Castration-resistant prostate cancer (CRPC) is an intractable disease, but approaches for eradicating primary tumors and inhibiting metastasis are limited. Considering that lipid metabolism plays key roles in ferroptosis and tumor progression and treatment resistance, here we developed a biomimetic nanovesicle (FiFe@RBM) encapsulating fatty acid synthetase inhibitors and iron oxide nanoparticles for synergistic therapy of CRPC and inhibiting the metastasis. FiFe@RBM with superior magnetic properties efficiently delivered drugs into the CRPC cancer cells, where it can release Fe ions to efficiently induce reactive oxygen species and mitochondrial dysfunction and inhibit the AKT-mTOR pathway, which synergistically causes apoptosis and enhances ferroptosis by rewired lipid metabolism through increasing polyunsaturated fatty acids (PUFAs), PUFA-enriched phosphatidylcholine (PUFA-PC), PUFA-enriched phosphatidylethanolamine (PUFA-PE), etc. By intravenous injection, the high accumulation of FiFe@RBM in PC-3 tumors enabled precision T1/T2-weighted magnetic resonance imaging-guided effective eradication of human CRPC PC-3 tumors by synergistic magnetic hyperthermia therapy (MHT) and ferroptosis, which further inhibited liver metastasis by the activated and recruited high rates of natural killer cells in the nude mice model. This work presents an effective nanovesicle strategy for reprogramming lipid metabolism to enhance ferroptosis in synergy with MHT for effectively treating refractory cancers.

Objectives To develop and validate a predictive model based on clinical features and multiparametric magnetic resonance imaging (mpMRI) to reduce unnecessary systematic biopsies (SBs) in biopsy-naïve patients with suspected prostate cancer (PCa). Methods A total of 274 patients who underwent combined cognitive MRI-targeted biopsy (MRTB) with SB were retrospectively enrolled and temporally split into development ( n = 201) and validation ( n = 73) cohorts. Multivariable logistic regression analyses were used to determine independent predictors of clinically significant PCa (csPCa) on cognitive MRTB, and the clinical, MRI, and combined models were established respectively. Area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analyses were assessed. Results Prostate imaging data and reporting system (PI-RADS) score, index lesion (IL) on the peripheral zone, age, and prostate-specific antigen density (PSAD) were independent predictors and included in the combined model. The combined model achieved the best discrimination (AUC 0.88) as compared to both the MRI model incorporated by PI-RADS score, IL level, and zone (AUC 0.86) and the clinical model incorporated by age and PSAD (AUC 0.70). The combined model also showed good calibration and enabled great net benefit. Applying the combined model as a reference for performing MRTB alone with a cutoff of 60% would reduce 43.8% of additional SB, while missing 2.9% csPCa. Conclusions The combined model based on clinical and mpMRI findings improved csPCa prediction and might be useful in making a decision about which patient could safely avoid unnecessary SB in addition to MRTB in biopsy-naïve patients. Critical relevance statement The combined model based on clinical and mpMRI findings improved csPCa prediction and might be useful in making a decision about which patient could safely avoid unnecessary SB in addition to MRTB in biopsy-naïve patients. Key points • Age, PSAD, PI-RADS score, and peripheral index lesion were independent predictors of csPCa. • Risk models were used to predict the probability of detecting csPCa on cognitive MRTB. • The combined model might reduce 43.8% of unnecessary SBs, while missing 2.9% csPCa. Graphical Abstract

Background: Capsule-preserving hydrodilatation is a common treatment for adhesive capsulitis (AC), and ultrasound (US) has recently become the most popular adjuvant tool for image-guided glenohumeral joint injection. However, traditional US is hardly adequate to assess extracapsular fluid leakage, which may decide the treatment outcomes. In this study, we explored the value of contrast-enhanced ultrasound (CEUS) guided capsule-preserving hydrodilatation with steroids and ultrasonic contrast agents for treatment of AC. Methods: A total of 40 consecutive patients with AC were prospectively enrolled and received CEUS-guided capsule-preserving hydrodilatation. The number of injection attempts, injection volume, and fluid leakage were recorded, and the correlations with clinical features were analyzed by Pearson or Spearman correlation coefficients. Outcome measures including visual analog scale (VAS) score, passive range of motion (ROM), and shoulder pain and disability index (SPADI) score were evaluated at baseline and 4 weeks after treatment. Comparisons between patients with good and poor clinical outcomes were performed with independent t-test, Mann-Whitney U test, and chi-square test. Logistic regression was used to identify predictors of good clinical outcomes. A P value <0.05 defined significance. Results: Access to the glenohumeral joint was successful in 87.5% patients on the first attempt. The infused fluid volume was 21.0 +/- 3.40 mL. Longer symptom duration (r=-0.676, P<0.001), greater SPADI (r=-0.148, P=0.007), and decreased ROM in abduction (r=0.38, P=0.016) were associated with a decreased volume of infused fluid. CEUS detected massive fluid leakage in 5 (12.5%) patients, with 4 capsule ruptures confirmed by magnetic resonance imaging (MRI). Longer symptom duration (r=0.485, P=0.001), decreased ROM in the direction of abduction (r=-0.33, P=0.037), and external rotation (r=-0.34, P=0.032) were correlated with an increased incidence of massive fluid leakage. Moreover, patients with good outcomes had significantly shorter symptom duration (5.7 +/- 2.09 vs . 11.2 +/- 3.89 months, P=0.002) and greater initial VAS score (6.9 +/- 1.04 vs . 6.3 +/- 0.50, P=0.022) than those with poor outcomes. Absence of massive fluid leakage was an independent predictor of clinical good outcomes at 4 weeks after treatment [odd ratio (OR) =0.05, 95% confidential interval (CI): 0.003-0.882, P=0.041]. Conclusions: CEUS-guided capsule-preserving hydrodilatation allows real-time visualization of capsule dilatation, accurate detection of extracapsular fluid leakage, and identification of risks for capsule rupture. It provides an effective treatment for AC, and is useful to predict patients' clinical outcomes.

Microwave thermotherapy (MT) is a clinical local tumor ablation modality, but its applications are limited by its therapeutic efficacy and safety. Therefore, developing sensitizers to optimize the outcomes of MT is in demand in clinical practice. Herein, we engineered a special nanoframework (i.e., FdMI) based on a fucoidan-decorated zirconium metal-organic framework incorporating manganese ions and liquid physisorption for microwave tumor ablation. The monodisperse nanoframework exhibited both microwave thermal effects and microwave dynamic effects, which could effectively kill cancer cells by efficient intracellular drug delivery. Through fucoidan-mediated targeting of P-selectin in the tumor microenvironment (TME), the FdMI effectively accumulated in tumor regions, leading to significant eradication of orthotropic triple-negative breast cancer (TNBC) and aggressive Hepa1-6 liver tumors by the synergistic effects of microwave thermotherapy/dynamic therapy (MT/MDT). The eradication of primary tumors could activate systemic immune responses, which effectively inhibited distant TNBC tumors and lung metastasis of Hepa1-6 liver tumors, respectively. This work not only engineered nanoparticle sensitizers for tumor-targeted synergistic MT/MDT but also demonstrated that nanocarrier-based microwave tumor ablation could stimulate antitumor immunity to effectively inhibit distant and metastatic tumors, demonstrating the high potential for effectively managing advanced malignant tumors.

烟草是我国的一种重要经济作物，可以给种植户带来经济效益，帮助改变农户生活水平。因此关注烟草种植优质高效栽培技术，提升烟草种植产量、质量，可以进一步帮助种植户增收。该文首先对烟草种植所需的地理环境条件进行了分析介绍，其次分析了烟草优质高效栽培技术的应用原则，最后介绍了烟草优质高效栽培技术应用要点。希望通过分析介绍，给相关人员提供一定的帮助，推动烟草行业的健康可持续发展。

Although esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers, there are major bottlenecks in its therapeutic approaches, primarily the identification of clinically relevant targets and the lack of effective targeted therapeutics. Herein, we identified the hallmarks of ESCC, namely, high T-lymphokine-activated killer cell-originated protein kinase (TOPK) expression in human ESCC tumors and its correlation with poor patient prognosis and hypoxia in the tumor microenvironment. We developed hypoxia-sensitive nanoparticles encapsulating TOPK inhibitor OTS964 and photosensitizer chlorin e6 for the imaging-directed precision therapy of ESCC tumors. The sub-100 nm monodisperse nanoparticles efficiently delivered drugs into the human ESCC KYSE 150 cancer cells to kill the cells. The nanoparticles were selectively accumulated in the ESCC tumors after intravenous (i.v.) injection, thereby enabling the diagnosis and photoacoustic imaging-guided local laser irradiation of tumors. The combination of chemotherapy and photodynamic therapy effectively eradicated human ESCC KYSE 150 tumors and inhibited liver metastasis and recurrence by suppressing TOPK and inducing ESCC cell apoptosis. The nanoparticle-based therapies further stimulated high rates of natural killer cells in ESCC tumors, thereby exhibiting the potential of immunotherapy. This study identified important therapeutic targets of ESCC tumors and delineated an effective nanocarrier-based approach for tumor microenvironment and molecular targeted therapy.

BackgroundMRI‐targeted biopsy (MRTB) improves the clinically significant prostate cancer (csPCa) detection rate with fewer biopsy cores in men with suspected PCa. However, whether concurrent systematic biopsy (SB) can be avoided in patients undergoing MRTB remains unclear.PurposeTo evaluate the potential value of MRI‐based radiomics models in avoiding unnecessary SB in biopsy‐naïve patients.Study typeRetrospective.PopulationA total of 226 patients (mean age 66.6 ± 9.02 years) with suspicion of PCa (PI‐RADS score ≥ 3) and received combined cognitive MRTB with SB were retrospectively recruited and randomly divided into training (N = 180) and test (N = 46) cohorts at an 8:2 ratio.Field Strength/SequenceA 3.0 T, biparametric MRI (bpMRI) including T2‐weighted imaging (T2WI) and apparent diffusion coefficient (ADC) map.AssessmentThe whole prostate gland (PG) and the index lesion (IL) were delineated. Three radiomics models of bpMRIPG, bpMRIIL, and bpMRIPG+IL were constructed, respectively, and the performance of each radiomics model was compared with that of PI‐RADS assessment.Statistical TestsThe least absolute shrinkage and selection operator (LASSO) regression method was used to select texture features. The area under the curve (AUC) and decision curve analysis were used to estimate the models.ResultsThe bpMRIPG+IL radiomics model exhibited good discrimination, calibration, and net benefits, which would reduce the SB biopsy in 71.2% and 71.4% of men with PI‐RADS ≥ 5 lesions in the training and test cohorts, respectively.Data ConclusionA bpMRIPG+IL radiomics model may outperform PI‐RADS category in help reducing unnecessary SB in biopsy‐naïve patients.Evidence Level3Technical EfficacyStage 6

尽管多参数磁共振成像(multiparametric magnetic resonance imaging,mpMRI)在前列腺癌(prostate cancer,PCa)的诊断、分期、疗效评价及随访中发挥了重要作用,但仍存在假阳性率较高、观察者间一致性较差等不足.影像组学可从医学影像图像中挖掘高通量的定量影像特征,提高疾病诊断和预测效能.目前,前列腺MRI影像组学已广泛用于PCa的诊断与鉴别诊断、PCa侵袭性评估及预测生化复发等方面.本文就MR I影像组学在前列腺癌诊断及预后评估中的应用进展进行综述.

不同烤烟品种烤后烟叶具有不同的外观及内在质量表现,而外观质量检验是开展烟叶分级、收购、工商交接业务的重要手段.了解并掌握不同品种的识别方法,对提高烟叶分级收购水平、密切工商协作关系具有重要意义.通过对临沂产区近年种植的主栽品种外观质量特征开展研究,筛选与遗传因素密切相关的烟叶主要外观特征作评价指标,剔除各品种外观特征相同或相似部分,找出各品种的主要识别特征,并通过这些特征逆向判断分析,形成了各品种的主要评价指标及识别方法,建立了临沂主栽品种烟叶样品库和外观质量影像资料数据库.研究为分级人员快速识别品种、精准评级和进一步开展品种研究提供了方法借鉴和有效技术支撑.

Background Ultrasound (US) guided transoral biopsy is a novel and safe procedure for obtaining tissue in patients with oral masses. However, this procedure is less commonly used in comparison to US guided transcutaneous biopsy. The aim of this study is to compare the efficacy and safety of US-guided transoral and transcutaneous core needle biopsy (CNB) in patients with oral masses. Methods From November 2019 to March 2021, consecutive patients with oral masses were randomly assigned to undergo US-guided transoral CNB (transoral group) and US-guided transcutaneous CNB from a submental approach (transcutaneous group). During the operation, procedure time, intra‑operative blood loss volume, diagnostic performance, rate of complications and pain level were recorded and compared. Results There were 112 patients (62 in the transoral group and 50 in the transcutaneous group) evaluated in this study. The postprocedural complication rate of the transcutaneous group was significantly higher than the transoral group (24% vs. 0%, P = 0.000). There was no significant difference in accuracy (95.2% vs. 88%, P = 0.30), biopsy time (76 ± 12 s vs. 80 ± 13 s, p = 0.09), blood losses (2.6 ± 0.5 mL vs. 2.7 ± 0.4 mL, p = 0.17) and visual analogue score ( p = 0.327 and p = 0.444 before and after the sampling procedure) between the two groups. Conclusion US-guided transoral CNB results in high rates of technical success and lower rates of postprocedural complications.

[目的]明确山东烤烟外观质量特征及其用途.[方法]选取2020年山东临沂、日照、潍坊3个地级市15个主烟区的155份烤烟作为典型代表性样品,其中包含C2F、C3F、B2F、X2L、X3L、X2F、X3F、C2L、C3L、B3F、B2L、B3L,分别统计分析外观质量特征、常规化学成分和感官质量指标.[结果]下部烟叶外观质量特征:颜色在柠檬黄至桔黄区间,烟叶成熟,叶片结构总体表现为疏松,油分稍有,身份稍薄,色度中;中部烟叶外观质量特征:颜色在柠檬黄至桔黄区间,烟叶成熟,结构疏松,油分有,身份中等,色度总体表现为"强";上部烟叶外观质量特征:颜色在柠檬黄至桔黄区间,烟叶成熟,结构尚疏松至稍密,油分有,身份稍厚,色度总体表现为"强".叶片结构越紧密,还原糖含量、钾氯比、糖碱比、氮碱比、总糖、钾、施木克值相对越低,总植物碱、总氮、氯、蛋白质、两糖差相对越高.烟叶油分越多,总植物碱、总氮含量相对越高,钾氯比、钾含量、糖碱比、氮碱比相对越低.叶片结构越疏松,感官质量中评吸总分越高,香气质、燃烧性越好,蜜甜香、甜度越明显,杂气、刺激性越少,余味越舒适,木香、焦香、浓度、劲头变化越明显.烤烟颜色越接近桔黄、柠檬黄色,成熟度越好,身份越中等,油分越多,色度越浓,则感官质量中评吸总分越高,典型度、蜜甜香、焦香、甜度越明显,浓度、劲头越中等,香气质、透发性越好,香气量越多,杂气、刺激性越少,余味越舒适.[结论]烟叶的外观质量特征可反向判断烟叶产地;叶片结构、油分可作为影响或反映蜜甜焦香型主产区烤烟独特风格及质量的关键外观质量的特征指标.

为解决焦炉煤气制LNG、甲醇等项目中预加氢、一级加氢、二级加氢样品中硫化物检测组分浓度差异大使得部分硫化物需要稀释进样的问题,采用价格低、普及性高的火焰光度检测器及填充柱气相色谱仪,通过减小定量环、改造信号放大组件、分段拟合等手段将直接进样检测焦炉煤气中形态硫的质量浓度检测范围拓宽至2.86～142.86 mg/m3.结果表明,在上述范围内一定浓度梯度进行复测,所得数据线性相关性高,满足相关标准要求.同时,该方法还能避免因焦炉煤气中各形态硫组分浓度差异大所造成的稀释后部分硫化物浓度过低而无法被检出的问题.

PurposeTo determine whether additional systematic biopsy is necessary in all biopsy naïve patients with MRI visible lesions by taking PI-RADS score and prostate volume into consideration.Materials and MethodsPatients who underwent combined systematic biopsy (SB) and cognitive MRI-targeted biopsy (TB) in our hospital between May 2018 and June 2020 were retrospectively reviewed. The detection rate of clinical significant prostate cancer (csPCa), biopsy grade group (GG) concordance, and disease upgrading rate on radical prostatectomy were compared between SB and TB and further stratified by PI-RADS v2.0 category and prostate volume.ResultsA total of 234 patients were analyzed in this study. TB alone detected more csPCa and less clinically insignificant prostate cancer (cisPCa) than SB alone in the whole cohort (57.3 vs 53%, P = 0.041; 3.8 vs 7.7%, P = 0.049 respectively). The additional SB indicated only a marginal increase of csPCa detection but a remarkable increase of cisPCa detection compared with targeted biopsy (59.4 vs 57.3%, P = 0.064; 3.8 vs 7.7%, P = 0.012). As stratified by PI-RADS category, the difference of csPCa detection rate between TB and SB was not significant either in PI-RADS 5 subgroup (83.8 vs 76.3%, P = 0.07) or in PI-RADS 3–4 subgroup (43.5 vs 40.9%, P = 1.0). Additional SB decreased the rate of disease upgrading on radical prostatectomy (RP) than TB alone in PI-RADS 3–4 subgroup (14.5 vs 25.5%, P = 0.031) other than PI-RADS 5 subgroup (6 vs 6%, P = 1.0). When stratified by prostate volume (PV), TB alone detected more csPCa than SB in small prostate (PV < 30 ml) group (81.0 vs 71.0%, P = 0.021) but not in large prostate (PV ≥ 30 ml) group (44.0 vs 42.7%, P = 0.754). The additional SB did not significantly decrease the rate of disease upgrading on RP than TB alone in either small or large prostate (6.4 vs 8.5%, P = 1.0; 13.8 vs 22.4%, P = 0.063).ConclusionThe combination biopsy method was no superior than targeted biopsy alone in PI-RADS 5 or in small volume prostate subgroup.

目的 探讨超声剪切波弹性成像在前列腺癌诊断中的价值.方法 选取门诊及住院怀疑前列腺癌的134例患者行经腔内超声引导下前列腺穿刺活检,穿刺前均行经腔内二维超声及剪切波弹性成像检查,以病理结果为金标准,构建剪切波弹性成像鉴别前列腺良恶性病灶的受试者工作特征(ROC)曲线,并使用秩相关分析前列腺病灶弹性杨氏模量值与其病理结果Gleason评分的相关性.结果 前列腺癌109例,前列腺良性病灶25例;以Emean 79.8 kPa为最佳临界值,其曲线下面积为0.76(P<0.001),敏感度及特异度分别为83.5％、50.0％.前列腺癌病灶平均杨氏模量值(Emean)与其病理Gleason评分呈正相关(r=0.345,P<0.05).结论 超声剪切波弹性成像对前列腺良恶性疾病鉴别有一定的优势.

目的 探讨甲状腺转移癌(TM)的临床特点、超声特征和其诊断价值.方法 回顾分析16例经术后病理证实的TM患者的超声声像图特征和临床资料.结果 16例患者的原发病灶依次为食管癌5例(31.2％),乳腺癌3例(18.7％),肺癌3例(18.7％),肾癌2例(12.5％),黑色素瘤2例(12.5％),前列腺癌1例(6.2％).TM超声表现分别为结节型(81.3％)和弥漫浸润型(18.7％).结节型TM超声声像图特征:76.5％(13/17)形态不规则;64.7％(11/17)边界不清;70.6％(12/17)实性低回声;41.2％(7/17)侵犯甲状腺包膜,呈浸润性生长;52.9％(9/17)钙化;70.5％(12/17)血流信号丰富.弥漫型TM甲状腺实质呈弥漫性不均匀低回声,没有明确边界,血流信号丰富.37.5％(6例)患者伴颈部淋巴结转移.结论 TM的超声声像图具有一定的特征性,结合其临床资料有助于提高诊断准确率.

Background: Desmoplastic small round cell tumor (DSRCT) mostly arose in the abdominopelvic cavity is an aggressive sarcoma with poor prognosis. The purpose of this study is to analyze ultrasonographic performance in prediction of prognosis of DSRCT. Method: Between March 1999 and October 2019, a total of 27 patients with pathologically confirmed DSRCT in our hospital were conducted. Clinical and ultrasonographic characterizations, including age, sex, symptoms, tumor size, number, location, shape, margin, echogenicity, homogeneity, vascularity, and metastases were recorded and analyzed with overall survival (OS) by using univariate analysis. Result: Ultrasonographic performance of DSRCT were irregular (74%), posterior echo enhancement (63%), calcification (51.9%), and liquefaction (55.6%) in tumors companied with ascites (63%), hydronephrosis (59%) and metastases (63%). The median OS was 22 months (range 7–36 months) and 5-year OS rate was 19.6%. Using univariate analysis, a higher hazard ratio (HR) of mortality was associated with liquefaction (HR: 3.09, 95% CI:1.23-7.76, p =0.016) and bone metastasis (HR: 2.95, 95%CI: 1.16-7.49, p =0.023). According to a risk staging system developed by selected predictors (low = neither liquefaction nor bone involvement; moderate = either liquefaction or bone involvement; high = both liquefaction and bone involvement), 40%, 10%, and 0 of 3-year survival were found in the low, moderate, and high risk patients, respectively. Conclusion: Ultrasound imaging is effective to evaluate prognosis of DSRCT. Findings of liquefaction and bone involvement in the ultrasonography may predict a poor prognosis of DSRCT patients.

以吸收光谱为基础的高精度光学腔气体检测技术用于大气中痕量NO2气体的分析具有在线、实时、高灵敏度等优点.分析了近年来NOx排放情况和主要排放源,并针对采用其他光学仪器测量NO2时存在稳定性不好、受标样影响等问题,搭建了一套适合在线分析NO2的测量装置;通过仿真选择了1630.33 cm-1光谱吸收段用于NO2的测量,利用Allan方差分析评估了系统的稳定性.结果 表明,在积分时间为200 s时,对应的最低检测限为3.1×10-9(体积分数).将该装置应用于西部某煤化工企业的燃煤烟道气中NO2浓度的检测和分析,其结果与实际情况高度吻合.

The purpose of this study was to determine the efficacy and safety of contrast-enhanced ultrasound (CEUS)–guided celiac plexus neurolysis (CPN) in patients with upper abdominal cancer pain. Thirty-five patients with upper abdominal cancers tortured by intractable upper abdominal pain underwent CEUS-guided CPN with ethanol. The pain alleviation and opioid intake were observed and evaluated during a 3-month follow-up after CPN. The dispersion of alcohol around the aorta was evaluated on 3D-CEUS. Complications were assessed during CPN and at follow-up. All of the 35 patients’ CPN was successfully achieved. Pain relief was observed in 28 (80%), 20 (57.1%), 27 (77.1%), 20 (57.1%), and 10 (29.4%) patients immediately, 1 day, 1 month, 2 months, and 3 months after CPN, respectively. The agent dispersion around the aorta on CEUS images of 28 patients who showed pain relief was at least 90° of the circumference around the aorta. The median duration of pain alleviation was 2.7 months (95% confidence interval [CI], 2.5–2.9). Less than half of the patients had minor complications including irritant pain at the puncture site (8 of 35; 22.9%), diarrhea (4 of 35; 11.4%), nausea and vomiting (3 of 35; 8.6%), and post-procedural hypotension (1 of 35; 2.9%). CEUS-guided CPN is a safe and effective method to alleviate refractory upper abdominal pain in patients with upper abdominal cancers. CEUS image allows the visualization of puncture path and observation of drug dispersion. The pain relief is relevant to the dispersion of neurolytic agent around the aorta. • CEUS-guided celiac plexus neurolysis (CPN) is feasible and easy. • It allows direct visualization of the diffusion of the neurolytic agent in the retroperitoneal anatomic space. • CEUS-guided CPN improves safety of CPN by clearly delineating the needle path.

水冲井窖器是推广水造法井窖移栽方式的关键,项目通过对手持式水冲井窖器在不同土壤类型条件下使用效果的对比研究,探讨形成一套成本低、功能多、适合于多种土壤类型的井窖器推广应用方案,为水造法井窖移栽方式的推广奠定基础.

Stem cells have been used to promote the repair of rotator cuff injury, but their fate after transplantation is not clear. Therefore, contrast agents with good biocompatibility for labeling cell and a reliable technique to track cell are necessary. Here, we developed a micron-sized PLGA/IO MPs to label tendon stem cells (TSCs) and demonstrated that PLGA/IO MPs were safe and efficient for long-term tracking of TSCs by using dual-modal MR and Photoacoustic (PA) imaging both in vitro and in rat rotator cuff injury. Moreover, TSCs improved the repair of injury and the therapeutic effect was not affected by PLGA/IO MPs labeling. We concluded that PLGA/IO particle was a promising dual-modal MR/PA contrast for noninvasive long-term stem cell tracking.