目的:观察中药扶正化痰解毒方对惰性B细胞淋巴瘤病程进展的影响及其可能机制.方法:将诊断为惰性B细胞淋巴瘤的109例患者,随机分为两组.治疗组67例,对照组42例;治疗组予中药扶正化痰解毒方,3个月为1个疗程,对照组予定期随访观察.治疗组47例住院患者每3个月检查1次相关观察指标,连续观察3年.结果:治疗组3年内进入西医干预人数明显少于对照组(P＜0.001);治疗组47例住院患者治疗后中医证候学积分较前明显降低(P＜0.05);治疗组47例住院患者治疗后较治疗前CD4/CD8明显升高(P＜0.05),VEGF、TNF-α明显降低(P＜0.05).结论:扶正化痰解毒方能够有效延缓惰性B细胞淋巴瘤患者进入西医干预阶段,且能够减轻患者的相关临床症状,改善生存质量.

目的 研究盒灸对前列腺电切术后膀胱痉挛患者膀胱痉挛与出血的影响.方法 将72例已行前列腺电切术发生膀胱痉挛的住院病人,按入院顺序随机分为两组,治疗组使用盒灸加常规护理,对照组使用常规护理.实际完成试验72例,其中治疗组34例,对照组38例,均每天盒灸两次,连续盒条3天观察疗效.结果 盒灸护理法在改善前列腺电切术后患者膀胱痉挛及出血情况方面,治疗组优于对照组,相关指标比较差异有显著性(P＜0.05).结论 盒灸是改善患者前列腺电切术后膀胱痉挛及出血情况的一种操作简便、无痛苦、费用低廉、易于推广的方法.

Objective:To research box moxibustion treatments for prostate electric resection of bladder spasm in patients with bladder spasm,pain and complications.Methods:72 cases of our department had been in the prostate transurethral resection of bladder spasm inpatient admission order box moxibustion care plus routine care were randomly divided into two groups,the treatment group and the controlled group using conventional care.Actually completed the trial,72 cases in which treatment group,34 patients in the controlled group of 38 cases.Effects were observed when box moxibustion were done every day and the care lasted for 3 days.Results:Box moxibustion could improve the prostate patients with resection of bladder spasm,pain and bleeding,the effects of the treatment group were better than the controlled group,significant difference related indicators( P <0.05).Conclusions:Box moxibustion care can improve bladder spasm,pain and bleeding in patients with prostate electric resection,and the operation is simple,painless,inexpensive and easy to spread.

Objective To review systematically whether there is enough existing evidence about the curative effect and safety of Chinese Herb Clearing Heat and removing dampness combining with Western Medicine against rheumatoid arthritis(RA) patients in active phase.Methods Searching the Cochrane Controlled Trials Registration(CCTR),Medline,China National Knowledge infrastructure(CNKI),Chinese VIP database,Chinese Biomedical Literature Database(CBM) and WanFang Database of Dissertation,then the studies met the requirements were reviewed by Meta-analysis.Results 13 Chinese RCTs and quasi-RCTs meet the criterion.The results of Meta-analysis indicated:(1)Compared Western Medicine alone,combining Chinese Herb Clearing Heat and removing dampness is better for RA patients in active phase on effective rate,joint pain or tenderness,joint swelling,morning stiffness,hand grip strength,HAQ,ESR,CRP,RF,IgG and reducing the incidence of adverse reactions;(2) But no significant difference was found in the improvement of articular dyskinesia,15 meter walking time,IgA and IgM.Conclusion This study demonstrated that Chinese Herbs Clearing Heat and removing dampness combining with Western Medicine have an advantage over Western Medicine alone in RA patients in active phase.However the poor methodological quality of included studies seriously weakened the validity of the meta-analysis which were needed to further assess by the high quality and large sample sized RCTs.

This study compared the Yin deficiency and blood heat syndrome of idiopathic thrombocytopenic purpura(ITP)in patients with other syndromes,indicating serum transforming growth factor-β1(TGF-βl)levels were significantly different from other syndromes and providing the material basis for therapeutic targets for the further search for Yin deficiency and blood heat syndrome of ITP.

特发性血小板减少性紫癜(ITP)也称免疫性血小板减少性紫癜,是临床上最常见的一种血小板减少性疾病.研究表明,细胞因子对造血细胞的调控起重要作用[1].在众多的细胞因子中,转化生长因子β(TGF-β)属于一组新近发现的调节细胞生长和分化的细胞因子,为了探明其对ITP的影响,研究报告如下.

Objective:To assess the effect of combined treatment of Chinese medicine and western medicine on diabetic nephropathy(DN).Methods:Randomized or semi-randomized controlled trials(RCT or CCT) which compared combined treatment of Chinese medicine and western medicine with western medicine alone were collected.The methodological qualities of included studies were evaluated and meta-analysis was performed.Results:69 Chinese RCTs and 1 CCT were included in this review.All trials were classified as grade C.The results of meta-analysis demonstrated that compared with western medicine alone,combination with Chinese medicine could significantly decrease the urinary albumin excretion rate,the 24-hour urinary albumin excretion,the 24-hour urinary protein excretion,blood urea nitrogen and serum.

Objective To assess the effect of Chinese herbal medicine on hyperglycemia and hyperlipidemia of diabetic nephropathy(DN) . Methods Randomized or semi-randomized controlled trials(RCT or CCT) which compared combined treatment of Chinese medicine and western medicine with western medicine alone were collected.Meta-analysis was performed. Results 56 Chinese RCTs and 1 CCT were included in this review.All trials were classified as grade C.The results of meta-analysis demonstrated that compared with western medicine alone,combination with Chinese medicine could significantly decrease fasting blood glucose(WMD=-0.65,95%CI(-0.90,-0.40) ,P<0.000 01) ,glycosylated hemoglobin(WMD=-0.42,95%CI(-0.71,-0.14) ,P=0.004) ,cholesterol(WMD=-0.91,95%CI(-1.16,-0.66) ,P<0.000 01) and triglyceride(WMD=-0.51,95%CI(-0.68,-0.35) ,P<0.000 01) . Conclusion Chinese herbal medicine showed an encouraging comparative effectiveness on hyperglycemia and hyperlipidemia of DN.But the poor methodological quality of included studies seriously weakened the validity of the meta-analysis.More RCTs with higher qualities are required.

硬皮病是以广泛的胶原增殖和组织纤维化为主要病理特征的全身性自身免疫损害性疾病.以皮肤硬化、雷诺氏现象及关节强直等为主要临床表现,常累及皮肤、关节、消化道、肺、心、肾等组织器官,对患者的身心健康造成严重损伤.

Objective To observe the clinical efficacy of Shudi Pingchan Decoction and western medicine in the treatment of Parkinson's disease(PD).Methods The multicentre,randomized controlled trial was used in this observation.Total 120 subjects were divided into control group and control group,60 cases in each group.Control group was continued to use levodopa while the treatment group was treated with levodopa and Shudi Pingchan Decoction,with a course of 3 months.The UPDRS scale and switching time were measured.Results The total effective rate was 43.33% in the treatment group and 16.67% in the control group,with a striking difference between them(P0.01).In the treatment group,the motor symptoms were obviously relieved,the scores of UPDRS Ⅱand UPDRS Ⅲ were reduced(P0.05,P0.01);the time of turn-off was extended while the time of turn-on was reducedz(P0.05).Conclusion Shudi Pingchan Decoction can help clinical effects and reduce adverse reactions.

目的:观察补肾填髓活血方在慢性特发性血小板减少性紫癜(ITP)治疗中对T细胞亚群的影响。方法:治疗组30例慢性ITP病例,给予补肾填髓活血方(阿胶、仙灵脾、巴戟肉、菟丝子、女贞子、枸杞子、参三七等)治疗3个月,观察治疗前后血小板计数、CD3、CD4、CD8、CD4/CD8水平的变化,并与西药强的松对照组23例进行比较。结果:与治疗前相比,治疗组和对照组均能提高血小板计数(P<0.05),但两组之间没有统计学差异(P>0.05);治疗组CD3、CD4、CD4/CD8有不同程度提高CD8水平有所下降(P<0.05);对照组CD3、CD4/CD8较前提高,CD4、CD8水平降低(P<0.05),两组相比在提高CD3、CD4/CD8,降低CD8水平方面无统计学差异(P>0.05)。结论:补肾填髓活血方治疗慢性ITP的疗效确切,对T细胞亚群免疫功能有调节作用,可能是其发挥治疗作用的机制,尚需进一步深入研究。

Objective To observe the therapeutic effect of the different extracts from Ampelopsi megalophylla on rats with renal hypertension.Methods Reformed Gold-blatt hypertension rat model(G-2K1C)was established.The rats were divided into 6 groups as follows:model group,the ethanol extract group,the ethyl acetate extract group,the petroleum ether extract group,the water extract group and Fufangluobuma tabletⅠgroup.The change of systolic pressure and diastolic pressure were observed.Results The blood pressure of the G-2K1C rats decreased obviously in the ethanol extract group and the ethyl acetate extract group(P0.01);and there was no difference between the above two extract groups and Fufangluobuma tabletⅠgroup.Conclusion The ethanol extract group and the ethyl acetate extract group all possess satisfying therapeutic effects in decreasing the blood pressure.

<正>类风湿性关节炎(Rheumatoid Athritis,RA)是一种以关节和关节周围组织的非感染性炎症为主的全身性自身免疫性疾病,据其临床表现,当属祖国医学"历节"、"顽痹"、"骨痹"等范畴。中医药治疗RA具有一定优

应用电子计算机技术的嗓音声学测试,近十年来临床研究和应用日益广泛,已成为嗓音声学客观检测的重要手段之一。它是一种客观、无创和能提供较准确可比临床资料的嗓音质量评估方法。目前应用的主要参数有基频、振幅、微扰值（频率微扰、振幅微扰）、噪声谱（谐噪比、信噪比、标准化噪声能量）等。现就此方面的研究进展进行综述。

目的研究正常人及慢喉喑(慢性喉炎、声带小结、声带息肉)患者的嗓音声学参数变化,探讨嗓音声学测试在慢喉喑疾病嗓音障碍程度评估及辨证分型中的作用。方法对40例正常嗓音者和90例慢喉喑患者进行嗓音声学检测,同时对慢喉喑患者进行辨证分型,分为肺脾气虚组、肺肾阴虚组及痰凝血瘀组,分析各组的声学特征。结果慢喉喑各证型的基频微扰(jitter)、振幅微扰(shimmer)、标准化噪声能量(NNE)、谐噪比(HNR)及信噪比(SNR)与正常组比较差异均有显著统计学意义。慢喉喑各证型组中,从气虚组到阴虚组再到痰凝血瘀组,jit-ter、shimmer、NNE均呈现升高趋势,而HNR、SNR降低,但各组间比较,部分参数值差异有统计学意义。结论嗓音声学检测有助于慢喉喑各疾病程度的评估,可以为慢喉喑辨证分型提供一定的参考。

Objective:To assess the efficacy of Chinese herbal medicine suPPlementing qi,clearing heat and activating blood circulation in the management of urine Protein in diabetic nePhroPathy. Methods:Search the following database:Medline(1978-2008) ,VIP(1989-2009) ,CBM disc(1990-2009) ,CMA digital Periodicals(1998-2008) and Wanfang full-text database (1984 -2009) . Randomized or semi-randomized controlled trials (RCT) which comPared Chinese herbal medicine suPPlementing qi,clearing heat and activating blood circulation with ACEI or ARB were collected. Two indePendent reviewers evaluated themethodological quality of included studies and meta-analysis was Performed. Results:39 Chinese RCTs were included in this review. All trials were classified as grade C. The results of meta-analysis demonstrated that comPared with ACEI or ARB alone, combination with Chinese herbal medicine suPPlementing qi,clearing heat and activating blood circulation could significantly decrease the urinary albumin excretion rate(WMD =-40. 67,95% CI(58. 65,22. 69) ,P 0. 00001) ,the 24-hour urinary albumin excretion(WMD =-26. 86,95% CI(40. 44,13. 29) ,P = 0. 0001) and the 24-hour urinary Protein excretion (SMD = -0. 70,95%CI(-0. 81,-0. 58) ,P 0. 00001) ; Herbal medicine alone could significantly decreased the 24-hour urinary albumin excretion(WMD =-26. 86,95% CI(40. 44,13. 29) ,P = 0. 0001) and the 24-hour urinary Protein excretion (SMD = -1. 48,95%CI(-2. 27,-0. 70) ,P = 0. 0002) ,but no significant difference in the reduction of the urinary albumin excretion rate(WMD = 0. 59,95% CI(42. 14,43. 31) ,P = 0. 98) . Conclusion:The Poor methodological quality of included studies seriously weakened the validity of the meta-analysis. So the efficacy of Chinese herbal medicine suPPlementing qi,clearing heat and activating blood circulation in the management of urine Protein in diabetic nePhroPathy should be determined by more RCTs of high quality comPared with ACEI or ARB.

Objective To study the chemical constituents from Ampelopsis megalophylla.Methods The constituents were isolated on silica gel,Sephadex LH-20 column chromatography.Their structures were identified by UV,1H-NMR,13C-NMR,HSQC,and HMBC.Results Nine compounds were isolated and eight compounds among them were identified as emodin(Ⅰ),β-sitosterol(Ⅲ),taxifolin(Ⅳ),myricetin(Ⅴ),ampelopsin(Ⅵ),quercetin(Ⅶ),quercetin-3-O-α-L-rhamnoside(Ⅷ),and myricetrin(Ⅸ).Conclusion Compounds Ⅰ,Ⅲ-Ⅴ,Ⅶ-Ⅸ are obtained from this plant for the first time.

OBJECTIVE Acute-kidney-artery hypertensive model rats were used to study on the anti-hypertension function of differently extracted the parts.METHODS Model rats that have been made were given emulsion of differently extracted the parts of Ahpclopig Mega lophgl,then observe and record the changes in blood pressure.RESULTS Blood pressure of model rats that were given the ethyl acetate extracts fell to normal range gradually,and have statistically significant difference with the control group.CONCLUSION The ethyl acetate extracts have the obvious anti-hypertension function.

Objective To establish an HPLC fingerprints of the effective part of Ampelopsis megalophylla Diels et.Gilg for reflecting the internal chemical information and evaluating its quality in a scientific and effective way.Methods HPLC method was applied for the quality assessment of Ampelopsis megalophylla Diels et.Gilg.The preparation of sample,the HPLC column,mobile phase,elution mode(isocratic and gradient) and gradient program were optimized in order to obtain high qualified HPLC profile.The HPLC system consisted of a Waters 600E pump and a 2996 photodiode-array detector(DAD).Data were acquired and processed with the Empower workstation.HPLC analysis was performed on an Agilent TC C18 column(250 mm×4.6 mm,5 μm) with the mixture of acetonitrile and 0.1% phosphoric acid aqueous solution as the mobile phase in gradient mode.The column temperature was set at 30℃,the flow rate was 1.0 ml/min,and the detection wavelength was at 250 nm.Results The HPLC fingerprints of the effective part of Ampelopsis megalophylla Diels et.Gilg showed 10 common peaks in 10 batches of samples collected at different time.By comparison of the retention time and the on-line UV spectra of chemical standards,peak1,5,6,9 and 10 were identified as ampelosin,taxifolin,quercitrin,quercetin and myricetin,respectively.Conclusion The HPLC fingerprint of the effective part of Ampelopsis.megalophylla Diels et.Gilg with high specificity can be used to control its quality.

目的:观察补肾方对难治性原发性血小板减少性紫癜的疗效影响。方法:选取40例病例只给予补肾方,同时设立对照组20例,只给予西药治疗,6个月后观察疗效。结果:与治疗前相比,中药组和西药组均能提高血小板计数和血小板平均体积(P<0.05),而且治疗后两组疗效没有差异(P>0.05)。结论:中药组的疗效与西药组相当,且没有西药的副作用,价格便宜,是治疗难治性ITP的首选药物。