogen was determined in the liver  homogenate; in the blood serum there was estimated concentration  of malonic dialdehyde, the activity of catalase; the concentration of  reduced glutathione was determined in the whole blood and the  activity of superoxide dismutase was estimated in erythrocytes. Conclusion. The course introduction of the complex plant remedy to rats results in resilience to intensive physical exertion due to  optimization of energy metabolism, inhibition of free-radical  biomacromolecule oxidation processes and increase in endogenic antioxidant system activity.

Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body, significant increase in oxygen consumption followed by activation of the lipid peroxidation and decrease of endogenic antioxidant system efficacy.The aim of the present study was to evaluate the influence of the complex plant remedy on exercise tolerance of laboratory animals and to reveal mechanisms increasing physical endurance.Materials and methods. The experiments were carried out on white Wistar rats weighing 190-220 g. The physical endurance of the animals was estimated by recording time of weighted swimming to complete exhaustion in the pool. The weighting was 7 % of the body mass. The water solution of the dry extract derived from five medicinal plants was introduced intragastrically to the animals of the experimental group at the dose of 100 mg/kg in the volume of 10 ml/kg for 7 days (once a day), an hour before testing. The content of ATP, lactic acid and pyruvic acid were determined in the skeletal muscle homogenate; glycogen was determined in the liver homogenate; in the blood serum there was estimated concentration of malonic dialdehyde, the activity of catalase; the concentration of reduced glutathione was determined in the whole blood and the activity of superoxide dismutase was estimated in erythrocytes.Conclusion. The course introduction of the complex plant remedy to rats results in resilience to intensive physical exertion due to optimization of energy metabolism, inhibition of free-radical biomacromolecule oxidation processes and increase in endogenic antioxidant system activity.

A polyextract consisting of the extracts of the five title plants shows a marked prostate-protective effect in experimental chronic prostatitis. The pharmacotherapeutic efficacy of the phytoextract gives a basis to recommend its use in complex treatment and prophylaxis of prostatitis.

The present work reviews the evolution of the traditional medicine in Buryatia; the contribution of Oriental medical schools and the Russian experience of herbal treatment were emphasized. This convergence process was developed in virtue of the geopolitical situation of the Republic. The evolution of the tradition and contribution of ethnic medical schools was schematically presented in the article. The aim of the work was to substantiate the originality of the Buryat traditional medicine. The data elucidating the pervasion of Eastern traditions due to the influence of Buddhism and the experience of the Russian settlers are given in the article. Peculiarity of the traditional medicine in this region involves the use of indigenous plants, original formularies and healing technologies. Approach to health and illness, principles of diagnostics and specific methods of treatment remain common to Eastern medical traditions. The article provides insight into the main findings of the study of this tradition. They include such aspects as the translation of written sources, development of new technologies and methods for the treatment and prevention of some diseases, new medicinal preparations and health-improving means recommended for practical use. Besides, there have been discussed the prospects for integration of rational methods and means from the array of the traditional medicine of Buryatia with modern medical and pharmaceutical technologies.

The present work reviews the evolution of the traditional medicine in Buryatia; the contribution of Oriental medical schools and the Russian experience of herbal treatment were emphasized. This convergence process was developed in virtue of the geopolitical situation of the Republic. The evolution of the tradition and contribution of ethnic medical schools was schematically presented in the article. The aim of the work was to substantiate the originality of the Buryat traditional medicine. The data elucidating the pervasion of Eastern traditions due to the influence of Buddhism and the experience of the Russian settlers are given in the article. Peculiarity of the traditional medicine in this region involves the use of indigenous plants, original formularies and healing technologies. Approach to health and illness, principles of diagnostics and specific methods of treatment remain common to Eastern medical traditions. The article provides insight into the main findings of the study of this tradition. They include such aspects as the translation of written sources, development of new technologies and methods for the treatment and prevention of some diseases, new medicinal preparations and health-improving means recommended for practical use. Besides, there have been discussed the prospects for integration of rational methods and means from the array of the traditional medicine of Buryatia with modern medical and pharmaceutical technologies.

В связи с сохраняющимся ростом заболеваний щитовидной железы актуальным является поиск средств растительного происхождения, обладающих тиреотропным действием. В этом аспекте перспективным является разработка комплексного растительного средства на основе экстракта лапчатки белой. Разработано комплексное растительное средство, в состав которого входят сухие экстракты лапчатки белой, шлемника байкальского и родиолы розовой. В настоящей работе проведена оценка влияния комплексного растительного средства «Тиреотон» на течение экспериментального гипотиреоза у белых крыс линии Wistar. В результате проведенного исследования установлено, что «Тиреотон» в дозе 50 мг/кг оказывает выраженное влияние на тиреоидный статус при экспериментальном гипотиреозе, повышая уровень гормонов щитовидной железы крыс тироксина в 2,2 раза, трийодтиронина на 47 % и уменьшая уровень тиреотропного гормона на 50 % по сравнению с данными в контрольной группе животных.

The aim of the research was to define anticonvulsive effect of the dry extract from Paeonia anomala L. and comparison with its liquid dosage form. Convulsions in male SVA rats weighing 18-20 g were induced by single dosing of pentylenetetrazol, strychnine nitrate and thiosemicarbazide in a dose of DL1gg Animals of the trial group had single intragastric introduction of peony extract solution in a dose of 150 mg/kg 1 hour before the introduction of above mentioned medicines. As the result it was found that dry extract of Paeonia anomala L. had evident anticonvulsant effect.

Aim. To assess the effect of dry extract of Gentiana algida in experimental bronchopneumonia of combined etiology. Methods. The experiments were conducted on 32 white Wistar rats (body weight of 180-200 g). The animals were divided in 4 groups, 8 animals each. Bronchopneumonia was caused by dichlorvos inhalations followed by pharyngeal contamination by Staphylococcus aureus (1 bln/ml). Dry extract of Gentiana algida was given intragastrically at a dose of 200 mg/kg once a day for 7 days to the study group rats. Control group rats received distilled water with the same regimen. Comparison group rats received 40 mg of alantonum known as a mucolytic, anti-inflammatory and antibacterial agent. The fourth group consisted of intact animals. The clinical course of the disease was assessed according to the clinical symptoms, peripheral blood count, O2 and CO2 partial blood pressure, lung tissue histological examination and lipid peroxidation processes intensity and antioxidant enzymes activity. Results. Treatment of experimental bronchopneumonia by dry extract of Gentiana algida at a dose of 200 mg/kg was associated with lower mortality, less severe clinical course, lower respiratory rate. Also, a statistically significant erythrocyte sedimentation rate and white blood cells count decrease was noted, indicating the anti-inflammatory effect of the extract. Partial arterial blood pressure of respiratory gases has normalized, indicating the lung ventilation improvement. The effect of dry extract of Gentiana algida according to the noted parameters was superior to alantonum used as a comparison drug. Anti-inflammatory effect of the tested plant extract might be a result of lipid peroxidation inhibition, confirmed by statistically significant decrease of the peroxidation products (malonic dialdehyde and conjugated dienes) and increase of antioxidant protection enzymes (superoxide dismutase and catalase) activity. Conclusion. Dry extract of Gentiana algida at a dose of 200 mg/kg has a positive effect in treatment of acute experimental bronchopneumonia, promoting the respiratory organs morphologic and functional status normalization in laboratory animals at the earlier stages of the disease.

The prevalence of risk factors for heart diseases was studied in 7-17 years-old. children of two ethnic groups living in the Buryat Republic. It has been established that the combination of two and more risk factors increases the danger of arterial hypertension development. Ethnic component has no any significance in the development of heart abnormalities.

Токсическое действие ртути на организм человека обусловлено блокадой кальциевых ка-налов, сульфгидрильных, фосфатных, аминных и карбоксильных групп ферментных и структурных белков. В частности она является ингибитором активности цитохромоксидазы, лактатдегидроге-назы, малатдегидрогеназы и транспортных АТФ-аз [13]. В экспериментальной медицине «сулемовая почка» рассматривается как классический вариант некронефроза [7].

Вопросы сохранения и укрепления здоровья населения становятся актуальными в условиях современного общества с присущими ему особенностями. Это связано со снижением адаптационных возможностей человека под влиянием экстремальных факторов в условиях интенсивного изменения среды обитания. Многокомпонентное фитосредство тибетской медицины «Арура-Тан № 7» является эффективным иммунокорригирующим средством, что позволяет рекомендовать его в ка-честве биологически активной добавки к пище для использования в комплексной терапии различных заболеваний, связанных с нарушениями иммунной системы организма. = The problem of preservation and promotion of public health is actial in today's society with its inher-ent characteristics. It is associated with a reduced adaptability person under the influence of extreme fac-tors in intensive habitat change. Multicomponent collection of medicinal plants – «Arouri –Tan № 7» is an effective immunocorrective tool that allows to recommend it to the quality of biologically active food additives for use in the treatment of various diseases associated with disorders of the immune system.

The article presents data on the influence of the Poligonum aviculare L. dry extract on the functional state of kidneys of white rats at the nephropathy by bichloride of mercury. It was determined that the extract had. nephroprotective and antioxidative activity.

Course introduction of a cowberry dry extract Comarum palustre L. on a background of experimental chronic glomerulonephritis renders expressed nephroprotective influence described by normalization of parameters of a kidneys functional condition, blood lipid spectrum and immune status, reduction of expressiveness of destructive changes in nephrones, inhibition of free-radical processes and increase of organism antioxidative protection.

Большинство патологических процессов сопровождается дисбалансом окислительно-восстановительных систем организма, что приво-дит к повышению уровня свободных радикалов в клетках. В этой связи поиск эффективных антиокси-дантов, воздействующих на различные стадии окис-лительных процессов является одной из актуальных проблем медицины [1, 8]. Исследования последних лет показали, что природные соединения могут воз-действовать на различные системы организма, в том числе на систему антиоксидантной защиты [3, 13].В Институте общей и экспериментальной био-логии СО РАН разработано комплексное раститель-ное средство «Нефрофит», представляющий собой сухой экстракт, состоящий из экстрактов трех видов растительного сырья: листьев толокнянки обыкно-венной (