To report a case of staged surgical excision of giant porokeratosis.A 54-year-old man had been seeking medical attention for 29 years due to an itchy purplish-red spot on the right upper abdomen.Dermatological examination revealed a well-defined round purplish-red patch,ap-proximately 15 cm x 15 cm,with rough keratinization and few attached scales on the surface.Brown color was observed around the lesion without any noticeable elevation,erosion or exudation.Histopathological analysis showed hyperkeratosis and parakeratosis,loss of granular layers,irregu-lar thickening of the stratum spinosum,superficial dermal vasodilation and perivascular infiltration of mononucleated cells along with melanophages.Dermoscopy revealed dark red background with clear boundaries,whitish peripheral rim and linear vessels,focal hypopigmentation,comma-like vessels at center,as well as thickened yellow scales in the surrounding area.Diagnosis was poro-keratosis of Mibelli.The skin lesion was surgically removed using a staged excision method over four stages,resulting in successful healing without recurrence during one-year follow-up.

目的 探讨三酰甘油-葡萄糖指数(TyG)及单核细胞与淋巴细胞比值即血液单核细胞与淋巴细胞的比值(MLR)与银屑病冠心病共病的相关性.方法 收集银屑病单病者 61 例,银屑病冠心病共病者 64 例的血常规、血脂、空腹血糖等资料,比较 2 组一般临床资料及MLR、TyG等指标.用Spearman相关性分析探讨银屑病冠心病共病与临床特征及MLR、TyG等指标的关系.Logistic回归分析探讨银屑病冠心病共病的相关危险因素,用受试者工作特征(ROC)曲线探讨不同变量对银屑病冠心病共病的诊断效能.结果 银屑病冠心病共病组MLR、TyG均高于银屑病组(P<0.05).Spearman相关性分析显示银屑病冠心病共病与MLR、TyG呈正向相关关系(P<0.05),Logistic回归分析显示性别(男性)、年龄、高血压病、MLR、TYG均为银屑病冠心病共病的显著危险因素.ROC曲线显示TYG为 0.90时诊断银屑病冠心病共病效能最高,此时的敏感度为 78.1%,特异度为 50.8%.MLR为 0.18 时诊断银屑病冠心病共病效能最高,此时的敏感度为 100%,特异度为 27.87%.结论 银屑病冠心病共病组MLR、TYG较银屑病单病组明显升高,两者均为银屑病冠心病共病的危险因素,均有较好的诊断效能.

Objective:To investigate efficacy and advantages of combined local flaps in repairing large defects in patients with nasal and perinasal non-melanoma skin cancers after Mohs micrographic surgery.Methods:From March 2018 to November 2020, 11 patients with nasal and perinasal non-melanoma skin cancers, who underwent Mohs micrographic surgery followed by repair with combined local flaps, were collected from Department of Dermatology, the Second Hospital of Hebei Medical University. According to the location and size of postoperative defects, flaps were designed based on the nasal aesthetic subunit principle. For large defects that could not be directly sutured or covered by a single local flap, 2 or 3 kinds of flaps were applied in combination, such as kite flap, modified diamond flap, nasolabial skin flap, bilobed skin flap, etc.Results:Among the 11 patients, 10 were diagnosed with basal cell carcinoma and 1 with squamous cell carcinoma, and the area of defects ranged from 2.0 cm × 2.3 cm to 2.7 cm × 3.6 cm. After Mohs micrographic surgery combined with local skin flap repair, all skin flaps survived well without blood supply obstruction, the texture, color and contour of the skin flaps were similar to those of the surrounding normal skin, and no obvious scars were formed. During the postoperative follow-up of 4 to 32 months, no recurrence of the tumors occurred, and the patients was satisfied with the appearance.Conclusion:To repair large defects using combined skin flaps of 2 or 3 kinds after Mohs micrographic surgery in patients with nasal and perinasal non-melanoma skin cancers can maintain the normal nasal or perinasal morphological structure and aesthetic appearance, and yield a satisfactory cosmetic effect.

Lamotrigine is a new type of drug for the treatment of epilepsy, bipolar affective disorder and neuralgia. Drug eruptions are the common adverse reaction to lamotrigine, such as fixed drug eruption, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome, etc. The pathogenesis of lamotrigine-induced drug eruptions includes immune and non-immune mechanisms. HLA alleles are related to drug eruptions caused by lamotrigine, and their relationship varies with the race of populations and type of drug eruptions. This review summarizes the etiology, pathogenesis and clinical characteristics of drug eruptions caused by lamotrigine, aiming to guide clinical treatment.

目的 观察甘草泻心汤加味辅助治疗寒热错杂型复发性口腔溃疡的效果,探讨其治疗作用机制.方法 选择2018年7月—2019年7月在河北省沧州中西医结合医院治疗的240例复发性口腔溃疡患者,随机分为2组各120例,对照组给予常规西医综合治疗,观察组在此基础上联合甘草泻心汤加味治疗,连续治疗14 d.评估2组短期治疗效果,观察2组中医症状积分、唾液表皮生长因子(EGF)水平及血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)]变化情况,随访2组复发情况.结果 观察组总有效率为94.2％(113/120),高于对照组的78.3％(94/120),差异有统计学意义(P<0.05).2组治疗后中医症状积分、唾液EGF水平及血清TNF-α、IL-6、IL-8、IL-10水平均明显降低(P均<0.05),且观察组治疗后的中医症状积分及各项检测指标水平均明显低于对照组(P均<0.05).观察组随访3,6,9,12个月的病情复发率均明显低于同期对照组(P均<0.05).结论 甘草泻心汤加味辅助治疗寒热错杂型复发性口腔溃疡患者效果优于单纯西医治疗,有助于改善中医症状,促进损伤黏膜修复,预防病情复发,可能与减轻炎性反应有关.

目的 建立免疫抑制BALB/c小鼠侵袭性白念珠菌感染的动物模型.为研发新型靶向抗真菌药物提供依据.方法 对BALB/c小鼠腹腔注射环磷酰胺200 mg/kg,每日1次,连续2次,第4天经鼻腔灌注白念珠菌菌悬液50μl(107 cfu/ml),第7天取肺组织标本进行真菌直接镜检、培养、病理检查、(1,3)-β-D-葡聚糖检测及电镜观察.结果 小鼠被注射环磷酰胺的第4天,白细胞2.48×109/L、中性粒细胞16.8×109/L降至最低值.免疫抑制的小鼠经鼻腔灌注白念珠菌菌悬液后的第7天,取肺组织标本进行真菌镜检,镜下可见大量菌丝及芽生孢子,沙堡培养有白念珠菌生长,组织病理可见大量菌丝及芽生孢子及炎性细胞浸润、坏死,(1,3)-β-D-葡聚糖检测(5181.33±223.67) pg/ml与生理盐水对照组(75.62±18.34) pg/ml比较,差异有统计学意义(t=-4.536,P＜0.01),透射电镜可见白念珠菌细胞壁为多层板状结构、清晰的细胞膜及细胞器.结论 对免疫抑制BALB/c小鼠鼻腔灌注白念珠菌菌悬液后,经取肺组织标本进行真菌检查、培养、病理检查、(1,3)-β-D-葡聚糖检测及电镜观察方法,成功建立了免疫抑制BALB/c小鼠侵袭性白念珠菌感染动物模型,为观察药物在体内对真菌细胞壁及(1,3)-β-D-葡聚糖的影响提供了依据.

目的:探讨甘草泻心汤治疗寒热错杂型复发性口腔溃疡的临床疗效及对患者症状体征的影响.方法:以240例复发性口腔溃疡患者为研究对象,按随机数字表法分为对照组(120例,给予常规西药治疗)和研究组(120例,给予甘草泻心汤联合常规西药治疗).统计两组治疗后溃疡疼痛缓解时间、溃疡愈合时间、疼痛程度及临床疗效,并观察两组治疗前后中医证候积分、唾液表皮生长因子(EGF)、血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、白介素-10(IL-10)水平及免疫功能[自然杀伤T细胞(NKT)及T细胞亚群CD3+、CD4+、CD8+]的变化.结果:治疗后,研究组临床疗效高于对照组(98.33％与89.17％),组间比较差异有统计学意义(P<0.05).两组溃疡色淡红、隐痛、反复发作、口苦口渴、胃脘堵闷、食则腹胀、乏力积分均较治疗前降低,研究组均低于对照组,组间比较差异有统计学意义(P<0.05).研究组溃疡疼痛缓解时间、溃疡愈合时间、疼痛程度均低于对照组,组间比较差异有统计学意义(P<0.05).两组EGF、TNF-α、IL-6、IL-8、IL-10均较治疗前降低,且研究组均低于对照组,组间比较差异有统计学意义(P<0.05).两组NKT、CD3+、CD4+、CD8+均较治疗前升高,且研究组NKT、CD3+、CD4+、CD8+均高于对照组,组间比较差异有统计学意义(P<0.05).结论:甘草泻心汤可有效改善复发性口腔溃疡患者临床症状,效果显著,能够缩短溃疡疼痛缓解时间及溃疡愈合时间,降低疼痛程度,减轻炎症反应,调节免疫功能.

目的 探讨雌激素结合康复新液对复发性口腔溃疡小鼠组织损伤的作用及相关机制.方法 C57野生型雄性小鼠48只按照随机数字表法分为3组:模型组、雌激素组与联合组,每组各16只.所有小鼠都建立了复发性口腔溃疡模型,建模后2周,雌激素组给予雌激素注射(250μg/kg)干预,联合组给予雌激素注射(250μg/kg)结合康复新液灌胃(0.2 mL/次)干预,模型组给予同剂量的0.9％氯化钠溶液注射治疗,治疗周期均为2周.治疗第1周与第2周记录各组小鼠体重,检测血清白细胞介素(IL)-6与IL-8表达水平,并于治疗第2周检查口腔溃疡指数和口腔上皮组织Caspase-3蛋白相对表达水平.结果 治疗第1周与第2周,雌激素组与联合组小鼠的体重高于模型组,血清IL-6与IL-8表达水平低于模型组,差异均有统计学意义(P<0.05),且联合组小鼠的体重高于雌激素组,血清IL-6与IL-8表达水平低于雌激素组,差异均有统计学意义(P<0.05).治疗第2周,雌激素组与联合组小鼠的口腔溃疡指数、口腔上皮组织Caspase-3蛋白相对表达水平低于模型组,差异均有统计学意义(P<0.05),且联合组小鼠的口腔溃疡指数、口腔上皮组织Caspase-3蛋白相对表达水平低于雌激素组,差异均有统计学意义(P<0.05).结论 雌激素结合康复新液在复发性口腔溃疡小鼠的应用能缓解组织损伤,抑制炎性因子的释放,降低口腔上皮细胞凋亡率,促进小鼠正常发育.

1 病例资料 患者,男,68岁,因"间断胸闷胸痛16 h"于2018年12月10日入院.患者16 h前无明显诱因出现胸闷、胸痛,为心前区压榨紧缩感,伴眩晕、大汗、恶心、呕吐,持续约30 min,经休息缓解.4 h前再次出现胸闷,伴一过性意识丧失,约半分钟后意识恢复,醒后无肢体活动障碍.急到我院就诊,测血压66/47 mmHg(1 mmHg=0.133kPa).心电图示窦性心动过速,104次/min,Ⅱ、Ⅲ、aVF可见Q波,STV4～6压低,左前分支传导阻滞以及房性期前收缩(图1).急查心肌损伤三项:肌酸激酶同工酶(CK-MB)80 ng/mL(正常值0～4.3 ng/mL),肌红蛋白(MYO)500 ng/mL(正常值＜107 ng/mL),肌钙蛋白Ⅰ(cTnⅠ)25.1 ng/mL(正常值0～0.4 ng/mL),以"急性心肌梗死"收入我科.入院查体:T 36.5℃,P 108次/min,R 20次/min,BP 92/56 mmHg;神志清,双肺呼吸音清,未闻及干湿啰音.心率112次/min,心律不齐,可闻及期前收缩,1～3次/min,心音可,各瓣膜听诊区未闻及病理性杂音;腹软,无压痛,肝脾肋下未及,双下肢无水肿.

自生物制剂（依那西普）于2004年经美国食品和药物管理局（Food and Drug Administration, FDA）批准用于治疗中、重度斑块状寻常型银屑病,生物制剂因其优越的疗效在临床上得到了广泛应用,尤其是重症、难治以及特殊类型银屑病。为使生物制剂能合理、安全、有效的应用于临床,提高患者生活质量,因此,制定一个详细的共识非常重要。本文通过对《中国银屑病生物治疗专家共识（2019）》解读,为临床医师采用生物制剂治疗银屑病提供帮助。

目的:探讨康复新液与他克莫司联合沙利度胺治疗口腔扁平苔藓(oral lichen planus,OLP)的临床疗效及安全性.方法:选择2017年12月-2020年1月就诊于我院的80例OLP患者,采用随机数字表法将其分为联合组和对照组,每组40例.两组均进行常规治疗,对照组使用0.1％的他克莫司软膏与康复新液治疗,联合组在对照组的基础上加用沙利度胺片,比较两组的临床疗效、治疗前后糜烂面大小、疼痛程度的变化以及不良反应的发生情况.结果:治疗后,联合组总有效率为90.00％,显著高于对照组(72.5％,P＞0.05);与治疗前相比,两组口腔糜烂面积和疼痛程度均显著降低(P＜0.05),且联合组口腔糜烂面积和疼痛程度显著低于对照组(P＜0.05);治疗期间,对照组出现1例不良反应,具体表现为轻微的黏膜烧灼痛,停药后两天后症状消失,不良反应发生率为2.5％,联合组出现2例不良反应,其中l例病变部位出现黏膜萎缩,1例出现色素沉着,不良反应发生率为5.0％,两组不良反应的发生率比较无显著差异(P＞0.05).结论:康复新液与他克莫司联合沙利度胺治疗口腔扁平苔藓的临床疗效明显优于康复新液与他克莫司治疗,其能明显降低粘膜糜烂面积和疼痛程度,且安全性高.

目的 探讨5-氨基酮戊酸联合红光的光动力疗法对ICR小鼠皮肤Ⅰ、Ⅲ型胶原蛋白表达的影响.方法 24只ICR小鼠随机分为空白对照组、单纯红光组和每只小鼠背部皮肤3块相等面积区域分别外敷3％、5％、10％的光敏剂.采用不同浓度光敏剂5-氨基酮戊酸光动力疗法作用于ICR小鼠背部皮肤,3组小鼠每2周给予一次相应处理,共3次.处理后第1、7、14、28天取同等大小ICR小鼠背部皮肤免疫组织化学染色制片检测Ⅰ、Ⅲ型胶原含量面积百分比.结果 与单纯红光组及3％、5％光动力组比较,10％光动力组促进ICR小鼠Ⅰ胶原增加作用更明显、持久(P<0.05).光动力组ICR小鼠较单纯红光组更早表现出Ⅲ型胶原含量增加,且10％光动力组ICR小鼠在第14天、28天Ⅲ型胶原含量增加较其他各组比较差异有统计学意义(P<0.05).结论 5-氨基酮戊酸联合红光的光动力疗法可促进ICR小鼠皮肤Ⅰ、Ⅲ型胶原的表达,对皮肤老化的改善具有一定积极作用.10％的5-氨基酮戊酸光动力疗法对ICR小鼠Ⅰ、Ⅲ型胶原蛋白的改善较低浓度光动力组及单纯红光组更明显,可能为治疗皮肤老化的适宜浓度.

目的 比较急性ST段抬高性心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者在急诊经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗中冠状动脉内分次注射与一次性注射重组人尿激酶原两种给药方式对术后心肌灌注及近期预后的影响.方法 选择2016-08 ～2017-10本院连续入选的102例接受急诊PCI的STEMI患者并随机分为两组:A组49例于导丝通过冠状动脉病变后、球囊扩张后、支架置入后分别于冠状动脉内注射重组人尿激酶原4、3、3 mL(共20 mg),B组53例于导丝通过冠状动脉病变后一次性向冠状动脉内注射重组人尿激酶原10 mL(共20 mg).联合术后心肌梗死溶栓试验(thrombolysis in myocardial infarction,TIMI)血流分级、TIMI心肌灌注分级(TIMI myocardial perfusion grade,TMPG)、术后90min ST段回落率(ST-segment resolution,STR)及术后第1天和第7天左室射血分数(left ventricular ejection fraction,LVEF)评估心肌灌注水平,比较术后第7天出血事件及术后3个月主要不良心脏事件(major adverse cardiac events,MACE)的发生.结果 两组患者术前TIMI血流分级、TMPG及术后第1天LVEF比较差异无统计学意义(P＞0.05).梗死相关动脉(infarct-related artery,IRA) PCI术后,与B组比较,A组TIMI血流分级(P=0.038)、TMPG(P=0.015)改善明显,术后90 min ST段回落明显(P =0.032),术后第7天LVEF也有所改善(P=0.001).两组术后第7天出血事件及术后3个月MACE发生率比较差异无统计学意义(P＞0.05).结论 对于行急诊PCI的急性STEMI患者,PCI术中分次给予重组人尿激酶原较一次性给予重组人尿激酶原能更好地改善心肌灌注,且不增加出血及MACE的发生率,最终改善预后.

OBJECTIVES:To develop a method to screen and quantify 10 common herbicides （paraquat, diquat, glyphosate, glufosinate, cyanazine, atrazine, metazachlor, acetochlor, chlorsulfuron, and metsulfuron） in blood.METHODS:With acetonitrile-water solution [V（acetonitrile）∶V（water）=3∶1] as protein precipitant, 10 common herbicides in blood were detected using ultra-high performance liquid chromatography-high resolution mass spectrometry （UPLC-HRMS）.RESULTS:All the 10 herbicides had good linearity in their linear range （coefficient of determination R2≥0.993）, with the recovery rates 67.4%-111.9%, the relative standard deviations 1.5%-10.8%, the accuracies 85.1%-106.1%, intra-day precisions 2.7%-13.5%, and inter-day precisions 3.3%-13.3%.CONCLUSIONS:This method is easy to operate with high recovery rates. It enables rapid and accurate qualitative screening and quantitative analysis of various herbicides in blood simultaneously.

Non-melanoma superficial skin tumors and precancerous lesions,mainly including Actinic keratosis,Basal cell carcinoma,Bowen's disease and Extramammary paget's disease,are common diseases in our country.The pathogenesis of these diseases is quite complex and usually related to ultraviolet radiation,chemical carcinogens,ionizing radiation and so on.However,the precise etiology still remains unclear.Currently,Mohs surgery is the preferred treatment for superficial skin tumors (except Actinic keratosis),because of the complete removal of tumor tissues and the minimized defect area of skin.The other treatments include photodynamic therapy,radiation therapy,chemotherapy,cryotherapy,laser light and topical applications of imiquimod or 5-fluorouracil.However,the benefits of single therapy are usually limited.In contrast,comprehensive treatment can improve both the cure rate and patients' satisfication rates while reducing the adverse reactions.Comprehensive treatment is a systematically individualized treatment,rather than simply adding several treatment methods together.This paper reviewed the new development of comprehensive treatment for non-melanoma superficial skin tumors and precancerous lesions.

BACKGROUND:Studies have found that sodium arsenite can cause the malignant transformation and tumorigenicity of HaCaT cels, but whether low concentrations of sodium arsenite can cause the malignant transformation is rarely reported. <br> OBJECTIVE:To study the effect of sodium arsenite on the malignant transformation of human immortalized keratinocyte cel lines. <br> METHODS:HaCaT cels were treated with different concentrations of sodium arsenite. MTT assay was used to determine the effect of sodium arsenite on HaCaT cel morphology and proliferation, flow cytometry used to detect the effect of sodium arsenite on HaCaT cel cycle, and soft agar colony formation experiments assay used to determine the effect of sodium arsenite on HaCaT cel colony formation capacity. <br> RESULTS AND CONCLUSION: HaCaT cels grew wel when the concentration of sodium arsenite was 5 mol/L, but the cel growth was inhibited under intervention with 10 and 50 mol/L sodium arsenite. HaCaT cels treated with 0.1 mol/L sodium arsenite were passaged to the 20th generation, and cel morphology had no notable changes; cels at passage 25 exhibited enlarged size and multiple nucleoli, which had a continued proliferation trend. Compared with the primarily cultured cels, 0.1 mol/L sodium arsenite-treated HaCaT cels at passages 15 and 25 had an increased proportion at S phase and G2/M phase, with strengthened proliferation ability and increased colony-forming efficiency, and moreover, the proliferation ability and colony-forming efficiency of passage 25 cels were higher than those of passage 15 cels. These experimental data show that high concentrations of sodium arsenite reduce HaCaT cel viability, and low concentrations of sodium sulfite have a certain influence on the morphology, cel cycle, proliferation ability and colony-forming efficiency of HaCaT cels, and moreover, the proliferation ability and colony-forming efficiency of human immortalized keratinocytes wil be strengthened with the increase of passage.

Objective To evaluate effects of thalidomide on proliferative activity of as well as expressions of collagenⅠα1 andⅢα1 mRNAs and collagenⅠα1 protien in human dermal fibroblasts(HDFs), and to preliminarily explore the potential role of thalidomide in the fight against dermal fibrosis. Methods HDFs were isolated from the foreskin of a healthy young man, and subjected to primary culture. The fourth?passage HDFs were used in the following experiment. Some HDFs were divided into 3 groups to be treated with 10?3, 10?4 and 10?5 mol/L thalidomide respectively, and other HDFs treated with DMEM alone served as the blank control group. After 24?hour culture, cell counting kit?8 (CCK?8)assay was performed to evaluate the proliferative activity of HDFs, fluorescence?based quantitative PCR to measure the mRNA expressions of collagen Ⅰα1 and Ⅲα1, and Western?blot analysis to determine the protein expression of collagenⅠα1. Results Compared with the blank control group, the 10?3?and 10?4?mol/L thalidomide groups both showed significantly decreased cell survival rates(77.40%± 4.25%and 88.56%± 6.43%vs. 100.00%± 6.74%, both P<0.05), but the 10?5?mol/L thalidomide group showed no significant difference(96.66%± 1.098%, P>0.05). Compared with the blank control group, the 10?3?, 10?4?and 10?5?mol/L thalidomide groups all showed significantly lower mRNA and protein expressions of collagen Ⅰα1(mRNA:0.279 ± 0.025, 0.427 ± 0.040 and 0.658 ± 0.032 vs. 1.016 ± 0.003;protein:0.279 ± 0.020, 0.926 ± 0.048 and 1.523 ± 0.027 vs. 1.773 ± 0.059;all P<0.05). In addition, the mRNA expressions of collagenⅢα1 were also significantly weaker in the 10?3?, 10?4?and 10?5?mol/L thalidomide groups compared with the blank control group(0.551 ± 0.039, 0.756 ± 0.025 and 0.826 ± 0.018 vs. 0.988 ± 0.012, all P<0.05). Conclusion Thalidomide within a certain range of concentrations can inhibit the proliferation of HDFs, as well as expressions of collagenⅠα1 mRNA and protein and collagenⅢα1 mRNA.

目的观察复因冷敷保湿修复敷料（喷）联合皮肤止痒脱敏膜对高频电刀治疗尖锐湿疣创面愈合时间的影响。方法 140例尖锐湿疣患者,外阴部位80例,肛周部位60例。患者随机分为治疗组和对照组,每组70例。治疗组为尖锐湿疣患者经高频电刀治疗后创面使用复因冷敷保湿修复敷料喷和皮肤止痒脱敏膜（商品名蓝科肤宁）,对照组创面单独使用蓝科肤宁,观察临床效果。结果治疗组疗效优于对照组,差异有统计学意义（P＜0.05）。结论复因冷敷保湿修复敷料喷联合蓝科肤宁明显促进高频电刀治疗后创面愈合,缩短愈合时间,减轻患者痛苦,值得临床推广。

Objective To investigate the influence of stromal interaction molecule 1 ( STIM1 ) and osteoprotegerin ( OPG) on in-stent restenosis ( ISR) in patients with acute coronary syndrome ( ACS) complicated with type 2 diabetes mellitus (T2DM) after percutaneous coronary intervention ( PCI) .Methods We enrolled 100 patients with ACS complicated with T2DM who were admitted into the Department of Cardiology of the Third Hospital of Hebei Medical University from October 2012 to October 2013.PCI was undertaken successfully on all the subjects .Eight months after surgery , coronary arteriography was conducted again.According to whether ISR occurred , we divided the subjects into two groups: ISR group ( n=35) and control group (n=65) .General data of the 100 subjects were recorded, including gender, age, hypertension and smoking; before PCI, we tested hs-CRP, blood lipid and blood glucose; after PCI, we determined STIM1 and OPG levels.Results The two groups were not significantly different (P>0.05) in age, gender, smoking rate, prevalence of hypertension.The two groups were not significantly different ( P >0.05 ) in TC, TG, HDL-C, LDL-C and FPG; the two groups were significantly different (P<0.05) in the levels of hs-CRP, STIM1 and OPG.Multivariate logistic regression analysis showed that hs-CRP, STIM1 and OPG had significant influence on ISR in subjects after PCI ( P<0.05 ) .Gonclusion STIM1 and OPG are risk factors for patients with ACS complicated with T 2DM after PCI.