目的:探讨单亲家庭大学生婚姻态度、安全感和自尊之间的关系.方法:选取河北某高校在校大学生435人(单亲家庭199人,双亲家庭236人),采用婚姻态度量表(MAS)、安全感量表(SQ)、自尊量表(RSES)进行调查.结果:单亲家庭大学生的MAS、SQ、RSES得分均低于双亲家庭大学生(均P＜0.001).单亲家庭大学生的SQ总分与MAS总分正向关联(β=0.40),RSES得分与MAS总分正向关联(β=0.61),RSES得分在SQ总分与MAS总分中起调节作用(β=0.02,P＜0.001).结论:单亲家庭大学生的婚姻态度与安全感、自尊有关.

目的 分析亲子音乐干预对新生儿重症监护病房(NICU)出院早产儿智能、母亲产后抑郁情绪和亲子关系的影响,为促进早产儿智能发育及改善母亲心理健康提供临床实践经验和循证依据.方法 选择2020年5-12月在唐山市妇幼保健院儿童康复科门诊接受随访的纠正胎龄40～44周的早产儿61例为研究对象,采用随机数字表法将其分为亲子音乐组(30例)和对照组(31例).对照组早产儿接受常规家庭指导,亲子音乐组早产儿在对照组的基础上进行亲子音乐干预.干预时间为15～20 min/d,为期3个月.干预前后用Gesell发育量表(GDS)对早产儿进行评估,用爱丁堡产后抑郁量表(EPDS)和母亲客体关系量表[MORS(Child)]对其母亲进行评估.结果 干预后亲子音乐组GDS评价在适应性、大运动和语言方面得分均显著高于对照组,差异有统计学意义(t=3.139、3.113、3.612,P＜0.05);干预后两组家长EPDS评分较干预前均降低(t=12.286、16.102,P＜0.05),且亲子音乐组得分较对照组得分下降更多(t=2.545,P＜0.05);干预后两组家长MORS(Child)得分较干预前均提高(t=13.871、9.046,P＜0.05),且亲子音乐组得分较对照组提高更多(t=3.292,P＜0.05).结论 亲子音乐干预对NICU出院早产儿的智能有促进作用,并且有利于改善早产儿母亲抑郁和增强亲子关系.

目的 探讨朗读训练对改善慢性精神分裂症患者阴性症状的疗效,为慢性精神分裂症患者的康复治疗提供新方法.方法 2020年3～6月选择河北省某精神病医院慢性精神分裂症患者90例,随机分成观察组和对照组,对照组给予常规综合治疗,观察组在常规综合治疗基础上加朗读训练.采用阳性与阴性量表(PANSS)和精神科护理观察量表(NOSIE)在干预前后进行问卷测评,用PANSS阴性症状得分作为干预效果的评定指标,NOSIE量表得分作为补充信息.两组患者均在医院接受4个月的综合治疗.结果 ①与干预前比较,两组患者PANSS阳性得分、阴性得分、一般病理得分和总分都显著降低(P<0.001).干预后,两组患者PANSS得分比较,观察组阴性症状得分和病情总估计得分显著降低(t=-3.355、P<0.05,t=-2.571、P<0.01);而阳性得分和一般病理得分差异不显著.②与干预前比较,两组患者NOSIE病情总估计、积极因素、消极因素得分均有显著差异(P<0.001).干预后,观察组和对照组比较,观察组NOSIE病情总估计得分和总积极因素得分显著提高(t=8.421、P<0.001,t=8.794、P<0.001);而总消极因素得分差异不显著.结论 朗读训练对改善慢性精神病患者的阴性症状有较好疗效,是一种有效的康复治疗手段.

Objective:To investigate the effect of bilateral repetitive transcranial magnetic stimulation (rTMS) on the pre-attentive processing of methamphetamine addicts.Methods:Forty methamphetamine addicts were screened and equally divided into the intervention group and the control group by random number table method.The intervention group was treated with bilateral simultaneous stimulation with 10 Hz on the left DLPFC and 1 Hz on the right DLPFC with 7 days of continuous intervention.The same scheme was used to intervene the control group, but with pseudo-stimulation. The changes of amplitude and latency of mismatch negative wave(MMN) before and after intervention were compared. SPSS 24.0 software was used for statistical analysis. Independent sample t-test was used for inter group comparison, and paired sample t-test was used for intra group comparison before and after intervention. Results:Before rTMS, there were no significant differences in MMN(F3, Fz, F4) amplitude (intervention group: (-0.90±0.28)μV, (-0.98±0.19)μV, (-0.96±0.19)μV; control group: (-0.92±0.21)μV, (-0.89±0.20)μV, (-0.94±0.16)μV)and latency(intervention group: (184.16±33.07)ms, (179.20±25.35)ms, (184.95±28.22)ms; control group: (184.91±26.96)ms, (180.99±25.29)ms, (181.55±23.19)ms) between the two groups (all P>0.05). After the intervention, there were significant differences in MMN(Fz, F4) amplitude(intervention group: (-1.38±0.16)μV, (-1.17±0.19)μV; control group: (-0.91±0.17) μV, (-0.99±0.16)μV) between the two groups (both P<0.01), but there were no significant differences in MMN (F3) amplitude(intervention group: (-1.01±0.59)μV; control group: (-0.80±0.50)μV), and in MMN (F3, Fz, F4) latency(intervention group: (177.38±26.45)ms, (172.17±23.87)ms, (179.84±23.60)ms; control group: (182.08±24.95)ms, (177.94±21.30)ms, (179.18±21.62)ms)between the two groups (all P>0.05). There were statistically significant differences in MMN( Fz, F4) amplitude (before-intervention: (-0.98±0.19)μV, (-0.96±0.19)μV; after-intervention: (-1.38±0.16)μV, (-1.17±0.19)μV)before and after intervention in the intervention group (both P<0.05), but there was no significant difference in MMN(F3) amplitude(before-intervention: (-0.90±0.28)μV; after-intervention: (-1.01±0.59)μV)before and after intervention in the intervention group ( P>0.05), and there were statistically significant differences in MMN(F3, Fz, F4) latency (before-intervention: (184.16±33.07)ms, (179.20±25.35)ms, (184.95±28.22)ms; after-intervention: (177.38±26.45)ms, (172.17±23.87)ms, (179.84±23.60)ms)before and after intervention in the intervention group(all P<0.05). After pseudo-stimulation, there were no statistically significant differences in MMN( F3, Fz, F4) amplitude(before-intervention: (-0.92±0.21)μV, (-0.89±0.20)μV, (-0.94±0.16)μV; after-intervention: (-0.80±0.50)μV, (-0.91±0.17)μV, (-0.99±0.16)μV)and latency (before-intervention: (184.91±26.96)ms, (180.99±25.29)ms, (181.55±23.19)ms; after-intervention: (182.08±24.95)ms, (177.94±21.30)ms, (179.18±21.62)ms) before and after intervention in the control group (all P>0.05). Conclusion:After repeated transcranial magnetic stimulation, the pre-attentive processing of the intervention group is improved, which shows that bilateral simultaneous stimulation of the rTMS program is effective.

为完善高校大学生心理健康教育课程建设和发展,充分发挥课程培养人才的功能.课程组依据OBE的教育理念,借鉴连结主义教学设计模型,通过线上搭建优质视频资源网络教学平台,线下打造精品线下体验实践活动,构建大学生心理健康教育混合式课程体系.这一课程体系有效的契合了现代教育的发展趋势,激发了大学生的参与性和体验性,体现了培养适应未来变化社会的人才需求.

随着新媒体持续、深入的发展,网络中充斥着海量的新闻信息,然而新媒体新闻传播内容和方式易被受众偏好所影响,进而对社会认知产生影响.受众之所以会表现出对某一类信息的阅读偏好,是与个体的人际信任相关.本研究以大学生为研究对象,采用人际信任量表评定其信任水平,确定高信任水平组和低信任水平组;以社会新闻为材料,运用眼动追踪技术,记录新闻阅读的注视时间、注视次数等眼动指标数据,采用2(信任水平:高/低)×2(新闻性质:正性/负性)混合设计(信任水平为组间变量,新闻性质为组内变量),探索人际信任水平与新闻阅读选择偏好的关系.结果表明:(1)在平均注视时间上,新闻性质主效应显著,大学生明显偏好阅读负性新闻.(2)在正文注视时间上,人际信任水平与新闻性质交互作用显著,表现为人际信任水平低的大学生偏好负性新闻的倾向性更明显.

以华北理工大学应用心理学专业建设为例,分析了医学背景下应用心理学专业培养面临的问题;从培养目标设定、课程设置、实践教学环节安排等方面论述了学校在医学背景下培养应用心理学专业人才的实践和体会.同时也分析了在人才培养过程中遇到的问题,并提出了解决问题的措施.

本文探讨实验心理学以创新创业为导向的教学改革,针对目前实验心理学的教学内容、教学方式、评价体系等一系列存在的问题进行思考并找到其新突破,旨在为提高实验心理学教学质量、培养创新创业型人才提供参考.

目的 探讨乙型肝炎后肝硬化并发原发性肝癌患者的乙型肝炎病毒指标定量检测的变化,以期为乙型肝炎后肝癌的早期诊断提供临床指导意义.方法 采用回顾性分析方法,选取2015年2月—2016年2月在华北理工大学附属医院及唐山市传染病医院住院的乙型肝炎后肝硬化并发肝癌的患者59例,选择82例同期住院的单纯乙型肝炎后肝硬化患者作为对照.分析两组乙肝病毒标志物HBsAg、HBsAb、HBeAg、HBeAb、HBV DNA的差异.结果 肝硬化并发肝癌组HBsAg、HBeAg的含量低于单纯肝硬化组,差异有统计学意义(P<0.05),两组患者HBsAb、HBeAb及HBV DNA的含量差异无统计学意义(P>0.05).结论 随着乙型肝炎后肝硬化病情的进展,HBsAg、HBeAg含量可能会逐渐降低,但这并不意味着病情得到控制或好转,有可能进展为肝癌,所以对病毒载量较低的乙型肝炎后肝硬化患者仍需积极抗病毒治疗,且应至少3个月复查1次乙型肝炎病毒标志物定量检测,以提高早期肝癌的检出率.

在高科技飞速发展的今天,智能手机等移动终端无疑成为了人们日常生活补课分割的重要组成部分.然而,伴随着社会的飞速发展的,是人们日益增长的社会和生活压了,人们的心理健康状态也越来越差.我国在心理咨询与知识方面的手机应用软件尚处在起步阶段,其发展前景也是一片大好.本文设计的"E-Heart"心理咨询与知识APP正是基于当今社会移动终端飞速发展的优势,结合各大高校心理咨询需求,旨在解决当前社会心理咨询效率低下,普及面狭窄等实际问题,从而从根本上提高人们对心理咨询以及心理学知识的重视.

目的:探讨影响唐山大地震幸存者心理韧性与创伤后成长的关系,及是否受伤在心理韧性与创伤后成长关系中的调节作用.方法:采用创伤后成长问卷、心理韧性量表以及一般人口学资料量表,对256名唐山大地震幸存者施测.结果:创伤后成长各维度及总分与心理韧性呈正相关(r =0.248～0.572,P＜0.001),心理韧性对于创伤后成长具有显著预测作用(P＜0.001),是否受伤在心理韧性与创伤后成长的关系中具有负向调节作用.结论:心理韧性是唐山大地震幸存者创伤后成长的重要影响因素,其对创伤后成长的影响受到是否受伤情况的影响.

血友病是临床上最常见的X染色体连锁隐性遗传性出血性疾病,分为血友病A (hemophilia A,HA)及血友病B(hemophilia B,HB),前者血浆内缺乏凝血因子Ⅷ(F Ⅷ),后者缺乏凝血因子Ⅸ(FⅨ).血友病患者因凝血功能障碍,一直以来被认为是手术禁区,但随着凝血功能的评估和替代治疗的开展,越来越多的血友病患者成功实施了手术,但围手术期最佳替代治疗的剂量和疗程仍处于探讨中.现将我院2011-02-2014-05收治的4例血友病患者围手术期替代治疗方案总结如下,旨在探讨不同手术的围手术期凝血因子的合理替代剂量、疗程及安全性.

病例1:男,36岁.主因发热10 d于2012年11月26日首次入我院.入院查体:体温 38℃,脉搏 102次/min,呼吸 22 次/min,血压 120/70 mmHg(1 mmHg=0.133 kPa).无贫血貌,全身皮肤黏膜无出血点,心肺腹未见明显异常,胸骨轻压痛,双下肢无水肿,病理反射阴性.血常规示:WBC 86.5×109/L,Hb 132 g/L,PLT 32×109/L;外周血细胞分类示幼稚细胞占80%,可见Auer小体;血浆凝血酶原时间(PT)17.0 s,INR1.48,纤维蛋白原(FIB)1.06 g/L,纤维蛋白原降解产物(FDP)和D二聚体(+).骨髓涂片提示早幼粒细胞占85%;PML-RARα基因阳性及免疫分型示MPO和CD117阳性,CD34和HLA-DR阴性.诊断为急性早幼粒细胞白血病合并弥散性血管内凝血(DIC).

Objective To investigate the therapeutic effect of Somatostatin with Salviae in treatment of upper gastrointestinal bleeding and portal vein thrombosis in patients with liver cirrhosis.Methods Totally 96 patients with liver cirrhosis treated in the Affiliated Hospital of North China University of Science and Technology and Tangshan City Hospital for Infectious Diseases from January 2010 to January 2016 were enrolled.They were divided into four groups,namely control group (received symptomatic and supportive treatment),Somatostatin group (received symptomatic and supportive treatment and Somatostatin),Salviae group (given symptomatic and supportive treatment and Salviae),and combined treatment group (accepted symptomatic and supportive treatment,Somatostatin and Salviae) with 24 cases in each group.The changes of ALT,AST,CHE,liver function Child-Pugh classification,PT,FIB,PLT,PVD and prognosis were observed after treatment.Results ALT,AST,CHE,liver function Child-Pugh classification,PT,FIB,PLT and PVD in the Somatostatin,Salviae and combined treatment groups were significantly different from those in the control group (P ＜ 0.05);the reduction was most obvious in the combined treatment group.The indexes of the combined treatment group were significantly different from those of the Somatostatin and Salviae groups (P ＜ 0.05).Conclusions Combination of Somatostatin and Salviae has better synergistic therapeutic effect in the treatment of upper gastrointestinal bleeding and portal vein thrombosis in patients with liver cirrhosis,which is superior to using western medicine alone.

Objective To explore the status of minor children of the land-lost farmers under the background of new urbanization on mental health,self-esteem,and self-efficacy and the relationships among them.Methods The mental health test scale,self-esteem scale and general self-efficacy scale questionnaire survey were conducted among 2188 landless peasants minor children of national pilot areas of new urbanization in Hebei province.Results Minor child mental health problems of the land-losing farmers overall detection rate was 30.00％,the detection rate of learning anxiety was the highest (69.39％).The MHT total score (t =7.323,P =0.000) and the scores of all the components of the landless peasants were higher than those of the non landless peasants (t =2.588～8.001,P＜0.01),and the differences were statistically significant.The new urbanization under the background of the ground with the land-lost farmers minor children in general self-efficacy had significant difference (t =5.196,P＜0.01).Self-esteem and self-efficacy,respectively,with total score of mental health and its each dimension had significant negative correlation,self-esteem and self-efficacy had significant positive correlation.Self-efficacy in partial intermediary played an effect between self-esteem and mental health (beta =-0.091,-0.308,P＜0.01).Conclusions The mental health level of landless peasants' minor children under the background of the new urbanization is low;but the land-lost farmers children self-efficacy is significantly higher than the landlost farmers children's self-efficacy.The higher self-esteem and self-efficacy,the higher the level of mental health;self-esteem can affect mental health through self-efficacy.

目的 探讨双环醇联合异甘草酸镁治疗药物诱导自身免疫性肝炎的临床效果.方法 药物诱导自身免疫性肝炎患者78例,根据治疗方法分为观察1组,观察2组和对照组各26例.对照组给予保肝等支持治疗;观察1组在对照组治疗基础上给予双环醇口服;观察2组在观察1组治疗基础上给予异甘草酸镁静脉滴注;3组疗程均为4周.比较3组治疗前、治疗2、4周时谷丙转氨酶(glutamate pyruvate transaminase,GPT)、谷草转氨酶(glutamic-oxal(o)acetictransaminase,GOT)、球蛋白、碱性磷酸酶、总胆红素、透明质酸、Ⅲ型前胶原、层黏连蛋白、Ⅳ型胶原水平变化.结果 治疗4周时观察1组、观察2组和对照组GPT[(95±43),(48±27),(163±65)u/L]、GOT[(82±34),(46±22),(92±56)u/L]、球蛋白[(34±19),(27±12),(42±27)g/L]、碱性磷酸酶[(123±42),(86±43),(176±48) u/L]、总胆红素[(36.6±25.4),(27.1±18.4),(63.2±28.7)μmol/L]、透明质酸[(175.4±68.5),(96.5±58.2),(186.2±96.6)μg/L]、Ⅲ型前胶原(143.4±52.6),(115.3±47.6),(167.6±89.5)μg/L]、层黏连蛋白[(128.3±68.1),(97.5±42.6),(134.6±72.5)μg/L]、Ⅳ型胶原[(103.3±46.7),(86.5±34.8),(133.5±47.2) μg/L]水平均低于治疗前[GPT(246±78),(262±81),(264±85)u/L;GOT(169±72),(173±67),(186±65)u/L;球蛋白(72±34),(76±37),(75±42)g/L;碱性磷酸酶(262±81),(259±92),(254±76)u/L;总胆红素(72.4±39.3),(74.5±40.1),(78.5±36.2) μmol/L;透明质酸(248.2±105.3),(256.3±107.4),(253.7±112.1)μg/L;Ⅲ型前胶原(239.6±84.7),(242.5±91.4),(236.4±86.7)μg/L、层黏连蛋白(193.6±79.4),(186.2±81.7),(187.5±85.2)μg/L;Ⅳ型胶原(197.3±78.1),(210.5±57.6),(205.4±67.2)μg/L](P＜0.05);且观察2组治疗4周后各指标水平低于观察1组和对照组,观察1组低于对照组,差异均有统计学意义(P＜0.05).结论 药物诱导自身免疫性肝炎患者应用双环醇联合异甘草酸镁治疗可明显改善肝功能和肝纤维化指标.

目的 探讨生长抑素联合早期血液灌流对急性重症胰腺炎(severe acute pancreatitis,SAP)的治疗作用.方法 108例SAP患者随机分为生长抑素组、血液灌流组和联合组,每组36例;生长抑素组给予常规治疗+生长抑素治疗,血液灌流组给予常规治疗+血液灌流治疗,联合组给予常规治疗+生长抑素+血液灌流治疗.比较3组治疗第1、3、7天血清白细胞介素(interleukin,IL)-10、IL-18、肿瘤坏死因子(tumor necrosis factor,TNF)α水平的变化.结果 生长抑素组治疗第1、3、7天IL-10为[(10.78±0.52)、(19.27±1.62)、(17.25±1.52)ng/L],IL-18为[(476.27±185.12)、(376.34±98.42)、(204.81±84.32)ng/L],TNF-α为[(197.28±51.24)、(121.38±29.17)、(91.27±29.35)ng/L],与血液灌流组[(IL 10(11.03±0.49)、(20.13±1.46)、(18.13±1.37)ng/L,IL-18(455.87±172.36)、(367.25±87.32)、(187.34±65.16)ng/L,TNF-α(211.35±49.28)、(123.46±27.15)、(87.38±25.41)ng/L]比较差异无统计学意义(P＞0.05);联合组治疗第3、7天IL 10[(21.85±1.71)、(19.85±1.28) ng/L]高于生长抑素组和血液灌流组,IL 18[(352.28±71.28)、(165.17±49.31)ng/L]及TNF-α[(105.37±25.42)、(74.32±21.49)ng/L]低于生长抑素组和血液灌流组,差异有统计学意义(P＜0.05);联合组住院时间[(27±8)d]较生长抑素组[(35±9)d]和血液灌流组[(34±10)d]短(P＜0.05),病死率(2.8％)低于生长抑素组(13.9％)和血液灌流组(11.1％)(P＜0.05),生长抑素组与血液灌流组比较差异无统计学意义(P＞0.05).结论 生长抑素联合早期血液灌流可有效清除SAP患者血清IL-18、TNF-α,阻断炎症级联反应,对SAP有较好治疗作用.

Objective To investigate the causes and clinical features of liver cirrhosis complicated by upper gastrointestinal bleeding in Tangshan,China in the past 5 years,and to provide a reference for clinical treatment.Methods A total of 462 patients with liver cirrhosis complicated by upper gastrointestinal bleeding who were hospitalized in The Affiliated Hospital of North China University of Science and Technology,Tangshan Municipal Hospital of Infectious Diseases,Tangshan Workers' Hospital,and The Affiliated Hospital of Kailuan Group Limited Liability Corporation were enrolled,and all the patients underwent gastroscopy to clarify the cause of bleeding.The association between the cause of bleeding and Child-Pugh class was analyzed.The chi-square test was used for comparison of categorical data.Results Among the causes of liver cirrhosis complicated by upper gastrointestinal bleeding,esophagogastric variceal bleeding,portal hypertensive gastropathy,hepatogenic ulcer,acute gastric mucosal lesion,and mixed type accounted for 52.16％,27.71％,11.04％,4.11％,and 3.25％,respectively,and other causes accounted for 1.73％.There were significant differences in Child-Pugh class between the patients with different causes (x2 =30.12,P =0.007).Conclusion Among the causes of liver cirrhosis complicated by upper gastrointestinal bleeding,esophagogastric variceal bleeding is the most common one,followed by portal hypertensive gastropathy.The cause of bleeding is associated with Child-Pugh class.

Objective To explore the mental health status of minor children of land-lost farmers under the background of new-type urbanization.Methods From March to May in 2016,by cluster sampling method and taking class as a unit,1 200 minor children of land-lost farmers from 4 national and provincial pilot areas of new-type urbanization including Shijiazhuang,Dingzhou,Zhangbei and Qian'an of Hebei Province were selected as the observation group,and meanwhile,1 200 the minor children of non-landless farmers according to the distribution of important variables such as area,gender and learning stage were selected as the control group.By questionnaire survey method,the minor children's basic situation and mental health status were investigated,and the mental health status was tested by mental health test(MHT),including 8 dimensional scales,namely learning anxiety(A),anxiety to people(B),loneliness tendency(C),self-accusation tendency(D),allergic tendency(E),physical symptoms(F),panic tendency(G),impulsive tendency(H).A total of 1 200 questionnaires were sent out in both groups.1 150 effective questionnaires were collected in observation group and the effective response rate was 95.8%.While 1 038 effective questionnaires were collected in control group and the effective response rate was 86.5%.Results The detection rate of learning anxiety,anxiety to people,allergic tendency,physical symptoms,panic tendency,impulsive tendency and overall mental health problems of the children in observation group was significantly higher than that in control group(P<0.05).There was no ignificant difference in detection rate of loneliness tendency and self-accusation tendency between two groups(P>0.05).The score of learning anxiety,anxiety to people,loneliness tendency,self-accusation tendency,allergic tendency,physical symptoms,panic tendency,impulsive tendency and total score of mental health of the children in observation group were significantly higher than that in control group(P<0.05).There was no significant difference in detection rate of learning anxiety,loneliness tendency,allergic tendency,physical symptoms and impulsive tendency among children with different gender of land-lost farmers(P>0.05).The detection rate of anxiety to people,self-accusation endency,panic tendency,overall mental health problems of underage girls of land-lost farmers was significantly higher than that of underage boys of land-lost farmers(P<0.05).There was no significant difference in the detection rate of learning anxiety of minor children of land-lost farmers in different learning stages(P>0.05).The detection rate of anxiety to people,loneliness tendency,allergic tendency,physical symptom,panic tendency,impulsive tendency and overall mental health problems of junior school students of land-lost farmers was significantly higher than that of elementary school students of land-lost farmers,while their detection rate of self-accusation tendency was ignificantly lower than that of elementary school students of land-lost farmers(P<0.05).Conclusion The mental health status of minor children of land-lost farmers is poor,and their learning anxiety problems are obviousThe overall mental health status of girls is worse than that of boys and the overall mental health status of junior school students is worse than that of primary school students.

血友病患者在行口腔手术时有较高出血风险，围术期需充足凝血因子替代治疗防止术中及术后出血。血友病B在血友病分类中较少见，且凝血因子Ⅸ获取受限，现将1例血友病B患者在低剂量、短疗程凝血因子替代治疗下成功实施拔牙术及瘘管修补术报告如下。