ObjectiveThe aim of this study was to observe the clinical efficacy and safety of conventional treatment combined with acupuncture in the treatment of idiopathic deafness.MethodsThis retrospective study enrolled 141 patients with idiopathic deafness hospitalized from January 2018 to December 2019. We compared the patients according to previous therapy (conventional treatment and acupuncture treatment), demographics, type of deafness, pure tone hearing threshold score, concomitant symptoms, adverse events and outcomes.ResultsA total of 141 patients were assigned to a control group (n = 67, with simple routine Western medicine treatment) and an observation group (n = 74, with acupuncture treatment on the basis of Western medicine therapy). The total effective rate was 98.65% in the observation group, compared with 74.63% in the control group (p < 0.001). The tinnitus and vertigo were both improved in both groups, and the observation group was better than the control group (p < 0.05). Adverse reactions occurred in one patient (1.35%) in the observation group and in five patients (7.46%) in the control group (p = 0.085).ConclusionAmong patients with idiopathic deafness who can be treated after the onset of symptoms, the combination of acupuncture and conventional treatment is superior to conventional treatment alone for improving clinical efficacy, reducing concomitant symptoms and not increasing the risk of adverse events.

To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations. We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met the requirements. The methodology quality of the included studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. Data pertaining to diagnostic performance were extracted, and the pooled sensitivity and specificity were calculated using a bivariate mixed-effects model. We included six studies with a total of 132 patients with arteriovenous malformation (AVM). The merged sensitivity and specificity of ASL for the diagnosis of brain AVMs with incomplete occlusion after treatment were 0.94[0.86–0.98] and 0.99 [0.59-1.00], respectively. According to the SROC curve summary, the AUC was found to be 0.98 [0.96–0.99]. No significant publication bias was observed. While ASL does not currently match the diagnostic precision of DSA, it is instrumental in post-treatment surveillance of AVM patients. With the development of ASL technology in the future, this technique holds promise as a minimally invasive diagnostic strategy for AVMs with fewer side effects. CRD42023422087. Not applicable.

Introduction: To conduct a comprehensive evaluation of the efficacy and safety of combining traditional Chinese medication (TCM) with Western medication to improve secondary stroke prevention. Through meticulous analysis, we investigate the combined approach's potential to yield superior outcomes compared to stand-alone Western medical treatments. Methods: We rigorously searched for RCTs on secondary stroke prevention using TCM and Western medicine (WM) from database creation to October 2023. PubMed, EMBASE, Cochrane Library, CNKI, SinoMed, WanFang, and VIP yielded pertinent studies. Stata 16.0 was used for comprehensive meta-analyses with predetermined inclusion and exclusion criteria. Results: This thorough review comprised 40 randomised controlled trials with 3 478 treatment and 3 396 control participants. Combining TCM and WM significantly enhances secondary stroke prevention rates compared to WM alone (OR = 0.83, 95% CI: 0.55-1.12, P < 0.001). Compared to Western medical treatment for secondary stroke prevention, the integrated strategy significantly lowered the National Institutes of Health Stroke Scale score (OR =-0.62, 95% CI:-0.89,-0.35, P < 0.001). Furthermore, this integrated strategy effectively reduced stroke recurrence rates compared to Western medical therapy alone (OR =-0.94, 95% CI:-1.10,-0.76, P < 0.001). The rate of adverse reactions was not significantly different between Western medical treatment and integrated TCM (OR = 0.01, 95% CI: -0.18, 0.05, P = 0.131). Conclusions: The evidence shows that combining TCM and Western therapy improves secondary stroke prevention. Besides improving clinical effectiveness, this integrated approach may reduce stroke recurrence. These findings strongly support the widespread use of this integrated approach in clinical practice.

Objective To explore the clinical efficacy of Xiaoshuan enteric-coated capsule (XSECC) in treating cerebral infarction and its potential mechanism of action. Methods Patients with acute ischemic stroke (AIS) of the qi deficiency and blood stasis type were randomly assigned to the control and observation groups. They were evaluated using the National Institutes of Health Stroke Scale (NIHSS), Activities of Daily Living (ADL), Hachinskilnchemic Scale (HIS), Barthel Index (BI), clinical efficacy scores, and TCM syndrome scores on days 0, 14, 30, and 90. Furthermore, VEGF and BDNF levels were measured on days 30 and 90. Finally, we analyzed the changes in each scale score and vascular neurological factor in both groups. Results After 14 days of treatment, the difference values in NIHSS, ADL, and BI were higher, and TCM syndrome and clinical efficacy scores were increased in the observation group compared with those of the control group (all P < .05). After 30 days, the NIHSS, ADL, HIS, and TCM syndrome scores were decreased compared with those of the control group, while BI and clinical efficacy scores were increased (all P < .05). After 90 days, the difference value in ADL was higher, and TCM syndrome score was increased in the observation group compared with that of the control group (P = .047, P = .005, respectively). The levels of VEGF and BDNF were higher in the observation group than in the control group on days 14, 30, and 90 (all P < .05). VEGF and BDNF levels on day 0 were associated with prognosis of patients with AIS; therefore, they have a predictive value for the prognosis of acute cerebral infarction. Conclusions XSECC therapy can improve clinical outcomes in patients with acute and recurrent cerebral infarctions. Its mechanism of action may be associated with the secretion of VEGF and BDNF.

Background: Currently, depression is diagnosed on the basis of neuropsychological examinations and clinical symptoms, and there is no objective diagnostic method. Several studies have explored the application of microRNAs as potential biomarkers diagnostic for depression. This study aims to determine the diagnostic value of microRNAs for depression. Methods: PubMed, Embase, the Cochrane Library, the Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Databaseand China National Knowledge Infrastructure were searched up to 11 January 2022. Stata (version 16.0) and RevMan (version 5.3) software were used for meta-analysis. The pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio (DOR) were calculated; the summary receiver operating characteristic (SROC) curve was plotted, and the area under the curve (AUC) was calculated. Moreover, meta-regression analyses were performed to determine the source of heterogeneity. Deeks' funnel plot test was used to assess publication bias.Results: In total, 677 patients were enrolled, including 364 patients with depression and 313 healthy controls. Meta-analysis results showed that the pooled sensitivity, specificity, and DOR of microRNAs for the diagnosis of depression were 0.82 [95% confidence intervals(CI): 0.76, 0.87], 0.70 (95% CI: 0.62, 0.77), and 11 (95% CI: 6, 20), respectively, and the AUC of the SROC was 0.84 (95% CI: 0.80, 0.87).Conclusions: MicroRNAs have high sensitivity and specificity in diagnosing depression and are potential diagnostic biomarkers for depression. Registration number: PROSPERO CRD42022303616.

Objective:To establish a simple and explainable model and provide reference for improving the accuracy of model prediction in similar research.Methods:The data（heart failure grade and related factors） of 200 patients with pulmonary fibrosis complicated with heart failure in a research project supported by the National Natural Science Foundation of China（81673904） were collected.The Lasso regression was employed to screen out the characteristic variables from sex, age, body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure, total cholesterol（TC）,fasting blood glucose, tongue color, tongue coating color, and traditional Chinese medicine（TCM） physique.A regression model was established to explore the relationship between the severity of heart failure and the characteristic variables.Results:After removal of the confounding factors in high-dimensional data, six characteristic variables were selected for the model, including BMI（0.006 357 091）,SBP（0.219 695 622）,TC（0.229 324 833）,red tongue（0.004 216 705）,thin white tongue coating（-0.825 660 057）,and thick yellow tongue coating（0.356 499 153）.The probability of severe heart failure was P=-33.632+0.006×BMI+0.220×SBP+0.229×TC+0.004×red tongue-0.826×thin white tongue coating+0.356×thick yellow tongue coating.Conclusion:The established model can explain the factors associated with severe heart failure and be applied to the prediction in the population.Lasso regression model is suitable for high-dimensional data analysis of TCM clinical research, demonstrating the value for promotion.

气血和脏腑理论被广泛应用于多种临床疾病的治疗中.缺血性脑血管病各期病机演变与肝脾肾功能密切相关,从脏腑立论,本病根本病机是肝肾亏虚、脑窍失养,发病关键是肝失疏泄、气机逆乱,病理基础是脾虚失运、痰瘀内生.该病风、火、痰、瘀、虚各证候要素的变化又与气血的动态变化密不可分,故从气血立论,其病机又可概括为气血逆乱和气虚血瘀.本文基于气血和脏腑理论认为,缺血性脑血管病的治疗需结合气血与脏腑辨证,急性期急则治标,宜疏肝、清肝、平肝兼破血逐瘀;恢复期标本兼治,宜调肝健脾兼活血化瘀;后遗症期治病求本,宜补肝肾、健脾兼补气活血化瘀.

To estimate the diagnostic value of contrast-enhanced MR angiography (CE-MRA) in identifying residual brain arteriovenous malformations (AVMs) after treatment. We retrieved appropriate references from the electronic databases of PubMed, Web of Science, Embase, and Cochrane Library, and then evaluated the methodology quality of included references using the QUADAS-2 tool. We calculated the pooled sensitivity and specificity by applying a bivariate mixed-effects model and detected the publication bias using Deeks’ funnel plot. The values of I2 were used to test heterogeneity and meta-regression analyses were performed to search for the causes of heterogeneity. We included 7 eligible studies containing 223 participants. Compared with a gold standard, the overall sensitivity and specificity of CE-MRA in detecting residual brain AVMs were 0.77 (95

Background Mitochondrial dysfunction leading to disturbances in energy metabolism has emerged as one of the risk factors in the pathogenesis of depression. Numerous studies have identified alterations in the content of mitochondrial DNA (mtDNA) in peripheral blood and cerebrospinal fluid of individuals with depression. Researchers have sought to establish a clear association between mtDNA and depression. Consequently, we conducted a comprehensive meta-analysis to assess the existing evidence regarding the impact of mtDNA on depression. Methods This study conducted a thorough search of the following databases up to March 13, 2023: PubMed, Embase, the Cochrane Library, the Web of Science, Wanfang Database, SINOMED, the China Science and Technology Journal Database, and China National Knowledge Infrastructure. The meta-analysis was carried out using RevMan (version 5.4) and Stata (version 16.0) software. In addition, publication bias was assessed with funnel plots, Begg’s test and Egger’s test. Results Our analysis included data from 10 articles, including 12 studies for further examination. A total of 1400 participants were included in this study, comprising 709 (including 300 males and 409 females) patients with depression and 691 (including 303 males and 388 females) healthy controls. The average age of depressed patients was (42.98 ± 2.55) years, and the average age of healthy people was (41.71 ± 2.6) years. The scales used to assess outcomes are Hamilton-rating scale for Depression(4 articles), Montgomery-Asberg Depression Rating Scale(3 articles), and Mini-Internatioal Neuropsychiatric Interview (1 articles). The meta-analysis revealed significantly higher levels of mtDNA in circulating blood samples and skin fibroblasts of individuals with depression in comparison to healthy controls [standardized mean difference(SMD) = 0.42, 95% confidence intervals(CI): 0.16, 0.67]. Conclusions Our study concludes that there is a significant (p < 0.05) increase in mtDNA levels in serum, plasma, and cerebrospinal fluid in individuals with depression. These findings suggest that mtDNA could serve as a potential biomarker for diagnosing depression. Registration number PROSPERO CRD42023414285.

目的:基于数据挖掘技术探讨针刺治疗广泛性焦虑障碍的穴位配伍规律.方法:利用计算机检索中国知网、万方、维普、中国生物医学文献数据库、Cochrane Library、Pubmed、Web of science及Embase 8个中英文数据库,收集针刺治疗广泛性焦虑障碍的相关文献,建立针刺处方数据库,采用SPSS Statistics 25.0、SPSS Modeler 18.0软件对腧穴进行描述性分析、聚类分析和关联规则分析.结果:纳入70篇文献,涉及91个腧穴,累计用穴611次.针刺治疗广泛性焦虑障碍的腧穴以百会、神门与内关为主;应用频次较高的经脉为督脉、足太阳膀胱经与手厥阴心包经;特定穴使用频率从高到低依次为交会穴、五输穴与原穴等,常与关联度最高的"百会-印堂"组合配伍使用.高频腧穴聚类分析得到5个聚类群:脾俞-肾俞-厥阴俞-心俞-肝俞-胆俞-申脉-照海;大陵-曲池-上星-劳宫-水沟-风府;中脘-天枢-气海-关元-足三里-太溪;丰隆-期门-膻中-行间;神门-太冲-百会-内关-神庭-四神聪-太阳-印堂-三阴交-风池-本神-合谷.结论:针灸治疗广泛性焦虑障碍选穴以宁心安神、通督醒脑为原则,注重使用特定穴,呈现以"百会-内关-神门"为基础的针刺处方.

The efficacy and safety of edaravone for the treatment of amyotrophic lateral sclerosis (ALS) remain unclear. The aim of this meta-analysis was to provide evidence-based medical guidance and advice for the clinical application of edaravone in the treatment of ALS. PubMed, Embase, Chinese Biomedical Literature Database (CBM), Cochrane Library and Web of Science were searched through 09 March 2022 for randomized controlled trials (RCTs) on the safety and efficacy of edaravone versus placebo during follow-up of patients with ALS. A summary of the outcome measures with GRADE was performed. This study was registered on PROSPERO (ID: CRD 42022319997). Five RCTs with a total of 566 participants were included, and there was a significant difference (mean difference [MD] 1.33, 95

目的:观察滋阴泻火汤治疗绝经期睡眠障碍的临床疗效.方法:选择绝经期睡障碍患者78例,随机分为对照组和观察组各39例.对照组采用西医常规治疗,观察组内服滋阴泻火汤,两组共治疗4周.比较两组治疗前后临床疗效,睡眠质量(包括入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍)评分、雌二醇(estradiol,E2)、促卵泡激素(follicle stimulating hormone,FSH)、促黄体素(luteiniz-ing hormone,LH)水平及不良反应发生情况.结果:观察组总有效率[92.31％(36/39]与对照组[87.18％(34/39)]比较,差异无统计学意义(P>0.05).治疗后两组睡眠质量各项评分及总分均较治疗前降低(P<0.05);且观察组各项指标降低较对照组更明显(P<0.05).停药4周后随诊,对照组各项评分及总分较治疗后升高(P<0.05);观察组各项评分及总分较治疗后无明显差异(P>0.05);观察组各项评分及总分均明显低于对照组(P<0.05).与对照组治疗后比较,观察组E2水平(P<0.05),FSH、LH水平降低(P<0.05).观察组不良反应发生率[0％(0/39)]低于对照组[10.26％(4/39)](P<0.05).结论:滋阴泻火汤治疗绝经期女性睡眠障疗效显著、作用持久,且无明显不良反应.

Objective: To compare the clinical effect of traditional Chinese and Western Medicine on postoperative abdominal distension of lumbar degenerative diseases.Methods: A total of 202 patients with lumbar degenerative diseases who underwent internal fixation from January 1,2020 to February 1,2022 were randomly divided into control group and observation group, with 101 cases in each group.The patients in the control group were givenabdominal ultrasound physiotherapy after operation.At the same time, they were given lactulose oral liquid once a day the next day after operation.Some patients with severe abdominal distension or even abdominal pain were given enema, anal exhaust, or gastrointestinal decompression or short-term fasting.The observation group received abdominal ultrasound physiotherapy, abdominal and lower limb massage and oral Chengqi Decoction.The clinical effects were observed at 12,24 and 48 hours after treatment.Visual analogue scale（VAS） was used to evaluate the abdominal distension and pain of the two groups after treatment.The remission time of abdominal distension, the first exhaust and defecation time and defecation times in one week were compared between the two groups.Results: The total effective rate was 94% in the observation group and 80% in the control group, the difference was statistically significant（P＜0.05）.There was no significant difference in VAS score between the two groups before treatment（P＞0.05）.After 12 h, 24 h and 48 h of treatment, the VAS scores of the two groups were significantly lower than those before treatment（P＜0.05）,and the VAS score of the observation group was lower than that of the control group at the same time point（P＜0.05）.The remission time of abdominal distension and the first exhaust and defecation time in the observation group were significantly earlier than those in the control group（P＜0.05）,and the defecation times in one week were significantly more than those in the control group, the difference was statistically significant（P＜0.05）.Conclusion: manual massage combined with oral Chengqi Decoction can significantly improve the symptoms of abdominal distension in patients with lumbar degenerative disease.

目的 基于代谢组学技术寻找痰热内扰型慢性失眠病人的差异性血清代谢物,分析慢性失眠痰热内扰证病人经黄连温胆汤治疗前后血清代谢物的变化,初步揭示黄连温胆汤对痰热内扰型慢性失眠的干预作用.方法 选取2019年8月—2020年12月自愿参加本研究的痰热内扰型慢性失眠病人36例作为慢性失眠组,选取同期健康受试者36名作为健康对照组,其中,慢性失眠组脱落3例,最终纳入33例.慢性失眠组给予黄连温胆汤免煎颗粒(组方:黄连、法半夏、竹茹、橘红、麸炒枳实、茯神、甘草、生姜、大枣),每日1剂,上下午分服,治疗4周.健康对照组不予干预.慢性失眠病人治疗前后及健康受试者均进行空腹静脉采血,采用液相色谱-质谱联用(LC/MS)技术对收集的血清样本进行检测,使用多元统计分析法寻找血清代谢物,利用MetaboAnalyst 4.0软件筛选出差异性代谢物及其涉及的代谢通路.结果 与健康对照组比较,慢性失眠组病人血清中上升的代谢物质有L-乙酰肉碱、L-亮氨酸、L-缬氨酸、溶血磷脂酰胆碱(LysoPC)[20:3(5Z,8Z,11Z)]、LysoPC(17:0)、组胺、磷脂酰胆碱(PC)[18:1(9Z)/20:4(5Z,8Z,11Z,14Z)];下降的物质有肌酸、L-苯丙氨酸、L-色氨酸、鞘磷脂(SM)[d18:0/18:1(11Z)]、油酸、PC[18:3(6Z,9Z,12Z)/16:0]、二十二碳六烯酸.与治疗前比较,经黄连温胆汤治疗后,慢性失眠组病人血清中上升的物质有LysoPC[18:2(9Z,12Z)]、LysoPC[20:4(8Z,11Z,14Z,17Z)]、LysoPC[18:1(11Z)]、L-苯丙氨酸、L-亮氨酸、肌酸、L-色氨酸;下降的物质有PC[16:1(9Z)/20:3(8Z,11Z,14Z)]、PC[16:1(9Z)/22:2(13Z,16Z)]、L-肉碱、SM[d18:0/18:1(11Z)]、PC[18:1(9Z)/20:4(5Z,8Z,11Z,14Z)]、SM[d18:0/16:1(9Z)]、PC[o-16:1(9Z)/20:4(8Z,11Z,14Z,17Z)]、2-羟基丁酸、L-乙酰肉碱、SM(d18:1/16:0).结论 痰热内扰型慢性失眠病人体内存在磷脂代谢、氨基酸代谢、能量代谢、脂肪酸代谢等异常,黄连温胆汤对痰热内扰型慢性失眠干预作用与调节氨基酸代谢、脂质代谢、能量代谢有关.

探析情志所致胃痛的发病机制,胃痛发病在胃,源于肝,主因情志失常,影响肝的疏泄功能.一是忧思恼怒致肝气郁结,气机阻滞,肝气疏泄不及,木郁克土,横逆犯胃;二是暴怒伤肝、肝郁化火,肝气疏泄太过横逆犯胃.肝气横逆犯胃致胃失和降,胃气上逆,即为"肝胃不和".基于"肝胃不和"理论,情志所致胃病分为肝气郁结和肝郁化火所致胃痛,治疗上应予疏肝和胃止痛和泄肝和胃止痛.

目的:系统评价氯吡格雷联合阿托伐他汀对脑梗死患者炎症反应、血液流变学和凝血功能等指标的影响,为更好地指导临床用药提供参考.方法:检索PubMed、the Cochrane Library、Embase、中国生物医学文献数据库、中国知网、维普数据库和万方数据库,收集从建库至2021年11月氯吡格雷联合阿托伐他汀治疗脑梗死的随机对照试验(对照组患者采用氯吡格雷或氯吡格雷+常规治疗,研究组患者在对照组基础上联合应用阿托伐他汀治疗),应用RevMan 5.4.1软件进行Meta分析及偏倚风险评估,应用GRADE系统进行证据质量评估分级.结果:共纳入24篇文献,研究组患者1107例,对照组患者1106例.Meta分析结果显示,研究组患者的超敏C反应蛋白(MD=-3.25,95％CI=-3.77～-2.73,P<0.00001)、肿瘤坏死因子 α(SMD=-1.31,95％CI=-1.51～-1.11,P<0.00001)、血浆黏度(MD=-0.42,95％CI=-0.60～-0.24,P<0.00001)、红细胞聚集指数(MD=-0.82,95％CI=-1.37～-0.26,P=0.004)、纤维蛋白原(MD=-0.99,95％CI=-1.85～-0.12,P=0.03)、D-二聚体(SMD=-2.38,95％CI=-3.52～-1.24,P<0.00001)和凝血酶原时间(MD=1.92,95％CI=1.22～2.62,P<0.00001)等指标水平均明显优于对照组,差异均有统计学意义;两组患者红细胞比容水平(SMD=-0.33,95％CI=-1.09～0.42,P=0.38)和活化部分凝血酶原时间(MD=1.22,95％CI=-1.81～4.26,P=0.43)的差异无统计学意义.GRADE系统评价显示,证据等级为低或极低质量,推荐强度为弱推荐.结论:当前证据表明氯吡格雷联合阿托伐他汀可以降低脑梗死患者的炎症反应,改善血液流变学水平和凝血功能.因纳入研究证据等级较低,上述结果具有一定的局限性,仍需更多高质量、高标准的研究进一步论证.

脑卒中后致残的成因复杂,而脑卒中后认知功能障碍(PSCI)因其高发病率已成为其中一个重要原因.本研究主要从流行病学、临床表现、诊断依据、综合管理及治疗、医学影像学评价等方面系统地阐述PSCI的最新研究进展,以期为临床早期诊断和防治PSCI提供参考依据.

目的 对依达拉奉超适应症用药治疗病毒性脑炎的有效性及安全性进行循证医学评价.方法 检索中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文期刊全文数据库(VIP)、万方数据库、the Cochrane Library、PubMed和Embase数据库中有关依达拉奉治疗病毒性脑炎的随机对照试验(RCT);检索时间从建库至2021年11月3日.利用RevMan 5.4.1软件进行数据分析、Cochrane手册5.1.0风险偏倚评估工具进行偏倚风险评估、GRADE系统进行证据质量评估分级.结果 共纳入14项RCTs,包含1128例患者.Meta分析显示:试验组的有效率高于对照组[RR=1.20,95％CI(1.14,1.26),P＜0.000 01];并且较对照组能显著降低血清神经元特异性烯醇化酶(NSE)水平[SMD=-1.73,95％CI(-2.28,-1.18),P＜0.000 01]、血清S100B蛋白浓度[MD=-0.11,95％CI(-0.13,-0.10),P＜0.000 01]、脂质过氧化物(LPO)浓度[MD=-1.42,95％CI(-1.95,-0.89),P＜0.000 01]和美国国立卫生研究院卒中量表(NIHSS)评分[MD=-3.19,95％CI(-7.11,0.73),P=0.11],但血清过氧化氢酶(CAT)浓度[MD=0.98,95％CI(0.66,1.30),P＜0.000 01]则显著高于对照组;不良反应或并发症发生率与对照组比较差异无统计学意义[RD=-0.04,95％CI(-0.15,0.07),P=0.51].GRADE评估为低或极低质量证据,推荐强度为弱推荐.结论 当前证据表明依达拉奉超适应症治疗病毒性脑炎具有一定的有效性和安全性,但因纳入研究证据等级较低,样本量较少,故此结论仍需要更多高质量、高标准的研究证明.

目的 探讨再住院精神分裂症患者药物依从性的相关因素.方法 回顾性分析2016年5月至2018年5月北京市怀柔安佳医院收治的180例再住院精神分裂症患者的年龄、性别、病程、婚姻、就业、文化程度、家族史、居住环境、药物类型、自知力、严重精神疾病危险性分级、免费服药、经济情况、残疾鉴定资料.采用Morisky服药依从性问卷(MAQ-8)将评分＜6分者分为依从性差组(112例),6～8分者分为依从性较好组(68例),并用logistic回归分析再住院精神分裂症患者药物依从性的相关因素.结果 单因素分析结果显示,两组患者的就业情况、居住环境、药物类型、自知力、严重精神疾病危险性分级比较,差异有统计学意义(P＜0.05).logistic回归分析结果显示,自知力缺乏(β=1.338,OR=3.811,95％CI=2.362～6.148)、严重精神疾病风险性分级≥2 级(β=1.213,OR=3.363,95％CI=1.558～7.262)是再住院精神分裂症患者服药依从性的独立危险因素(P＜0.05).结论 精神分裂症患者自知力越差,则依从性越差;严重精神疾病风险评估分级越高,依从性越差,因此临床医务人员需重视患者自知力并及时评估严重精神疾病风险等级,将有助于提高患者治疗依从性.