目的 探讨入院时血糖水平与脓毒症患者预后的相关性.方法 选取2016年4月—2021年10月在南通大学附属医院急诊科住院的290例脓毒症患者,根据入院时血糖水平分为正常血糖组(血糖值4.0～7.7 mmol/L)116例、轻度高血糖组(血糖值＞7.7～11.0 mmol/L)95例、严重高血糖组(血糖值＞11.0 mmol/L)79例,并排除了低血糖组.采用限制性立方样条曲线分析血糖水平与28 d死亡率的关系;采用Logistic回归模型分析血糖等级与28 d死亡率的相关性;根据既往是否存在高血压和糖尿病进行亚组分析.结果 290例患者中,28 d内死亡70例(24.1％).与存活组(n=220)比较,死亡组患者年龄更大、序贯器官衰竭评分(SOFA)和急性生理学与慢性健康状况评分系统(APACHE Ⅱ)评分更高,差异有统计学意义(P＜0.05).正常血糖组、轻度高血糖组、严重高血糖组的基线特征资料比较显示,随着高血糖严重程度加剧,高血压和糖尿病的既往患病率更高,差异有统计学意义(P=0.01、P＜0.01),凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)有缩短趋势,差异有统计学意义(P＜0.01);3组28 d死亡率分别为18.1％、22.1％、35.4％,差异有统计学意义(P=0.02).随着血糖水平的增加,患者28 d死亡率的风险升高,二者呈线性关系(非线性检验P=0.856);单因素Logistic回归分析发现,年龄增加、SOFA得分增高、APACHE Ⅱ得分增高、血糖升高程度与28 d死亡率相关(P＜0.05);在多因素回归分析构建的模型1和模型2中,严重高血糖均与28 d死亡率独立相关[OR(95％CI)=2.48(1.25～4.95)、3.38(1.50～7.63)];对既往是否存在高血压和糖尿病进行亚组分析,未发现显著交互作用(P＞0.05).结论 脓毒症患者入院时严重高血糖与28 d死亡风险升高相关,应引起临床医生的重视.

目的:研究E型前列腺素受体2(prostaglandin E receptor 2,EP2)激动剂Butaprost对脓毒症急性肾损伤小鼠的保护作用及其可能机制.方法:40只小鼠随机分为正常组、假手术组、盲肠结扎穿刺(cecum ligation and puncture,CLP)组、CLP+Butaprost组,每组10只.CLP法建立脓毒症小鼠急性肾损伤模型.小鼠死亡时取小鼠肾脏标本并采集小鼠的静脉血.采用全自动血液分析仪检测小鼠血清肌酐(serum creatinine,SCr)及尿素氮(blood urea nitrogen,BUN);HE染色观察肾脏组织病理变化;Western Blot检测肾脏组织CCAAT/增强子结合蛋白同源蛋白(CCAT/enhancer-blinding protein homologous protein,CHOP)、葡萄糖调节蛋白78(glucose-regulated protein 78,GRP78)蛋白表达.结果:与CLP组比较,CPL+Butaprost组小鼠肾脏病理有改善,SCr、BUN降低及CHOP、GRP78蛋白表达减少(P<0.05).结论:Butaprost通过激活EP2调控内质网应激进而延缓肾脏损伤以发挥保护作用.

目的:探讨血栓弹力图(thrombelastography,TEG)对脓毒症患者早期凝血功能和病情严重程度的评估价值.方法:回顾性分析2018年12月—2020年6月入住南通大学附属医院急诊监护病房的脓毒症患者69例,分为脓毒症组(25例)和脓毒性休克组(44例).所有患者均在入院24 h内完成常规凝血功能、血常规、TEG检测、患者病情严重程度评分:序贯器官衰竭评分(sequential organ failure assessment,SOFA)和急性生理学及慢性健康状况评分系统(acute phys-iology and chronic health evaluation scoring systemⅡ,APACHEⅡ)评分.TEG检测指标包括凝血反应时间(R值)、血块生成时间(K值)、血块生成率(α角)、最大宽度值(MA值)、凝血综合指数(CI值)等.根据2016年改良的日本急诊医学学会评分系统(modification of Japanese association for acute medicine score,M-JAAM)将脓毒性休克组分为弥散性血管内凝血(disseminated intravascular coagulation,DIC)组25例、非DIC组19例,比较TEG各项指标在脓毒症组和脓毒性休克组,脓毒性休克DIC组和脓毒性休克非DIC组之间的差异,并分析SOFA评分与TEG各指标的相关性.结果:脓毒性休克组较脓毒症组患者R值、K值延长(F=2.285、2.250,均P<0.05),α角、MA值、CI值减小(F=2.135、2.010、2.060,均P<0.05).脓毒性休克DIC组的R值和K值显著大于非DIC组(F=2.88,4.163,均P<0.05),脓毒性休克DIC组的α角、MA值和CI值显著小于非DIC组(F=4.988、0.577、4.692,均P<0.05).SOFA评分与R值、K值呈明显正相关(r=0.40、0.47,均P<0.05),与α角、MA值、CI值呈明显负相关(r=-0.47、-0.38、-0.46,均P<0.05).结论:TEG具有评估脓毒症患者病情严重程度的价值,可协助诊断脓毒症并发DIC,评估血栓、出血风险,从而指导有效准确地干预治疗,提高抢救成功率,改善预后.

深静脉血栓形成(DVT)是胸腹腔镜食管癌根治术中的严重并发症.术前对DVT相关危险因素和患者状况进行正确评估是预防术中DVT发生的前提,针对高危因素采取综合防护措施是预防DVT发生的关键,通过提前护理干预,可有效降低DVT发生风险,提高患者手术安全性.

目的:探讨重症急性胰腺炎(severe acute pancreatitis,SAP)急性期强化胰岛素治疗与预后的关系.方法:入选自2014年1月—2016年8月明确诊断为SAP在我院住院的患者共96例,在常规禁食、抑酸、抑制胰酶分泌、补液维持内环境平稳及肠外营养支持的基础上,根据血糖目标控制情况进行随机分组,分为强化组48例(目标血糖控制在4.4～6.1 mmol/L)和对照组48例(目标血糖控制在>6.1～11.1 mmol/L),比较两组患者低血糖发生率、病死率、改良Marshall评分动态变化(入院后第1、3、5、7天)、平均住院时间,并随访3个月,根据血糖化血红蛋白水平和糖耐量试验结果,比较两组后遗糖尿病的发生率.结果:两组在低血糖发生率和病死率方面差异无统计学意义.但与对照组相比,强化组改良Marshall评分随治疗时间的推移,下降趋势更明显,在治疗第7天差异有高度统计学意义(P<0.001),平均住院时间显著下降[(17.3±2.3)d vs(22.9±3.8)d,P<0.01].随访3个月,强化组后遗糖尿病的发生率显著降低(4.5％vs 16.2％,P<0.05).结论:强化胰岛素治疗治疗方案尽管不能降低SAP患者的病死率,但可以更快缓解病情,有效缩短住院时间,降低后遗糖尿病的发生风险,且不增加住院期间患者低血糖发生率.

目的：探讨风险因素管理体系对老年糖尿病患者烧伤后创面感染影响。方法收集实施危险因素管理体系前后老年糖尿病烧伤患者的临床病理数据各50例，分别作为对照组和实验组，记录和比较两组患者的创面菌群种类及数量比较，感染持续时间和感染率及其抗生素使用情况（抗生素药物种类和抗生素应用持续时间）、患者的总住院时间、满意度评价等。结果对照组培养阳性患者共37例，总感染率74．0％；实验组培养阳性患者共21例，总感染率42．0％，两组差异显著（P ＝0．024）。对照组患者的相对感染持续时间〔（28．6±3．4）d〕与实验组〔（9．5±3．1）d〕比较显著较长（P＜0．01）；总菌株数存在显著性差异（P＜0．01），但各种病原菌的比例均无统计学意义（ P＞0．05）。对照组患者单一样本平均感染菌株数（72．6±5．4）与实验组患者（31．3±6．1）比较显著增高（P＜0．05）。实验组患者的抗生素药物种类〔（2．3±0．4）种〕与对照组〔（3．1±0．8）种〕比较显著减少（P ＝0．006）；实验组患者的抗生素应用持续时间〔（17．6±1．4）d〕与对照组〔（29．3±2．1）d〕比较显著缩短（P ＝0．034）。通过实施感染危险因素控制管理体系后，对照组和实验组老年糖尿病烧伤患者的出院总满意度有显著性差异（91．6％ vs 94．0％，P ＝0．036）。结论实施老年糖尿病烧伤患者感染风险因素管理控制体系，能有效降低患者烧伤创面菌株种类和数目，有效降低患者感染事件和感染率，从而减少抗生素使用种类和使用时间，大大提高了医疗质量。

Objective To investigate the effect of continuous renal replacement therapy (CRRT) combined with ulinastatin on inflammatory factors,hemodynamic parameters and prognosis in patients with bum sepsis.Methods Thirty patients with bum sepsis enrolled from January 2014 to June 2017 in Affiliated Hospital of Nantong University were divided into observation group and control group,with 15 cases in each group.The control group was treated with CRRT;the observation group was treated with CRRT and intravenous administration of ulinastatin.Infection indexes,inflammatory factors and hemodynamic parameters were tested before and 1,3,5,7 d after treatment.Scores of acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and multiple organ dysfunction syndrome (MODS) were recorded to evaluated the severity of sepsis.The mortality rate was analyzed.Results Levels of white blood cell count,procalcitonin (PCT) and C-reactive protein (CRP) in observation group were significantly lower than those in control group 3,5 d after treatment[3 d:(15.5 ± 1.7) ×109/L vs (18.6 ± 3.6) × 109/L,(10.3 ± 2.3) mg/L vs (13.3 ± 1.7) mg/L,(26 ± 13) mg/L vs (32 ± 10) mg/L;5 d:(13.3±2.4) ×109/L vs (15.5±2.2) × 109/L,(8.2±l.6)mg/L vs (10.2±2.2)mg/L,(20±8)mg/L vs (30 ± 8) mg/L] (P ＜ 0.05);PCT and CRP in observation group were significantly lower than those in control group7 daftertreatment[(4.7±l.7)mg/L vs (6.7 ±l.9)mg/L,(lO±8)mg/L vs (13 ±6)mg/L](P＜0.05).The level of tumor necrosis factor-α in observation group was significantly lower than that in control group 3,5 d after treatment [(56 ± 13) μg/L vs (62 ± 11) μg/L,(47 ± 10) μg/L vs (55 ± 13) μg/L] (P ＜ 0.05);interleukin-1 β,-6,-10 in observation group were significantly lower than those in control group 5 d after treatment [(59 ± 14) μg/L vs (67± 11) μg/L,(41 ±8) μg/L vs (46 ± 8) μg/L,(31.7 ±4.3) μg/L vs (33.6 ± 3.4) μg/L](P ＜ 0.05).The oxygenation index in observation group was significantly higher and the level of blood lactic acid was significantly lower than those in control group 3,5,7 d after treatment(P ＜ 0.05).Scores of APACHE Ⅱ and MODS significantly decreased 5,7 d after treatment and there were significant differences between observation group and control group[5 d:(14 ±4) points vs (18 ±4) points,(7.7 ± 3.4) points vs (10.7 ± 1.8) points;7 d:(12 ± 6) points vs (17 ± 5) points,(6.5 ± 3.2) points vs (9.8 ± 3.6) points] (P ＜ 0.05).The death rate in observation group was lower than that in control group[20.0％ (3/15) vs 33.3％ (5/15)] but the difference was not significant (P ＞ 0.05).Conclusion CRRT combined with ulinastatin treating burn sepsis can effectively improve hemodynamic status,lower inflammatory factors and improve the prognosis.

目的 探索血浆D-二聚休水平能否作为反映急性肺血栓栓塞症(APTE)长程抗凝治疗后血栓变化情况的有效监测指标.方法 采用前瞻性观察性研究方法,选择2010年7月至2014年4月南通大学附属医院经D-二聚体水平及同步CT血管造影(CTPA)确诊的62例APTE患者.所有患者均进行长程抗凝治疗,观察血浆D-二聚体变化,随访终点时患者肺动脉血栓变化以CTPA复查结果作为最终依据,并将其分为血栓复发组(5例)与未复发组(57例).将随访终点的D-二聚体检测结果与CTPA结果进行Kappa分析,以判断两种方法确诊APTE的一致性.结果 经规范抗凝治疗后,APTE患者血浆D-二聚体均逐渐下降;随访终点时,复发组血浆D-二聚体显著高于未复发组,差异有统计学意义(μg/L:958.4± 213.1比209.9±122.0,P＜0.05);对症状无反复、D-二聚体持续阴性者,复查CTPA也提示肺动脉血栓消失或趋于慢性机化;而症状反复、D-二聚体水平波动增高者,复查CTPA则证实肺动脉血栓活动复发;Kappa分析提示两种检测方法有高度一致性,差异有统计学意义(Kappa=0.621,P=0.000).结论 动态监测血浆D-二聚体可替代CTPA作为APTE抗凝治疗效果的随访指标,具有良好的医疗经济学效益,值得推广.

本研究为观察穿心莲内酯(AD)对乙醇诱导肝细胞氧化应激损伤的保护作用,体外培养肝细胞L-02,用不同浓度(0～30μmol/L) AD孵育1h,随后加入100 mmol/L乙醇作用24 h.ELISA测定AD处理前后细胞培养上清中谷丙转氨酶(ALT)和谷草转氨酶(AST)的含量;比色法检测丙二醛(MDA)和谷胱氨肽(GSH)的变化;荧光探针DCFH2-DA检测胞内活性氧(ROS)的产生;Western blotting和分析血红素氧合酶-1(HO-1)mRNA和蛋白的表达.电泳迁移率实验(EMSA)检测核转录因子Nrf2的DNA结合活性.结果表明,100 mmol/L乙醇处理肝细胞后,可在不影响L-02活性的情况下显著增加培养上清中ALT和AST的含量,而AD预处理后可抑制ALT、AST、MDA和ROS的增加以及上调胞内GSH的水平.此外,Western blotting和实时定量PCR结果也证实乙醇可降低肝细胞内源性HO-1的表达,而AD预处理后可增强转录因子Nrf2的活性并进一步上调HO-1的表达水平.AD可能通过激活Nrf2上调HO-1表达而发挥对乙醇所致肝细胞损伤的保护作用.

目的 观察沙利度胺对原发性肝癌( HCC)患者介入治疗后T淋巴细胞和红细胞免疫功能的影响. 方法将100例中晚期HCC患者随机分为观察组及对照组各50例. 两组均采用改良Seldinger法行经皮导管动脉化疗栓塞术,观察组介入治疗1周后给予沙利度胺口服100~200 mg,1次/d,时间至少3个月;对照组介入治疗后未予沙利度胺口服,介入治疗1、13周后采用微量全血直接免疫荧光法检测T淋巴细胞,采用受体黏附法检测红细胞免疫功能变化. 结果 观察组介入治疗13周后总T细胞( CD3+)、辅助/诱导T淋巴细胞( CD4+)、CD4+/CD8+和肿瘤红细胞花环(DTER)、红细胞C3b受体花环(RBC-C3bRR)显著高于同组介入治疗1周后及对照组介入治疗13周后(P均<0.05),红细胞免疫复合物花环(RBC-ICR)显著低于同组介入治疗1周后及对照组介入治疗13周后(P均<0 .05 ). 结论 沙利度胺具有正向调节HCC患者T淋巴细胞及红细胞免疫功能的作用,可应用于HCC介入治疗后的细胞免疫调节的辅助治疗.

Objective To evaluate in vitro biological activities of paclitaxel nanoparticles with dual ligands. Meth-ods The cells were incubated with H-F-P NPs,H-Tat-P NPs,or H-F-Tat-P NPs,and then evaluated by using flow cytometry. Then the cells were incubated with H-F-Tat-P NPs,and evaluated by using confocal laser scanning microscopy. Results Quantitative analysis of cellular uptake of NPs by flow cytometry showed the extend of celluar uptake for A549 cell lines was:H-F-Tat-P NPs > H-Tat-P NPs > H-F-P NPs. For MDA-MB-231 cells:H-F-Tat-P NPs >H-F-P NPs> H-Tat-P NPs. Quali-tative analysis of cellular uptake of H-F-Tat-P NPs by confocal laser scanning microscopy showed the fluorescent signal of NPs in MDA-MB-231 cells was higher than that of A549 cells under the same conditions. Conclusion The strategy on nano-medicine with dual ligands can enhance the cellular uptake of drug thereby improve its chemotherapeutic efficiency. The nano-particle system could be used as a promising cancer cell specific delivery system for further investigation.

目的 评价多西他赛联合顺铂(DP)方案诱导化疗后三维适形放疗同步化疗对局部晚期喉癌的疗效.方法 局部晚期喉癌患者57例随机分为两组:A组28例,采用DP方案诱导化疗3个周期后,予三维适形放疗同步化疗;B组29例,单纯行三维适形放疗.比较两组近期有效率、2年局部控制率、2年生存率和不良反应.结果 A组近期有效率、2年局部控制率、生活质量改善率、白细胞减少发生率和恶心呕吐发生率均高于B组(82.14％ vs.55.17％、64.29％ vs.37.93％、82.14％ vs.51.72％、92.86％vs.37.93％和75.00％vs.48.28％)(P＜0.05).A组2年总生存率稍高于B组(82.14％vs.68.97％)(P＞0.05).结论 DP方案诱导化疗后三维适形放疗同步化疗治疗局部晚期喉癌能提高近期疗效及局部控制率,可改善患者生活质量.

Objective To identify factors associated with ST-segment myocardial infarction (STEMI) patients who experienced no chest pain, and to improve recognition of STEMI patients without presentation of chest pain in the emergency room (ER). Methods A retrospective study was conducted in ER of the Affiliated Hospital of Nantong University from 2010 to 2014. Clinical characteristics and presentations were recorded in patients diagnosed with STEMI in the ER. Patients with and without chest pain were compared according to clinical features. Results Among the 228 STEMI patients, 14.04%of patients had no chest pain presentation in the ER. Syncope, epigastric pain, and dyspnea accounted for more than 70% of symptoms in STEMI patients without chest pain. Diabetes mellitus (DM), cerebrovascular accident (CVA), and old age were risk factors for STEMI patients without chest pain. Conclusions DM, CVA, and elderly patients are more likely to be without chest pain when STEMI occurred.

Objective To observe the curative effect and adverse reactions of three-dimensional conformal radiotherapy and GemOx chemotherapy for locally adanced pancreatic cancer .Methods 24 patients both confirmed by pathology or clinical diagnosis as locally adanced pancreatic cancer received three-dimensional conformal radiotherapy ,plan the 6 MV-X line doses of DT 60~70 Gy,2~2.5 Gy/time,and 2 cycles of GemOx chemotherapy ( gemcitabine 1000 mg/m2 ,d1,d8;oxaliplatin 130 mg/m2,d1),maintain 2 cycles of GemOx chemotherapy after radiotherapy ,each cycle was 21 days,clinical curative effect,benefit re-action and adverse reactions were observed .Results Among 24 patients,there were complete remission 1 case (4.2%),partial remission 10 cases(41.6%),stable 12 cases (50.0%),progression 1 case (4.2%),effective rate was 45.8%;6-month surviv-al rate was 87.5%(21/24),12-month survival rate was 58.3%(14/24),24-month survival rate was 12.5%(3/24),the medi-an survival time was 11.8 months;CBR assessment:without jaundice drainage in 3 cases,jaundice subsidised after treatment in 2 cases (66.7%),21 cases of abdominal pain in the back before treatment (87.5%),after treatment the effective rate was 90.5%(19/21);Patients'general Karnofsky score increased by 20 points in 18 cases,which was above 75.0%;Adverse reaction were nausea、vomiting in 13 cases (54.2%),leukocytopenia 16 cases (66.7%),thrombocytopenia 9 cases degree (37.5%),of which Ⅰdegree and Ⅱdegree were respectively 10 cases(41.7%),12 cases(50.0%),5 cases(20.8%);Ⅲ degree were re-spectively 3 cases (12.5%),4 (16.7%),3 cases (12.5%);Ⅳdegree thrombocytopenia 1 case(4.2%).Conclusion Three-dimensional conformal radiotherapy combined GemOx for locally adanced pancreatic cancer has good relieve symptoms and local control effect ,it can improve survival time and the quality of life of patients with tolerable adverse reactions ,it is worthy of clinical popularization .

目的：探讨沙利度胺联合局部放疗及唑来膦酸治疗原发性肝癌（ PHC）骨转移的近期疗效与安全性。方法将PHC骨转移患者61例随机分为观察组33例和对照组28例。两组均采用局部放疗联合唑来膦酸治疗，观察组加服沙利度胺。检测两组治疗前后血清VEGF、AFP水平，比较两组疼痛缓解率和生活质量（ KPS评分法）。结果观察组和对照组疼痛缓解率分别为90．91％、75．00％；KPS评分改善率分别为87．88％、64．28％，两组比较均有统计学差异（P均＜0．05）。观察组治疗后血清VEGF、AFP水平较治疗前显著下降（P均＜0．05）；对照组无明显变化，两组比较均有统计学差异（P均＜0．05）。观察组的毒副反应主要有口干、皮疹、便秘及嗜睡，较对照组稍增加，均可耐受。结论沙利度胺联合局部放疗及唑来膦酸治疗PHC骨转移能够缓解疼痛，提高患者的生活质量，降低血清VEGF、AFP水平，且毒副反应轻。

目的：通过对急性亚硝酸盐中毒的分析，了解心肌肌钙蛋白I(cardiac troponin I，cTnI)与病情严重度的关系。方法：对我院近1年来急诊救治的58例亚硝酸盐中毒患者进行回顾性分析，根据病情分为轻、中、重3组，对比3组间cTnI的阳性率。结果：58例亚硝酸盐中毒患者均出现明显紫绀，经正规治疗后痊愈出院，其中46例有明确接触病史，余12例未能明确接触史；轻度中毒组28例，中度中毒组18例，重度中毒组12例，3组间cTnI阳性率差异有统计学意义。结论：急诊接诊突发不明原因紫绀需考虑亚硝酸盐中毒，重度中毒患者需注意检查cTnI，以便早期发现心肌损害。

Objective To investigate the possible mechanism of Nrf2 in sepsis development and its effect in the septic acute liver injury,and derive the effect of curcumin on Nrf2 expression,which provide theoretical basis for clinical prevention and treatment of sepsis.Methods Divided putting 72 male Sprague-Dawley rats into 3 groups:control group,experimental group and intervention group.After operation,3 groups were further divided into subgroups 6 hours later,12 hours later,24 hours later and 48 hours later respectively.The septic rats model with acute liver injury was reproduced by method of cecal ligation and puncture(CLP).The experimental group and the intervention group took CLP.The rats in the intervention group were rejected with curcumin in the abdomen at a dosage of 100 mg/kg an hour after operation.Detected the expression of Nrf2 in the livers of each group used Western blot and measure alanine aminotransferase(ALT) in serum by drawing the rats′ heart blood;observed the pathological changes in the liver with HE coloration.Results ALT:the values of ALT in the experimental group was significantly increased compared with the control group(P<0.05);while in the intervention group,it was markedly improved compared with the experimental group(P<0.05).The expression of Nrf2:Nrf2 exists in control group rat′s hepatic tissue.In the experimental group,it was progressively increased since the 6 h time point and decreased after the 12 h time point which shown significant decreased compared with the control group(P<0.05).In the intervention group,it was gradually increased since the 6 h time point and decreased after the 24 h time point which was obviously higher than the experimental group(P<0.05).Pathological changes:There was no obvious abnormalities in the control group rats′ liver structure,while a lot of inflammatory cells gather and liver cells swell in the experimental group.It was obvious improved after curcumin intervention.Conclusion As Nrf2 is generally lower in the experimental group than in the comparative group,it shows that Nrf2 directly participates in the occurrence and development of sepsis,while severe infection blow damages the endogenou s protection system.Decreased activity of Nrf2 causes ignificantly inhibition of anti-oxidative stress and natural immune response,which may exacerbate acute liver injury by oxidative stress in sepsis.In case of sepsis,curcumin may increase the level of Nrf2 and the antioxidant enzyme′s activity in the hepatic tissues,enhancing the general antioxidant ability and alleviating the oxidative stress which points out that curcumin prevents the septic acute liver injury.

>手术是治疗食管癌的首选方法。胸中段以上食管癌的手术方式现以食管次全切除,颈部食管与胃吻合重建术为首选,即三切口食管癌根治术。其优点是切除病变完全,清除淋巴组织彻底。我院2007年1月至2009年12月为13例上胸段食管癌患者实施了三切口食管癌根治术,取得了良好的效果,现将术中护理配合报道如下。

<正>随着百草枯(paraquat,PQ)在农业生产中的广泛应用,百草枯中毒已成为继有机磷农药中毒之后的第2位农药中毒。因百草枯中毒缺乏特效解毒剂,中毒后临床疗效仍不容乐观。我院2004年1月～2007年1月开展血液灌流治疗18例百草枯中毒患者,现报告如下。