目的 探讨股骨近端防旋髓内钉(PFNA)治疗老年股骨粗隆间骨折术后功能康复的影响因素.方法 回顾性分析2016年1月至2021年10月于北京中医药大学第三附属医院接受PFNA手术治疗的220例老年股骨粗隆间骨折患者的临床资料.根据术后半年髋关节Harris评分将患者进行分组,其中评分≥80分为疗效优良组,评分＜80分为疗效一般组.对两组性别、年龄、骨折分型、手术时间、手术时机、体重指数、美国麻醉医师协会(ASA)分级进行单因素分析,并对有统计学意义的指标进行多因素回归分析,以明确PFNA治疗老年股骨粗隆间骨折术后功能康复的影响因素.结果 单因素分析结果显示,两组性别、手术时间、体重指数比较,差异无统计学意义(P＞0.05),两组年龄、骨折分型、手术时机、ASA分级比较,差异有统计学意义(P＜0.05).logistic多元线性回归分析结果显示,年龄、手术时机是PFNA治疗老年股骨粗隆间骨折术后功能康复的独立影响因素(P＜0.05).结论 高龄及各种原因延迟手术都将影响PFNA治疗老年股骨粗隆间骨折术后功能康复效果,因此对于上述患者应早期创造条件行手术治疗以提高临床效果.

目的:分析膝骨关节炎患者中医证候类型,探寻不同证候膝骨关节炎患者的临床特征.方法:从我院门诊系统中以"膝骨关节病""膝骨关节炎"和"膝痹"为关键词进行检索,并提取28 763例患者的基本信息、就诊日期以及诊断信息,对上述信息进行整理后,按照节气进行统计.结果:患者平均年龄是(64.24±12.60)岁,男女患者比例为1 ∶ 2.4,气滞血瘀证发病率为64.98％,肝肾亏虚证发病率为37.30％,寒湿痹阻证发病率为21.33％,气血虚弱证发病率为1.22％,湿热痹阻证发病率为0.24％;男性在立春和雨水时寒湿痹阻证发病率高,在清明至芒种时段湿热痹阻证发病率与女性相当,其余时段男性发病率略高于女性,在秋分时气血虚弱证发病率高;女性在惊蛰和春分时寒湿痹阻证和气滞血瘀证发病率高,在立春至春分时肝肾亏虚证发病率高.结论:膝骨关节炎是中老年人常见疾病,女性发病率高于男性,不同证型与节气有相关性,男性在立春和雨水时节应注意预防风寒湿邪,在夏季应预防湿热,临近秋分时节应提前补益气血;女性在平时更应注重补益肝肾,在惊蛰和春分时应预防风寒湿邪、调理气血.

目的:观察桃红四物汤十五苓散口服治疗踝关节骨折术后肿胀的临床疗效.方法:回顾性分析2018年1月至2019年1月采用桃红四物汤十五苓散口服治疗25例踝关节骨折术后患者病例资料,男13例,女12例;年龄28?65岁,平均(46.0士3.5)岁.全部行切开复位内固定术,术后第1?7天口服桃红四物汤十五苓散,观察术后第1,3,5,7天患肢的肿胀程度及疼痛减轻程度,并评定临床疗效.结果:肿胀值术后第1,3,5,7天分别为(4.89士1.09)cm,(3.82士0.64)cm,(2.93士0.42)cm,(1.65士0.46)cm,治疗前后差异有统计学意义(P＜0.05),说明患肢的肿胀程度明显减轻.疼痛视觉模拟评分(VAS):术后第1,3,5,7天分别为7.80士0.84,5.41士0.83,3.68士0.54,1.45±0.73,治疗前后差异有统计学意义(P＜0.05),说明患肢的疼痛程度明显减轻.临床疗效:显效18例,有效3例,无效4例,总有效率为84.00％.结论:桃红四物汤十五苓散口服能够减轻踝关节骨折术后肿胀及疼痛,有利于早期康复,值得推广应用.

目的 观察生肌玉红膏治疗跟骨骨折术后切口愈合不良的临床疗效.方法 选取2018年12月-2020年5月北京中医药大学第三附属医院及中国人民解放军陆军第八十集团军医院收治的72例跟骨骨折术后切口愈合不良患者,采用随机数字法分为试验组36例和对照组36例,试验组采用生肌玉红膏换药,对照组采用凡士林换药,2组均治疗4周.观察2组治疗不同时间点创面视觉模拟疼痛(VAS)评分、创面面积、创面愈合时间及治疗4周后创面愈合率、临床疗效、不良反应发生情况.结果 对照组脱落1例;对照组治疗后VAS评分均随治疗时间延长逐渐提高(P均＜0.05),试验组随治疗时间延长,VAS评分先增高,而后降低,试验组换药第7次VAS评分明显高于对照组(P＜0.05),治疗第14次时VAS评分明显低于对照组(P＜0.05).2组创面面积均随治疗时间延长逐渐缩小(P均＜0.05),且试验组各时间点创面面积均小于同期对照组(P均＜0.05);治疗4周后试验组的创面愈合率和总有效率均显著高于对照组(P均＜0.05).2组均未发现不良反应.结论 生肌玉红膏能够增加跟骨骨折术后切口愈合不良患者对疼痛的敏感度,促进创面早期愈合,愈合率高,且愈合时间明显缩短.

目的:基于网络药理学预测金匮肾气丸治疗骨质疏松症的作用机制.方法:通过中药系统药理学数据库与分析平台(TCMSP)、中药分子机制综合数据库(TCMID)、中药分子机制生物信息学分析工具(BATMAN-TCM)等数据库检索金匮肾气丸药物成分及成分相关靶点;以"Osteoporosis"为关键词在人类基因数据库(GeneCards)、在线人类孟德尔遗传数据库(OMIM)、DrugBank等数据库检索骨质疏松症疾病相关靶点;制作韦恩图,获取药物-疾病交集靶点;利用String数据库、Cytoscape 3.6.1软件构建药物-疾病交集靶点蛋白互作网络及药物-成分-疾病-靶点网络;通过DAVID数据库对药物-疾病交集靶点进行基因本体(GO)、京都基因和基因组百科全书(KEGG)富集分析,并将富集结果可视化.结果:共获得金匮肾气丸药物成分118个,包括槲皮素、山柰酚、大黄素等;有效成分相关靶点202个,疾病相关靶点1856个,药物-疾病交集靶点87个,包括前列腺素内过氧化物合酶2(PTGS2)、转录因子(JUN)、胞间黏附分子1(ICAM1)等;GO富集分析功能条目376条,其中生物过程(BP)290条,细胞组分(CC)28条,分子功能(MF)58条,包括RNA聚合酶Ⅱ启动子的转录正调控、类固醇激素受体活性等;KEGG信号通路共90条,包括类风湿性关节炎信号通路、破骨细胞分化信号通路、催乳激素信号通路等.结论:金匮肾气丸通过槲皮素、山柰酚、大黄素、薯蓣皂苷元、β-谷甾醇等有效成分作用于PTGS2、JUN、ICAM1、白细胞介素-1β(IL-1β)、基质金属蛋白酶9(MMP9)等关键靶点通过抗氧化、抑制炎症反应、促进成骨细胞增殖分化、抑制破骨细胞骨吸收等作用机制达到治疗OP的作用.

目的 基于网络药理学预测独活寄生汤治疗强直性脊柱炎的作用机制.方法 通过中药系统药理学数据库与分析平台(TCMSP)、中药分子机制综合数据库(TCMID)、中药分子机制生物信息学分析工具(BATMAN-TCM)等数据库搜索独活寄生汤中各药物成分及其相关靶点,以Ankylosing spondylitis为关键词在DrugBank、GeneCards、OMIM、TTD等数据库搜索强直性脊柱炎的疾病相关靶点,通过制作韦恩图,获取药物-疾病交集靶点,利用String数据库、Cytoscape 3.6.1软件构建药物-疾病交集靶点蛋白互作网络、药物-成分-疾病-靶点网络,最后通过DAVID数据库对药物-疾病交集靶点进行基因本体(GO)功能富集分析、京都基因与基因组百科全书(KEGG)通路富集分析,并将富集结果可视化.结果 通过TCMSP、TCMID、BATMAN-TCM三个数据库共获得独活寄生汤药物化学成分264个,包括槲皮素、山柰酚、柚皮素、汉黄芩素、黄芩素等;有效成分与强直性脊柱炎共同作用靶点129个,包括肿瘤坏死因子(TNF)、白细胞介素6(IL6)、脂多糖受体(CD14)、前列腺素内过氧化物合酶1(PTGS1)等;GO富集分析功能条目547条,其中生物过程(BP)435条,细胞组分(CC)40条,分子功能(MF)72条,包括细胞对脂多糖的反应、类固醇激素受体活性等;KEGG信号通路共101条,主要包括核因子κB(NF-kB)信号通路、核苷酸结合寡聚域(NOD)样受体信号通路、低氧诱导因子-1(HIF-1)信号通路、催乳素信号通路等.结论 独活寄生汤治疗强直性脊柱炎主要是通过槲皮素、山柰酚、柚皮素、汉黄芩素、黄芩素等活性成分作用于信号转导和转录激活因子3(STAT3)、白细胞介素1β (IL1B)、血管内皮生长因子(VEGFA)、白细胞介素10 (IL10)等关键靶点基因从而调节多条生物学功能与信号通路,最终达到治疗强直性脊柱炎作用.

由于受到医疗条件限制,过去许多髌骨不稳(Patellofemoral Instability,PI)的患者未能被及时确诊.随着X线的普及使用,现代解剖学及生物力学的发展,该病逐渐被临床医师认识而被诊断[1].髌骨不稳主要发生于20～30岁年轻人,发病率为13％～27％,而女性的发病率是男性的2～4倍,运动员的发病率可高达40％[15].虽然多种原因都可以导致髌骨不稳,但是目前认为髌股关节运动轨迹、对应关系失常,是发生髌骨不稳的最主要原因[6-7].髌骨不稳的患者在屈膝运动过程中,由于髌股韧带内、外侧肌力不平衡,导致膝关节周围疼痛,甚至可以出现膝关节不稳、打软腿[3],患者通常伴有髂胫束紧张而影响蹲起活动[6].由于髌骨倾斜度增加,髌股关节内侧接触面积减小,应力主要集中于外侧髌股关节面,导致髌股关节软骨退变,最终发生膝骨关节病[8-10].

目的:基于网络药理学探讨补阳还五汤治疗强直性脊柱炎的作用机制.方法:通过中药系统药理学数据库与分析平台(traditional chinese medicine systems pharmacology database and analysis platform,TCMSP)、中药分子机制综合数据库(traditional Chinese medicine integrated database,TCMID)、中药分子机制生物信息学分析工具(bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine,BATMAN-TCM)等数据库搜索补阳还五汤药物成分及其相关靶点;以"Ankylosing spondylitis"为关键词在DrugBank、人类基因数据库(GeneCards)、在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)、治疗靶标数据库(therapeutic target database,TTD)等数据库搜索强直性脊柱炎的相关靶点;通过制作韦恩图,获取补阳还五汤与强直性脊柱炎的交集靶点,利用String数据库、Cytoscape 3.6.1软件构建药物疾病共同靶点蛋白互作网络、药物-成分-疾病-靶点网络;最后通过DAVID数据库(The database for annotation,visu-alization and integrated discovery)对共同靶点进行基因本体(gene ontology,GO)、京都基因和基因组百科全书(kyoto ency-clopedia of genes and genomes,KEGG)富集分析,并将富集结果可视化.结果:通过TCMSP、TCMID、BATMAN-TCM 3个数据库共获得补阳还五汤药物化学成分106个,包括槲皮素、山柰酚、木樨草素、黄芩素、芒柄花黄素等;有效成分与强直性脊柱炎共同作用靶点82个,包括白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子(tumor necrosis factor,TNF)、血管内皮生长因子(vascular endothelial growth factor A,VEGFA)等;GO富集分析功能条目366条,其中生物过程(biological process,BP)284条,细胞组分(cellular component,CC)31条,分子功能(molecular function,MF)51条,包括细胞对脂多糖的反应、类固醇激素受体活性等;KEGG信号通路共87条,主要核因子kB(nuclear factor-k-gene binding,NF-κB)信号通路、核苷酸寡聚化结构域(nucleotide oligomerzation domain,NOD)样受体信号通路、缺氧诱导因子1(hypoxia inducible factor-1,HIF-1)信号通路等.结论:补阳还五汤治疗强直性脊柱炎主要是通过槲皮素、山柰酚、木樨草素、黄芩素、芒柄花黄素等活性成分作用于VEGFA、IL-10、基质金属蛋白酶9(matrix metallopeptidase 9,MMP9)、前列腺素内过氧化物合酶2(prostaglandin-endoperoxide synthase 2,PTGS2)等靶点基因,从而调节多条生物学功能与信号通路,最终达到治疗作用.

目的:观察耳穴压豆法对缓解跟骨骨折术后疼痛的临床疗效.方法:选取跟骨骨折行外侧L形入路切开复位术后的患者72例,采用随机数字表法分为对照组与治疗组,对照组和治疗组各36例.对照组采用静脉镇痛泵、冰敷,治疗组采用静脉镇痛泵、冰敷联合耳穴压豆.治疗7 d后采用疼痛视觉模拟评分(VAS)评定跟骨骨折术后疼痛改善情况,记录术后止痛药物服用与不良事件发生情况,调查患者满意率.结果:71例患者获得随访.VAS评分:时间因素与分组因素存在交互效应,且术后1～7 d治疗组止痛效果优于对照组,差异有统计学意义(P＜0.0 5).止痛药物服用率:治疗组5.5 6％,对照组97.14％,差异有统计学意义(P＜0.05).不良反应发生率:治疗组13.89％,对照组74.29％,差异有统计学意义(P＜0.05).患者满意率:治疗组91.67％,对照组85.71％,差异有统计学意义(P＜0.05).结论:耳穴压豆法治疗跟骨骨折术后止痛效果良好,止痛药物服用率低,不良反应发生率低,患者满意度高,值得临床推广应用.

目的 基于网络药理学的研究方法,探讨黄芪-桂枝药对治疗类风湿关节炎的作用机制.方法 通过中药系统药理学数据库与分析平台(TCMSP)及GeneCards、OMIM等数据库搜索药物、疾病的共同作用靶点,制作韦恩图;利用String数据库、Cytoscape 3.6.1软件构建药物疾病共同靶点蛋白互作网络、药物-成分-疾病-靶点网络;最后通过DAVID数据库对共同靶点进行基因本体(gene ontology,GO)、京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)富集分析,并将富集结果可视化.结果 黄芪-桂枝药对治疗类风湿关节炎的主要成分是槲皮素、山柰酚、刺芒柄花素、7-O-甲基异丁香酚、β-谷甾醇等;关键作用靶点为TNF、IL6、JUN、IL1B、CCL2、CXCL8、IL10、ICAM1、MAPK1、PTGS2等;关键作用通路为 TNF信号通路、Toll样受体信号通路、HIF-1信号通路、T细胞受体信号通路、细胞凋亡、PI3K-Akt信号通路等.结论 黄芪-桂枝药物有效成分通过多靶点、多通路产生抑制炎症反应、免疫功能调节、滑膜血管增殖、细胞凋亡等作用治疗类风湿关节炎.

目的:探讨在仰卧定点复位法中术者沿水平横向发力与斜向发力对神经根型颈椎病患者的临床疗效差异.方法:将63例神经根型颈椎病患者随机分为两组,旋转复位组手法采用水平横向发力,旋推复位组手法采用斜向发力,采集首次就诊及治疗2周后的模拟视觉评分(VAS评分)、颈椎功能障碍指数(NDI指数).结果:两组神经根型颈椎病患者在治疗2周后均能使VAS评分及NDI指数评分得到显著改善(P＜0.01),且旋推复位组改善显著优于旋转复位组(P＜0.01).结论:仰卧定点复位法中采用旋推复位法治疗神经根型颈椎病能够在2周的治疗时间内,缓解疼痛、改善颈椎功能,该方法能够较传统旋转复位法取得更显著的临床疗效.

目的 探讨使用中药熏藤方足浴治疗气滞血瘀型跟痛症的临床疗效.方法 选取骨一科2016年9月-2018年8月收治的气滞血瘀型跟痛症患者80例,患者均为单足发病.按照随机数字表法分为治疗组和对照组,对照组患者予口服非甾体消炎药塞来昔布胶囊治疗,治疗组患者予中药熏藤方足浴治疗,观察2组治疗效果.结果 治疗组患者治疗的总有效率为92.5％,明显优于对照组的67.5％.2组患者中均未发现明显不良反应.结论 中药熏藤方治疗气滞血淤型跟痛症效果(P＜0.05)较好,临床应用价值较高.

难治性胃食管反流病在消化内科门诊就诊人数中占有相当大的比例.目前,在西医正规治疗下仍有一部分人的反流症状未能得到明显改善.近年来中医药对该病的研究取得了较大进展,与西医相比,在改善患者症状方面中医药凸显出较大的优势,但目前为止尚未就其辨证分型得到统一.导师李培教授多年来潜心研究中医中药对该疾病的治疗方法,创造性的提出了“主以辛开,辅以苦降”的方法治疗该疾病,临床收效满意.

目的 观察复元活血汤加减联合常规抗血栓治疗对股骨颈骨折人工全髋关节置换术后患者血液高凝状态及深静脉血栓形成(DVT)的影响.方法 将116例股骨颈骨折人工全髋关节置换术患者按照随机数字表法分为2组,对照组56例术后予常规抗血栓治疗,治疗组60例在对照组治疗基础上加用复元活血汤加减治疗,连续治疗14 d.比较2组术前及术后3、7、14 d凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和血浆D-二聚体(D-D)水平及术后2周DVT发生率,比较2组术后输血量、48 h引流量及术后3d大腿、小腿周径,术后3、7、14 d血栓溶解疗效,术后6个月关节功能疗效.结果 治疗组术前和术后3、7、14 d凝血指标及血浆D-D水平两两比较差异均有统计学意义(P＜0.05),随着术后时间的延长,PT、APTT明显延长,FIB、TT、D-D水平明显下降;对照组术后7、14 d凝血指标及术后3、7、14 d血浆D-D水平与本组术前比较差异均有统计学意义(P＜0.05),且术后7、14 d凝血指标和D-D水平与本组术后3d比较差异有统计学意义(P＜0.05);治疗组术后第3、14dPT、APTT长于对照组(P＜0.05),FIB、TT、D-D水平低于对照组(P＜0.05);术后7d,治疗组PT、FIB、TT与对照组同期比较差异有统计学意义(P＜0.05).2组术后输血量及术前大腿、小腿周径比较差异无统计学意义(P＞0.05),治疗组术后48 h引流量低于对照组(P＜0.05);2组术后3d大腿、小腿周径均较本组术前明显增加(P＜0.05),但治疗组小于对照组(P＜0.05).治疗组术后第3、7、14 d血栓溶解总有效率分别为77.77％、88.89％、94.44％,对照组分别为55.17％、65.52％、68.96％,治疗组术后第7、14 d血栓溶解总有效率明显高于对照组(P＜0.05).术后6个月,治疗组关节功能总优良率(95.00％)高于对照组(80.36％,P＜0.05).结论 复元活血汤加减联合常规抗血栓治疗能显著降低股骨颈骨折人工全髋关节置换术术后患者血液高凝状态,降低血液黏稠度,促进血栓溶解和血管再通,降低DVT发生率.

经皮给药系统近年来发展迅速,随着促渗剂的改进、以及离子导入、激光、电致孔、超声导人等新技术的发展,低频超声经皮促透药物广泛应用于临床实践,并引起了研究者的研究兴趣.本文就低频超声的作用机制、影响作用效益的因素、动物实验研究以及安全性评估展开综述.

OBJECTIVETo observe X-ray features of before and after treatment of cervical imbalance syndrome with osteopathy and traction intervention in youth patients, then to investigate the clinical effect of the treatment of the cervical imbalances syndrome in youth by osteopathy.METHODSFrom September 2007 to December 2010, one hundred and eighty-seven students of 19 to 22 years (means 21 years) with neck pain as the main symptom in Beijing university of Chinese medicine were selected and divide them into osteopathy group and traction groups randomly. In osteopathy group, there were 94 patients including 40 males and 54 females; in traction group, there were 93 patients including 42 males and 51 females. The treatment of osteopathy group lasted for 3 weeks,three times per week; traction group by traction treatment three weeks,three times a week, too. X-ray before treatment and 3 weeks after treatment were collected.RESULTSThe osteopathy group:94 cases, before treatment, abnormal curvature in 57 cases, spinous position change in 45 cases and angular displacement in 44 cases, vertebral sliding in 15 cases, Ruth Jackson line intersect proneness change in 70 cases,stretch change in 47 cases; after treatment, abnormal curvature in 35 cases, spinous position change in 24 cases and angular displacement in 18 cases, vertebral sliding in 3 cases, Ruth Jackson line intersect proneness change in 41 cases, extension change in 33 cases; X-Ray measurement results: cervical curvature improved from (7.070 +/- 4.629) degrees before treatment to (7.660 +/- 4.156) degrees after treatment, angular displacement improved from (13.790 +/- 2.590) degrees before treatment to (11.050 +/- 2.560) degrees after treatment; vertebral sliding improved from (3.770 +/- 0.350) mm before treatment to (3.160 +/- 0.485) mm after treatment. The change of angular displacement and vertebral sliding were so significant before and after treatment in this group, there were statistical defferences between before and after the treatment (P < 0.01) in osteopathy group. The traction group: 93 cases, before treatment,abnormal curvature in 60 cases, spinous position change in 39 cases and angular displacement in 39 cases, vertebral sliding in 15 cases, Ruth Jackson line intersect proneness change in 70 cases, stretch in 47 cases; after treatment,abnormal curvature in 50 cases, spinous position change in 29 cases and angular displacement in 17 cases; vertebral sliding in 3 cases, Ruth Jackson line intersect proneness change in 41 cases, stretch in 33 cases; X-Ray measurement results: cervical curvature improved from (5.590 +/- 4.639) degrees before treatment to (5.990 +/- 4.330) degrees after treatment, angular displacement improved from (13.360 +/- 2.064) degrees before treatment to (11.210 +/- 1.872) degrees after treatment; vertebral sliding improved from (3.790 +/- 0.339) mm before treatment to (3.480 +/- 0.332) mm after treatment. The change of angular displacement and vertebral sliding were also so significant in traction group before and after treatment, there were statistical defferences between before and after the treatment (P < 0.01).CONCLUSION(1) Pathological changes can be called youth cervical imbalance syndrome. (2) Stress points, angular displacement, cervical vertebral slip, curvature straightened, spinous position change are main X-ray performances. (3) Both osteopathy and traction intervention on are efficient in youth neck pain. (4) Youths cervical vertebra imbalance is early but reversible performance.

Objective To observe the clinical curative effects of self-made Jianbu Decoction for external washing in the treatment of knee osteoarthritis with syndrome of cold-damp obstructing the collaterals(KOA).Methods 60 patients with knee osteoarthritis of syndrome of cold-damp obstructing the collaterals were randomly divided into the Jianbu Decoction for external washing group(Chinese medicine external washing group) and the Voltaren Ointment for external coating group(control group).The Chinese medicine external washing group used self-made Jianbu Decoction for the external washing of knee joint twice per day and 30 minutes per time while the control group used Voltaren Ointment for external coating twice per day,with 14 days as one treatment course.With the WOMAC score as the evaluation standards,the curative effects of both groups were observed.Results After treatment,the pain,physical function,stiffness scores and other scores significantly reduced compared with those before treatment(P 0.05).One week later,the pain,physical function,stiffness scores and other scores between the two groups showed no statistically significant differences(P 0.05).Two weeks later,the pain,physical function,stiffness scores and other scores between the two groups showed no statistically significant differences(P 0.05).Conclusion The self-made Jianbu Decoction for external washing has similar curative effects with the control group in the treatment of KOA of syndrome of cold-damp obstructing the collaterals after one week,but has superior curative effects to the control group after two weeks.The self-made Jianbu Decoction for external washing has positive curative effects in the treatment of KOA,thereby worthy of promotion and further research into its mechanism.

Objective To observation the effect on the Zhongtong'an Capsule and Duyiwei Capsule in the treatment of knee osteoarthritis with the syndrome of phlegm and blood stasis.Methods 120 patients with knee osteoarthritis with the syndrome of phlegm and blood stasis were divided into treatment group and control group,treatment group and control group were given Zhongtong'an Capsule and Duyiwei Capsule respectively,2 grains,3 times a day.Symptoms and signs score,WOMAV score,general efficacy of two groups were observed before and after treatment.Results There were no significant differences in Symptoms and signs score and WOMAV score between the two groups before treatment and after treatment of 2 weeks(P 0.05).There were significant differences in Symptoms and signs score and WOMAV score after treatment(P = 0.047,0.035).there was significant difference in the general efficacy between the two groups after treatment(P = 0.041).Conclusion Zhongtong'an Capsule has a better effect in the treatment of knee osteoarthritis with the syndrome of phlegm and blood stasis,which compared with Duyiwei Capsule,so it is worthy to be popularized and studied its mechanism of action.

OBJECTIVE To compare the temperature distribution of both sides of shoulder, provide objective reference for the application thermoview in the diagnosis of cervicodynia in teenagers. METHODS Forty-five adolescents with cervicodynias from March 2009 to December 2009 were collected. There were 23 males and 22 females, with an average age of 21 years (ranged from 19 to 22 years). The course of disease ranged from 2 to 20 weeks (averaged 13 weeks). C7 horizontal line were used to divide the back into the neck area and shoulders area, and the midline to subdivide the chosen area into left and right area. Thermal infrared imaging was used to observe the temperature both sides of neck and shoulders, the data was analyzed by the computer. RESULTS The temperature of shoulder was higher than neck. There were significant differences in the highest and average temperature both of the left and right side of neck and shoulder (P < 0.05), but no difference in the lowest temperature both of left and right side of neck. CONCLUSION The thermal infrared imaging is important for diagnosing cervical imbalance syndrome, finding the sign of abnormal muscle metabolism of shoulder and providing the basis for prevention.

女性尿失禁是需长期治疗的顽固症.体外电磁波刺激(extracorporeal magnetic innervations,ExMI)和可携式功能性磁环刺激(functional electrical magnetic stimulation,FES)以及植入式骶骨神经调节治疗是目前认为是颇具潜力的疗法,治疗压力性、尿急性尿失禁、频尿综合征(过动性膀胱)、间质性膀胱炎和排尿功能障碍等,短期即显示有可观的疗效和改善,但长期疗效仍期待更多的临床观察.