目的 观察在不同糖化血红蛋白(HbA1c)水平下,高海拔对糖尿病视网膜病变(DR)患者眼部多普勒血液流变学参数(CDFI)的影响.方法 选择 2015 年 1 月至 2020 年 12 甘肃省第二人民医院(西北民族大学附属医院)及甘南藏族自治州人民医院眼科及内分泌科非增生性DR患者 220 例(220 只眼),将高海拔组[高原藏族居民,110 例(110 只眼)]和低海拔组[中低海拔居民,110 例(110 只眼)]再依据HbA1c水平的不同分别分为观察组和对照组,每组各 55 例(55 只眼),观察组HbA1c≥8.0 mmol/L及以上,对照组HbA1c<8.0 mmol/L,观察不同海拔对DR患者眼部CDFI的影响.结果 高海拔观察组与对照组比较,视网膜中央动脉(CRA)、眼动脉(OA)及睫状后短动脉(PCA)的收缩峰值血流速度(PSV)相对较低,搏动指数(PI)及阻力指数(RI)有所增加,差异有统计学意义(P<0.05);低海拔观察组与对照组比较,CRA、OA的PSV较低,PCA的PSV较高,而PI及RI均相对较低,差异均有统计学意义(P<0.05);高海拔观察组与低海拔观察组比较CRA、OA及PCA的PSV较低,PI及RI较高,差异有统计学意义(P<0.05).结论 当机体高海拔暴露且HbA1c≥8.0 mmol/L时,DR患者的眼部CDFI有显著的异常.

目的:观察"九宫格"眼动训练法对眼眶病术后双眼单视功能建立的作用;方法:收集在我院眼科住院的眼眶骨折及眼眶肿瘤患者术后伴有眼肌功能不良的病例146例,随机分为治疗组共76例及对照组70例,治疗组进行"九宫格"眼动训练法,对照组进行患者随意眼球转动锻炼.对两组病例术后1周、2周、3周及4周采用同视机进行立体视觉、融合功能及斜视度检查取九个方位的平均数,对术后2周、3周及4周斜视度变化的数据采用统计学方法进行对比分析,判断其差异性.结果:以同视机检查的两组术后1周的斜视度为基数(p=0.06),术后2周治疗组

甲状腺相关眼病（Thyroid associated ophthalmopathy，TAO）是由多因素所致的一种自身免疫性疾病。其病因复杂，发病机制未完全阐明。近年来，国内外不断有学者提出各种治疗TAO的新型手术方法，虽仍尚未发现单一特效的治疗方法，但在手术目的、手术方案的选择、术中及术后效果的要求、术式、新型手术辅助技术等方面均有不同程度的改变及优化，本文就近年来TAO的眼眶减压术治疗的研究进展进行综述，希望通过归纳总结，理清TAO治疗方法观念的改变及技术的优化，更好的为临床医师及患者服务。

甲状腺功能障碍性视神经病变(dysthyroid optic neuropathy,DON)是甲状腺相关眼病的严重并发症之一.DON由于多病因导致眶内容物增多、眶内压增高,如延误治疗会造成不可逆性视力丧失.及时行眼眶减压术降低眶内压、减弱疾病活动性是治疗DON抢救视力、改善眼突度等的关键.眼眶减压术包括眼眶眶壁去除减压术、眶内脂肪切除减压术等.近年术式有所改进,包括深外侧壁减压术、内外壁平衡减压术、三壁最大化眶减压术、微创硬膜外眼眶减压术、鼻内镜下不同入路眶壁减压术、计算机辅助减压术、多种术式联合减压等,以期得到更好的治疗效果.

目的 观察逍遥散加味联合曲安奈德球内注射治疗糖尿病黄斑囊样水肿(DME)的临床疗效.方法 选取DME患者40例、79只眼,采用随机数字表法分为2组.对照组20例、40只眼予曲安奈德球内注射治疗,治疗组20例、39只眼在对照组治疗方法的基础上联合逍遥散加味口服治疗.2组分别在治疗前及治疗后1,4,8周,行视力、黄斑视网膜厚度检查,并根据此2项指标判定2组的临床疗效.结果 治疗组治疗后1,4,8周视力明显升高,黄斑视网膜厚度明显减小,与治疗前比较差异均有统计学意义(P＜0.05);治疗后4,8周,治疗组视力明显高于对照组,黄斑视网膜厚度明显小于对照组,2组比较差异均有统计学意义(P＜0.05).治疗后1,4,8周,对照组总有效率分别为70.0％,55.0％,35.0％,治疗组分别为66.7％,82.0％,76.9％,2组治疗后4,8周总有效率比较差异均有统计学意义(P＜0.05).结论 在曲安奈德球内注射的基础上联合逍遥散加味口服,可以明显改善患者的视力,减轻视网膜水肿,解决了单纯采用曲安奈德球内注射治疗远期疗效不佳的问题,取得了满意的临床疗效,且安全性良好.

目的 观察"逍遥散加味"对糖尿病视网膜病变(DR)黄斑囊样水肿血流动力学的影响.方法 该研究2015年3月—2017年3月期间选择DR患者40例80只眼,随机分为两组,在曲安奈德球内注射基础上加用逍遥散加味口服治疗者为研究组,常规使用曲安奈德球内注射治疗者为对照组,对两组治疗效果进行分析比较.结果 两组结果对照患眼的眼动脉、视网膜中央动脉、睫状后动脉的血流参数治疗后均有明显的改善,经统计学处理差异有统计学意义(P<0.05).结论 "逍遥散加味"对糖尿病视网膜病变患者视网膜血流动力学指标有明显的改善作用.

Objective To observe the effects of central retinal thickness of function among high altitude Tibetan residents with non-proliferative diabetic retinopathy.Methods Ninety cases (180eyes) of both Tibetan plateau residents (high altitude group) and Han Chinese residents in low altitude (low altitude group) with non-proliferative diabetic retinopathy patients were selected from January 2015 to June 2016,excluding the central retina significnt bleeding,oozing and significant other retinopathy.Based on the thickness of central retinal by optical coherence tomography (OCT,cirrus400 Zeiss) examination (center lmm,1-3mm,3-6mm straight by range),patients from different altitudes were re-divided into two groups of normal central retinal thickness group and abnormal group with 45 patients (90) of each group.Function of central retinal thickness of the patients were observed including ERG data,angiography data,f-ERG in dark-adapted rod,the mixed reaction cones,cone response,flashing light 30Hs reaction,VEP indicators and correlation between these were observed and analyzed.Results Central retinal thickness of the normal central retinal average thickness of 276.4-304.9 um;high altitude group central retinal thickness of normal and abnormal group Max-R (dark-adapted rod maximal response and the mixed reaction cones) a amplitudes,Max-R b amplitudes,cone-R (cone response) a wave amplitude,cone-R b amplitudes,30Hs blinking light reaction P1 wave amplitude decreased (F =3.716,6.524,3.825,4.59,7.52,P =0.03,0.00,0.03,0.04,0.00);PVEP of P100 latency (F =9.35,P =0.00),P100 amplitude was significantly lower (F =7.15,P =0.00);low altitude population centers retinal thickness normal and abnormal group Max-R (dark adaptation reaction was mixed reaction largest rod and cone cells) a amplitude value,Max-R b amplitudes,cone-R (cone response) a amplitudes,Cone-R b amplitudes,30Hs blinking light reaction P1 wave amplitude decreased (F =3.56,5.42,4.25,5.12,6.52,P =0.03,0.02,0.03,0.02,0.00);PVEP of P100 latency (F =2.19,P =0.10),P100 amplitude was significantly lower F =9.85,P =0.00);central retinal thickness normal high altitude group Compare Max-Ra amplitudes and reduced low altitude group FERG (F =1.796,P =0.08),Max-R b wave amplitude decrease F =3.114,P =0.03),Cone-Ra amplitude value decreased (F =3.758,P =0.04),Cone-R b wave amplitude decrease (F =3.714,P =0.03),30Hs scintillation light reaction P1 wave amplitude decrease (F =3.718,P =0.03);PVEP of P100 latency (F =2.11,P =0.10),P100 amplitude was significantly reduced (F =10.15,P =0.00).central retinal thickness abnormal high altitude and low altitude cluster group FERG Compare Max-R,a wave amplitude decrease is not obvious (F =2.792,P =0.06),Max-R b wave amplitude decrease (F =6.485,P =0.00),Cone-R a wave amplitude decrease (F =3.518,.P =0.03),Cone-R b wave amplitude decrease (F =3.724,P =0.03),30Hs scintillation light reaction P1 wave amplitude decreased (F=4.812,P =0.02);P100 latency changes PVEP not obvious (F =8.49,P =0.00),P100 wave amplitude value fell significantly (F =1.72,P =0.09).Conclusions After the Tibetan plateau residents and non-residents of tow-lying Han proliferative diabetic retinopathy retinal thickness changes in the eye center,cones function has a more significant damage,central retinal morphological changes accompanied by a significant change in macular function.

Objective To observe the effects of the hemodynamic of eye for axial length of non-proliferative diabetic retinopathy.Methods A prospective study.Patients with Diabetes and DR of hospitalized 248 cases (248 eyes) in Department of Ophthalmology and Endocrinology were included in the study.All patients underwent Fluorescence Fundus Angiography (FFA) and optical coherence tomography (OCT) examination.Patients were excluded with central retinal edema,hemorrhage,retinal exudates,and other diseases.Eye axial length was measured using type A ultrasonic diagnostic apparatus,and were divided into three groups:22-24 mm group (normal group),24-26 mm group (group axial length),26 mm or more groups (long axial group).Each group of patients underwent eye color Doppler flow imaging (CDFI) check indicators and FFA retinal vascular filling indicators,the indicators for comparison,the different hemodynamic parameters in patients with axial shaft length differences were observed.Results Normal axial group were compared with the axial extension,OA group axial length of PSV (crn/s) no significant change (F =1.265,P =0.20),CRA 's PSV (cm/s) lower (F =4.289,P =0.02),PCA's PSV (cm/s) higher (F =4.595,P =0.01),PI(F =4.258,4.682,4.596,P =0.02,0.01,0.01) and RI(F =4.196,4.658,3.652,P =0.02,0.01,0.03) was relatively low,differences were statistically significant (P ＜0.05).Normal group with long axial group,Long axial group OA,CRA and PCA of PSV (F =7.589,9.574,8.365,P =0.00,0.00,0.00) High;RI(F =11.982,13.584,10.983,P =0.00,0.00,0.00) PI(F =13.654,14.652,12.368,P =0.00,0.00,0.00) was low,the difference was statistically significant (P ＜0.005).Often long axial group compared with long axial group,long axial group of OA PSV (cm/s) faster,but no significant difference between the two (F =2.184,P =0.07),CRA's PSV (crn/s) lower (F =4.679,P =0.01),PCA of PSV (cm/s) higher (F =3.452,P =0.04),PI (F =3.886,3.952,12.362,P =0.03,0.03,0.00) and RI(F =4.686,4.359,4.685,P =0.01,0.02,0.01) was relatively low,the differences were statistically significant (P ＜0.05).Axial normal arm-retinal circulation time averaged 12.94 ± 0.46s,retinal AV fluorescence filling for an average of 13.56 ± 2.04s;Long axial group arm-retinal circulation time averaged 10.42 ± 0.51s,retinal AV fluorescence filling for an average of 9.15 ± 1.36s;Long axial group arm-retinal circulation time averaged 10.36 ± 0.64s,retinal AV fluorescence filling for an average of 6.36 ± 1.15s.Comparison of the three groups and the statistical treatment,arm-retinal circulation time was no significant difference (F =1.289,P =0.252);axial length of vascular filling time faster than the normal group,showed no significant difference (F =3.897,P =0.056);vascular filling time of Long axial group faster than the normal group(F =108.863,P =0.000),vascular filling time of long axial group faster than length axial group (F =175.516,P =0.000).Conclusions There is a clear correlation between axial length and ocular hemodynamics in patients with diabetic retinopathy.

Objective To observe the relationship between center retinal thickness and PVEP in non-proliferative diabetic retinopathy ( NPDR) .Methods Author retrospectively summarized the clinical data of NPDR patients diagnosed and treated in our hospital between January 2012 and March 2015.Patients were ruled out for other fundus conditions such as central retinal edema, hemorrhage, obviously ooze and other fundus lesions.Complete retinal OCT images, retinal elect-rodiagram and fundus angiography data of 120 cases (240 eyes) were collected.According to retinal thickness measured by OCT at different eccentricity (1 mm, 1~3 mm, and 3~6 mm) , patients were divided into normal, thin retina and thick retina groups.Relationships between retinal thickness and PVEP were studied.Results Retinal thickness was 276.4~304.9 um in normal group.PVEP P100 latency was delayed in all three NPDR groups, and the delay was more prominent in thin retina group than in two other groups ( F =13.68, 3.79;P =0.00, 0.04).Delay was longest in thin retina group.P100 amplitude significantly reduced in thin retina group and in thick retina group ( F =9.65, 19.36;P =0.00, 0.00) than in normal group.Lowest amplitude was found in thick retina group.Conclusion There was a clear relation-ship between PVEP and retinal thickness in NPDR patients.

目的 观察眼轴长度对非增生期糖尿病视网膜病变(diabetic retinopathy,DR)患者眼底血管充盈状态的影响.设计 前瞻性病例系列.研究对象 甘肃省第二人民医院眼科及内分泌科住院的无视网膜病变的糖尿病及非增生期DR患者254例(254眼).方法 所有患者均行荧光素眼底血管造影观察记录臂-视网膜循环时间、荧光动脉期、动静脉期及静脉期时间,记录视网膜荧光动脉期-静脉期(视网膜A-V)荧光充盈期平均时间.采用眼科A超测量眼轴长度,根据眼轴长度分为三组:正常组(22～24 mm),长眼轴组(＞24 mm且＜26 mm),超长眼轴组(≥26 mm).对比观察不同眼轴长度组眼底血管充盈状态异同.主要指标 臂-视网膜循环时间、视网膜A-V荧光充盈期平均时间及眼轴长度.结果 眼轴正常组、长眼轴组和超长眼轴组臂-视网膜循环时间平均分别为(10.94±0.46)s、(10.42±0.51)s和(10.36±0.64)s(F=1.289,P=0.252);视网膜A-V荧光充盈期平均分别为(13.56±2.04)s、(9.15±1.36)s和(6.36±.1.15)s(F=103.364,P=0.000);超长眼轴组与眼轴正常组比较眼底血管充盈时间变快(F=108.863,P=0.000),超长眼轴组与长眼轴组比较眼底血管充盈时间变快(F=175.516,P=0.000).结论 随着非增生期DR患者的眼轴长度增加眼底血管充盈时间缩短,血流充盈变快,从一个侧面反映了眼轴长度对非增生性DR患者视网膜血流动力学的影响.

AIM: To observe the effect of axial length on color Doppler hemodynamic of nonproliferative diabetic retinopathy (NPDR) eye. <br> METHODS: This is a prospective comparative case series study. The hospitalized patients with diabetic retinopathy from January 2012 to December 2013 in Department of Ophthalmology and Endocrinology of our hospital were included, those with central retinal significant edema, hemorrhage, exudation and significant other fundus lesions were excluded. According to ocular axial length measured by ophthalmologic A / B ultrasound scanner and axial length, the patients were divided into normal axial group (22 ~ <24mm), long axial group (24 ~<26mm) and super- long axial group (26mm or above). Color Doppler hemodynamic parameters of all patients were measured. Totally, 248 cases ( 248 eyes ) with complete research data were statistically analyzed and were observed the correlation between axial length and eye color Doppler hemodynamics. <br> RESULTS:Compared with normal axial group, OA PSV (cm/s) of long axial group did not change significantly (t=1.362, P=0.20), CRA PSV (cm/s) was high (t=-2.335, P=0.02), PCA PSV (cm/s) was higher (t=2. 756, P=0. 01), PI (t=-2. 371, -2. 585, -2. 67;P=0. 02, 0. 01, 0. 01) and RI (t= 2. 348, 2. 462, 2. 293;P=0. 02, 0. 01, 0. 03) is relatively lower, there were statistically significant differences ( P<0. 05). When compared with super-long axial group, ultra long shaft section OA(t=3. 290,P=0. 00) low, CRA and PCA PSV of normal axial group was higher (t=3. 290,-5.520, -4.900;P=0.00, 0.00, 0.00), PI (t=4.970,6.160, 5.990; P=0.00, 0.00, 0.00) and RI (t=-4.310, -5.230,-4. 390; P = 0. 00, 0. 00, 0. 00 ) was lower, there was statistically significant differences ( P < 0.005 ) . When compared with long axial group, OA in PSV ( cm/s ) of super-long axial group was more slower, but with no statistical significance (t=1. 967, P=0. 07), CRA PSV (cm/s) was lower (t=-2. 543, P=0. 01), PCA PSV (cm/s) was higher (t=-2.198, P=0.04), PI (t=-2.331,-2.135, -4.191;P=0.03, 0.03, 0. 00) and RI (t=2. 570, 2.360, 2. 490;P=0. 01, 0. 02, 0. 01 ) was relatively lower, there were significant differences (P<0. 05). <br> CONCLUSION: There is a clear correlation between axial length in diabetic retinopathy and ocular hemodynamics with color Doppler index.

目的 观察糖尿病视网膜病变眼轴轴长与中心视网膜厚度的相关性.方法 收集2012年1月至2013年5月入住我院眼科及内分泌科的糖尿病患者,经眼底荧光血管造影(fundus fluorescence angiography,FFA)确诊为糖尿病非增殖期的患者,采用眼科Axeg超测量眼轴长度,根据眼轴长度分为3组:22 ～ 24 mm组(正常组)60例(60眼)、＞24 ～ 26 mm组(长眼轴组)65例(65眼)、26 mm以上组(超长眼轴组)55例(55眼),对所有患者采用光学相干断层扫描(optical coherence tomography,OCT)进行中心视网膜厚度测量,对3组患者测量所得数据分析其差异性.结果 正常组中心视网膜厚度为(293.51±23.73) μm,长眼轴组中心视网膜厚度为(292.76±31.76) μm,超长眼轴组中心视网膜厚度为(277.89±37.82) μm.正常组与长眼轴组比较,中心视网膜厚度差异无统计学意义(t=0.191,P=0.849);正常组与超长眼轴组比较,超长眼轴组比正常组中心视网膜厚度显著变薄(t=-3.627,P=0.000);长眼轴组与超长眼轴组比较,超长眼轴组比长眼轴组中心视网膜厚度显著变薄(t=-3.644,P=0.000).结论 眼轴轴长与糖尿病视网膜病变中心视网膜厚度有明显的相关性,超长眼轴患者的中心视网膜厚度显著变薄.

为研究糖尿病视网膜病变(DR)患者中心视网膜厚度与眼部彩色多普勒血流动力学的相关性,我们对糖尿病无眼底病变及非增生期DR患者的中心视网膜厚度及眼部彩色多普勒血流动力学指标进行测量,现将结果报告如下. 一、资料与方法 (一)研究对象及分组 2012年1-12月入住甘肃省第二人民医院眼科及内分泌科的糖尿病患者527例,经荧光素眼底血管造影(FFA)确诊为糖尿病无眼底病变及非增生期DR患者248例248眼.入选患者采用蔡司Cirrus 400相干光断层扫描仪(OCT)测量黄斑中心区1-6 mm直径范围的中心视网膜神经上皮层厚度并将此范围界定为中心视网膜.依据黄斑及周围视网膜正常厚度参考值确定正常中心视网膜厚度为216.4～304.5 μm[1].

OBJECTIVE To observe the effect of Rong Mai San on the anteriorischemicoptico-neuropaty of the eye PRVEP. METHODS All of 58 anteriorischemicoptico-neuropaty inpatients were collected which from May 2010 to Oct 2013. Random distrubuted into two groups, including control group 30 and treatment group 28. Treatment group was administrated conventional therapy and oral Rong Mai San, and observed the change of PRVEP. Analysis and comparison effect of treatment in two groups. RESULTS Incubation period and amplitude of P100 no significant changes between two groups before treatment. After treatment, in control group, P100 Incubation period average,(107.40±1.45)ms,P100 Amplitude(3.34±0.11)μV; in treatment group, P100 Incubation period average(92.60±1.97)ms, P100 Amplitude(3.74±0.18)μV. Compared with two groups, the difference was statistically significant(P0.05). Difference between the control group before and after treatment: P100 Incubation period(8.39±0.89)ms, P100 amplitude(0.22±0.02)μV, the difference before and after the treatment group: P100 Incubation period(21.95±1.30)ms, P100 amplitude(0.58±0.03)μV. Compared with two groups, the difference was statistically significant(P0.05). CONCLUSION The eye PRVEP of anteriorischemicoptico-neuropaty is significantly improved by Rong Mai San treatment.

目的了解兰州市区小学及中学生的弱视发病情况，分析弱视的发病原因及分布情况。方法选择兰州市区5所小学及5所中学的初中生共计12361名进行视力普查，对矫正视力达不到0.9者进行验光矫正，对异常视力者进行视力损害原因分析，确定弱视发病者并分析发病原因。结果兰州市区12361名小学及中学生弱视发病人数为445人（512眼），发病率为3.6%，引起弱视的主要发病原因为屈光不正227例，占51.01%；斜视89例，占20.00%；屈光参差64例，占14.39%；形觉剥夺34例，占7.64%；其它31例，占6.96%。结论兰州市区的弱视发病率较全国平水平偏高，屈光不正及斜视是弱视的主要原因。

目的 评估泪小管皮下结扎术治疗泪液缺乏性干眼的临床可行性.方法 前瞻性研究.采用泪小管皮下结扎术治疗经药物治疗效果不传佳的泪液缺乏性干眼患者16例(29只眼),分别于治疗前及治疗后1个月、3个月进行眼表疾病指数(OSDI)评分、泪膜破裂时间(BUT)及基础泪液分泌试验(SIT)以观察临床疗效,观察泪小管皮下结扎术术区外观形态、缝线稳定性、缝线组织兼容性以及泪小管阻塞效果以观察该手术的临床可行性.结果 术后16例(29只眼)术区无明显的畸形,下睑形态无改变,2例患者于术后2~3周线节外露,1例患者于术后1周线结部位红肿,术后1周内所有患者泪小管阻塞效果确切,留线13例患者(26只眼)1~3个月泪小管术区外观形态、缝线稳定性、缝线组织兼容性以及泪小管阻塞效果均好,手术成功率89.66%(χ2=94.32 P= 0.005);治疗前、治疗后1个月、治疗后3个月患者OSDI平均值分别为35.32±2.41、19.86±8.07及17.97±7.93,BUT平均值分别为(3.71±0.66)s、(6.02±2.34)s及(7.56±2.33)s,SIT平均值分别为(4.03±0.75)mm、(6.60±2.16)mm及(6.43±2.11)mm,3项评价指标治疗前后差异均有统计学意义(P＜0.01).治疗后3个月,11例23只眼干眼症状明显缓解,治疗有效率88.46%(χ2=85.23,86.15 P＜0.05 ).结论 泪小管皮下结扎术治疗泪液缺乏性干眼简单经济、实用有效、安全易行.

Objective To observe the effect of lowering intraocular pressure(IOP) treatment on ocular hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).Methods A total of 68 patients with NAION (68 eyes) were enrolled in this study.The patients were randomly divided into treatment group (38 eyes of 38 patients) and control group (30 eyes of 30 patients).All the patients were received methylprednisolone pulse therapy (200 mg,three days),vasodilator therapy with intravenous infusion of Xueshuantong solution (300 mg),optic nerve nutritional therapy with mouse nerve growth factor (30 μg) and acupoint injection in temporal with compound anisodine (2 ml).The total course was 10 days.The patients of treatment group received IOP lowering treatment to reduce the IOP to ≥ 8 mm Hg (1 mm Hg=0.133 kPa) or in a 30％ reduction.The patients of control group received no IOP lowering treatment.The peak systolic velocity (PSV),pulsatility index (PI) and resistance index (RI) of ophthalmic artery (OA),central retinal artery (CRA) and short posterior ciliary arteries (PCA) before and after treatment were comparatively analyzed by color doppler flow imaging.Results The differences of PSV (t=1.023,1.145,0.569),PI (t=0.679,0.956,1.634) and RI (t=0.816,1.657,0.998) of OA,CRA and PCA before treatment in treatment group and control group were not statistically significant (P＞ 0.05).Compared with before treatment,PSV (t=3.150,7.650,3.520) and PI (t=2.420,5.430,7.650) of OA,CRA and PCA increased obviously (P＜0.05),RI of OA,CRA and PCA decreased obviously (t=5.320,9.640,18.360; P＜0.05) after treatment in treatment group.In control group,the differences of PSV (t=2.090,-2.550,-2.100) and PI (t=-2.310,-2.230,-4.490) of OA,CRA and PCA between before and after treatment were not statistically significant (P＞0.05) ; but the differences of RI of OA,CRA and PCA between before and after treatment was statistically significant (t=2.970,2.160,2.690μ P＜0.05).Compared with control group,PSV (t=2.632,2.135,5.364) and PI (t=3.251,2.432,4.243) of OA,CRA and PCA increased obviously (P＜0.05),RI of OA,CRA and PCA decreased obviously (t=3.664,2.938,4.324; P＜0.05) after treatment in treatment group.Conclusion Lowering intraocular pressure treatment can improve the ocular hemodynamics in NAION patients.

Objective To study the relationship between central retinal thickness and retinal vascular filling state of patients with non-proliferative diabetic retinopathy (NPDR).Methods A total of 248 diabetic patients without retinopathy or with NPDR in the hospital were enrolled in the study.Only the right eye of these patients were examined by optical coherence tomography (OCT),fundus fluorescein angiography (FFA),color Doppler flow imaging (CDFI).Patients with central retinal edema,hemorrhage and exudation were excluded from this study.Central retinal thickness was measured by OCT at the points of 1 mm,1 to 3 mm,and 3 to 6 mm from the fovea.The patients were divided into retinal thickness normal,thinning and thickening groups according to their central retinal thickness.The normal range of central retinal thickness was defined as 216.4-304.9 μm in this study.The arm retinal circulation time and retinal arterial phase and venous phase (A-V) fluorescence filling time were recorded by FFA examination.The peak systolic velocity (PSV),pulsatility index (PI) and resistance index (RI) of ophthalmic artery (OA),central retinal artery (CRA) and posterior ciliary artery (PCA) were measured by CDFI examination.The retinal fundus vascular filling state and ocular hemodynamic indexes were compared between different groups.Results The arm retinal circulation time of retinal thickness normal,thinning,thickening groups was (10.42±0.51),(10.36±0.64),(12.94±0.46) seconds respectively; the retinal A-V fluorescence filling time was (9.15±1.36),(6.36±1.15),(13.56±2.04) seconds.The difference of the arm retinal circulation time was statistically significant between the thickening and normal groups (t=1.93,P=0.04),and between the thickening and thinning groups (t=4.49,P=0.00).The retinal A-V fluorescence filling time was statistically significant between the thinning and normal groups (t=2.13,P=0.03),and between the thickening and normal groups (t=2.49,P=0.02),and between the thickening and thinning groups (t=5.38,P=0.00).The difference of PSV (t=3.290,-5.520,-4.900),PI (t=-4.310,-5.230,-4.390) and RI (t=4.970,6.160,5.990) of OA,CRA and PCA was statistically significant between the thickening and thinning groups (P＜0.05).Conclusion Central retinal thickness can affect the retinal vascular filling state of diabetic patients without retinopathy or with NPDR.

Objective Explore the limbus vascular network to cut the safety and efficacy of intraoperative mitomycin treatment of corneal neovascularization.Methods 35 cases(36 eyes) of trauma and other causes of corneal neovascularization by rhizotomy combined with mitomycin treatment.Combined corneal ulcer 6,merger leucoma 3;neovascularization involving the central corneal 6,next to the central area 8,the peripheral area 12,the limbal area 10.All patients were followed up 6 months to observe the eye symptoms,complications and visual acuity.Results Decrease in the number of the original neovascularization,corneal edema,turbidity reduced,inflammation control,corneal transparency improved.6 months after surgery,neovascularization completely disappeared in 15 eyes(41.6%);recurrence in 5eyes(13.8%).Conclusion The limbal vascular network cut with mitomycin treatment of corneal neovascularization,no significant side effects,can reduce the acute phase of the inflammatory response,and shorten the course.

Objective To study the influence of intraocular pressure(IOP)-lowering treatment on visual evoked potential(VEP) in eyes with anterior ischemic optic neuropathy(AION).Design Retrospective comparative case series.Participants From 2008 to 2011,a total of 68 cases of AION in the Second People's Hospital of Gansu were enrolled.The participants were randomly divided into control group(non-IOP-intervention) with a total of 30 cases(30 eyes) and lowering IOP group(IOP intervention) with a total of 38 cases(38 eyes).Methods The patients in IOP intervention group underwent an IOP lowering treatments to reduce IOP≥8 mm Hg or lower the IOP≥30%.All the eyes underwent pattern visual evoked potential(PVEP) test.The PVEP characteristies were analyzed both groups before and after treatment.Main Outcome Measures P100 latency,P100 amplitude of the PVEP.Results P100 latency in the intervention group(93.82±1.97 ms) was significantly shorter than non-IOP intervention group(112.38±1.45 ms)(t=46.36,P<0.001);P100 amplitude in the intervention group(3.64±0.23 μv) was significantly higher than non-IOP intervention group(3.14±0.23 μv)(t= 8.76,P<0.001).Conclusion Intraocular pressure-lowering treatment in AION eyes was benifitrial to PVEP.