目的:评价司库奇尤单抗治疗红皮病型银屑病的临床疗效及安全性.方法:选取红皮病型银屑病患者6例,给予司库奇尤单抗皮下注射,300 mg/次,前4周每周一次,之后每4周一次,并分别于治疗前、4周后、12周后记录患者的皮损面积和严重度指数(PASI)、皮肤病生活质量指数(DLQI)评分.结果:治疗前,患者的PASI评分均值为(24.00±4.32)分.治疗4周后,患者的PASI评分均值为(7.17±2.89)分,其中50％患者的PASI评分改善率达75％.治疗12周后,患者的PASI评分均值为(0.55±0.69)分,所有患者的PASI评分改善率均达90％,其中3名患者(50％)的PASI评分改善率达100％.治疗前,患者的DLQI评分均值为(20.50±4.51)分.治疗4周后,患者的DLQI评分均值为(14.17±3.77)分,DLQI评分中位数下降8.5分.治疗12周后,患者的DLQI评分均值为(1.83±1.94)分,DLQI评分中位数下降20.5分.所有患者在治疗期间均未出现严重的药物不良反应.结论:司库奇尤单抗治疗红皮病型银屑病的疗效较为显著,不良反应少.

陶迪生对白癜风的诊治颇有特色,临床上将其分为6种证型,即血虚风袭证、脾虚风袭证、肾虚风袭证、肝郁风袭证、血瘀风袭证及风湿热证.此诊治思路实用性强且有助于疗效的提高、病程的缩短.现简要介绍陶氏治疗白癜风的临床经验.

李大姐人值中年,身体别无大恙,唯一烦心的是,近3年来一到梅雨季节,脚趾间就出现红肿、渗液、瘙痒.由于秋冬季节会自然减轻,未予特别重视.可今年情况与以往不同,除足趾间糜烂、渗液外,足背还严重肿胀,影响步行,全身起红斑、丘疹、瘙痒难耐,无奈只得去医院诊治.经医生取皮屑在显微镜下检查,发现了致病的罪魁祸首——真菌,李大姐所患皮肤病为"糜烂型足癣并发癣菌疹".

OBJECTIVE:To elucidate the pharmacological mechanisms of Qubi Formula (QBF), a traditional Chinese medicine (TCM) formula which has been demonstrated as an effective therapy for psoriasis in China.METHODS:The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, BATMAN-TCM database, and literature search were used to excavate the pharmacologically active ingredients of QBF and to predict the potential targets. Psoriasis-related targets were obtained from Therapeutic Target Database (TTD), DrugBank database (DBD), MalaCards database, and DisGeNET database. Then, we established the network concerning the interactions of potential targets of QBF with well-known psoriasis-related targets by using protein-protein interaction (PPI) data in String database. Afterwards, topological parameters (including DNMC, Degree, Closeness, and Betweenness) were calculated to excavate the core targets of Qubi Formula in treating psoriasis (main targets in the PPI network). Cytoscape was used to construct the ingredients-targets core network for Qubi Formula in treating psoriasis, and ClueGO was used to perform GO-BP and KEGG pathway enrichment analysis on these core targets.RESULTS:The ingredient-target-disease core network of QBF in treating psoriasis was screened to contain 175 active ingredients, which corresponded to 27 core targets. Additionally, enrichment analysis suggested that targets of QBF in treating psoriasis were mainly clustered into multiple biological processes (associated with nuclear translocation of proteins, cellular response to multiple stimuli (immunoinflammatory factors, oxidative stress, and nutrient substance), lymphocyte activation, regulation of cyclase activity, cell-cell adhesion, and cell death) and related pathways (VEGF, JAK-STAT, TLRs, NF-κB, and lymphocyte differentiation-related pathways), indicating the underlying mechanisms of QBF on psoriasis.CONCLUSION:In this work, we have successfully illuminated that Qubi Formula could relieve a wide variety of pathological factors (such as inflammatory infiltration and abnormal angiogenesis) of psoriasis in a "multicompound, multitarget, and multipathway" manner by using network pharmacology. Moreover, our present outcomes might shed light on the further clinical application of QBF on psoriasis treatment.

Objective:To observe the effect of acne-eliminating cream on acne in a rabbit ear acne model.Methods:Thirty New Zealand rabbits of both genders were divided into normal control group, acne model group, high and low dose of acne-eliminating cream group, tretinoin cream group. Except 3 rabbits in normal control group, ears of the rest rabbits were treated topically with coal tar for 2 weeks to establish acne model. Afterwards vehicle, acne cream (high and low dose), and 0.1 ％ tretinoin cream were applied to respective group of rabbit ears daily for 3 weeks. Ear samples were taken 24 hours after the last topical treatment, followed by fixation in 10％ formaldehyde and hematoxylin-eosin staining. Histopathological changes were assessed and photographed under a microscope.Results:In comparison to untreated acne ears, high dose of acne-eliminating cream markedly reduced the intensity of ear reactions to coal tar (t=2.62, P<0.05). Moreover, high dose of acne-eliminating cream significantly reduced epidermal thickness, dilation of follicular orifice, perifollicular hyperkeratosis and inflammatory cells (χ2=4.00, P<0.05 vs. untreated acne ears). However, low-dose of acne-eliminating cream did not dramatically alleviate acne in this model (χ2=1.09, P>0.05 vs. untreated acne ears). High dose of acne-eliminating cream and tretinoin cream exerted comparable efficacy in reduction of intensity of ear reactions to coal tar and improvements in histopathology (t=0.06, P>0.05 for reduction of intensity;χ2=0.34, P>0.05 for histopathology).Conclusion:High dose of acne-eliminating cream can significantly improve the acne in coal tar-induced rabbit ear acne model.

介绍陶迪生教授辨治银屑病的经验.陶教授认为银屑病病因为风、热、燥、瘀,病机初期为肺燥阴虚,继之可致肝肾阴虚;病情进一步发展则燥热炽盛,热入营血;后期则邪热久留,阴虚血燥;如热邪煎熬,热结血瘀,则斑块顽固难消.临证将该病分为卫表燥热证、肝郁化火证、血热证、肝肾阴虚证、血瘀证、血燥证、湿热蕴结证,并分别采用与之相对应的治法和方药.验之临床多年,疗效显著.

目的 观察热毒宁注射液联合窄谱紫外线治疗寻常型银屑病的临床疗效.方法 治疗组22例采用热毒宁注射液联合NB-UVB照射,对照1组22例采用复方甘草酸苷注射液联合NB-UVB照射,对照2组22例单独照射NB-UVB,三组分别于治疗前、治疗3周后记录PASI积分,计算疗效指数.结果 治疗组治疗前后PASI评分比较,差异有显著性(P＜0.05),治疗后治疗组与对照1组评分比较,差异有显著性(P＜0.05),治疗后治疗组与对照2组评分比较,差异有显著性(P＜0.05).治疗组、对照1组、对照2组有效率分别为90.91％、72.73％、54.55％,总显效率分别为59.09％、27.27％、18.19％,治疗组治疗效果明显优于对照组.结论 热毒宁注射液联合窄谱紫外线治疗寻常型银屑病疗效显著.

目的 观察蜂针疗法对寻常性银屑病患者Th17相关因子IL-17,IL-22,IL-23水平的影响.方法 入选的30例寻常性银屑病(稳定期)患者,均为蜂针试验阴性或弱阳性者.选取10日龄以上意大利蜂,用蜂量从2只开始,每1周治疗1次,4周为1个疗程,共治疗2个疗程.治疗前后采用双抗体夹心ELISA法,检测外周血Th17相关因子IL-17,IL-22,IL-23的水平.同时选择30例健康人为对照组.结果 蜂针疗法后,银屑病患者外周血中IL-17,IL-23水平较治疗前有所下降,差异有统计学意义(P均＜0.05);IL-22水平较治疗前有所下降,差异无统计学意义(P＞0.05).蜂疗结束后,有5例患者出现新的银屑病皮疹,皮疹主要分布在蜂疗外区域,占临床总有效患者的17.24％.结论 蜂针疗法治疗寻常性银屑病效果明显,能有效改善银屑病皮损,蜂毒能有效降低银屑病患者血液中IL-17和IL-23的水平,通过降低IL-17的水平,促进皮损的消退.蜂针疗法在治疗寻常性银屑病方面,疗效显著,副作用小,复发率低,值得临床上推广使用.

Objective To observe the efficacy of 5-ALA-PDT combined with externalwashing with Traditional Chinese Medicine in treatment of Facial Multiple Verruca Plana. Methods The patients were randomly divided into group A (23 cases) and group B (23 cases) and group C (23 cases). The patients of group A were treated by ALA-PDT every 10 days for four times in total. The patients of group B were treated by external washing with Traditional Chinese Medicine. The patients of group C were treated by ALA-PDT combined with external washing with Traditional Chinese Medicine. Each group were treated for 40 days. Results The obviously effective rates of group C was 73.91%,much higher than group A (43.48%)and group B(39.13%).There was a signiifcant difference between group C with A and B(P<0.05). There was no signiifcant difference on the effective rates of group A and B (P>0.05). The total effective rates of group C was 91.3%,much higher than group A (78.26%)and group B(69.57%),but with no signiifcant different(P>0.05). Conclusion The method of ALA-PDT therapy combined with external washing with Traditional Chinese Medicine in treatment of Facial Multiple Verruca Plana is safe and effective,and is better than using respectively.

目的:优选痤疮消凝胶的提取工艺,为该制剂的临床应用提供参考.方法:以大黄游离总蒽醌、栀子苷、咖啡酸含量的综合评分为指标,采用均匀设计法考察乙醇体积分数、乙醇用量、提取时间和提取次数对提取工艺的影响.采用HPLC测定大黄游离总蒽醌、栀子苷、咖啡酸含量,流动相分别为甲醇-0.1％磷酸溶液(85: 15),甲醇-水(23:77),乙腈-0.1％磷酸溶液(10: 90),检测波长依次为254,238,323 nm.结果:最佳提取工艺参数为加12倍量80％乙醇提取3次,每次1h.大黄游离总蒽醌、栀子苷、咖啡酸质量浓度分别为1 260.33,1 597.56,32.19 mg·L-1.结论:优选的痤疮消凝胶提取工艺合理可行、重复性好,为该制剂生产工艺参数的确定提供实验依据.

目的 本文旨在探讨白癜风发病的关键病机,以期为白癜风的中医治疗提供指导.方法 从古代医籍对白癜风的病机论述、"补血祛风"中药的现代药理研究成果以及"补血祛风"中药治疗白癜风的临床疗效等方面进行分析探讨.结果 "血虚风袭"可致皮肤变白,用"补血祛风"药治疗白癜风具有较好的临床疗效.结论 "血虚风袭"是导致白癜风发病的关键病机.

我科自2012年8月-2013年2月采用5-氨基酮戊酸光动力疗法治疗多发性扁平疣取得较好疗效,现报道如下. 1资料和方法 1.1 临床资料20例扁平疣患者均为门诊患者,其中男性6例,女性14例;年龄范围(19 ～45)岁,平均年龄(28.63±5.73)岁;20例扁平疣患者均符合《杨国亮皮肤病学》的诊断标准[1]],皮损数量均超过30个;其中病程超过6个月,近4周未经过任何治疗的15例,病程未超过6个月,未经过任何治疗的5例;皮损位于颜面部18例,手背部1例,前臂1例.所有患者均排除合并严重心、肺、肾、消化道及内分泌等疾病、排除妊娠及哺乳期、排除疤痕体质.

目的 观察5-氨基酮戊酸光动力(5-ALA-PDT)联合丹参酮治疗中重度痤疮的效果.方法 将89例Ⅱ～Ⅳ度中重度痤疮患者随机分为治疗组与对照组,治疗组45例,予以5-氨基酮戊酸光动力联合丹参酮胶囊治疗;对照组44例,予以外涂过氧化苯甲酰凝胶联合丹参酮胶囊治疗,40 d后进行疗效评定与对比.结果 治疗组痊愈率62.22％,总有效率84.44％,与对照组(痊愈率和总有效率分别为40.91％、65.91％)比较,差异均有统计学意义(两者的统计结果分别为x2=4.05,P＜0.05;x2=4.11,P＜0.05).结论 5-氨基酮戊酸光动力联合丹参酮治疗中重度痤疮有较好的临床疗效,且操作简便,不良反应少.

痤疮是一种毛囊皮脂腺慢性炎症性皮肤病.该病多发于青春期,且发病率高,炎症消退很慢,中重度痤疮治疗不及时或治疗不当往往容易形成瘢痕,对患者形象和社交造成较大影响.以往,痤疮的治疗以内服和外用药物为主.近年,光动力疗法治疗痤疮取得了较大进展,为中重度痤疮的治疗又提供了一种药物治疗以外的较好选择.2011年1月-2012年12月我科用光动力疗法治疗中重度痤疮180例取得了很好疗效.现报道如下.

雄激素性脱发(AGA)旧称"脂溢性脱发".该病临床发病率高,迄今为止医学界尚缺少特别有效而又安全的治疗药物和方法.2008年6月至2010年12月我们用自拟生发洗方治疗该病取得了满意疗效,现报道如下.

Based on the characteristics of the onset age of acne,relationship of both inter-promotion and inter-restraint among the five elements between the liver and the lung,route of main and collateral channels,relationship among emotions,menstruation and acne,and clinical effects,etc.this article emphasized treating acne from the liver theory and discussed its theoritical and clinical evidence.According to this artical,"the liver fire attacking the lung" was the important pathogenesis of the occurrence of acne,"Eliminating the liver fire" was the important method of treating acne.

Objective:To observe the clinical efficacy of No.1 Quyou washing formula on preventing the recurrence of genital warts.Methods:71 cases of genital warts patients were randomly divided into treatment group and control group.The treatment group was given No.1 Quyou washing formula after laser therapy twice a day,15 minutes for each time;the control group was given Waicha recombinant human interferon alpha-2b cream after laser therapy twice a day.Both groups were treated 12 weeks for a course,and the efficacy evaluation was made.During treatment,the detailed records of wart recurrence and adverse reactions were observed every two weeks.Results:The cure rate and recurrence rate of 12 weeks after the two sets of laser therapy had significant difference(P<0.05).Conclusion:No.1 Quyou washing formula is effective on preventing the recurrence of genital warts and superior to recombinant human interferon alpha-2b cream.

肤宁冲剂为江苏省中西医结合医院皮肤科经验方,用于治疗丘疹性荨麻疹疗效较好.我们于2005年1月至2007年6月对肤宁冲剂免煎配方颗粒与其饮片汤剂采取多中心、随机、双盲对照的试验方案进行了临床疗效对比及安全性观察,现总结如下.