解析与舱门及其密封件形变相关的适航规章和条款,研究确定与形变相关的主要适航要求.构建基于SolidWorks的舱门及其密封件形变分析模型,开展极高低温、水平突风及其组合条件下舱门及其密封件形变的详细分析,提出基于仿真的舱门及其密封件形变适航符合性验证流程.开展基于虚力原理的舱门挡块部位的形变分析,并与仿真进行了比较研究.结果 表明,讨论的舱门及其密封件形变仿真方法和适航符合性验证流程是合理可行的.

[目的/意义]在地方保护主义的背景下,研究了不同碳限额与交易机制对低碳技术投资决策的影响,以期识别电力供应链企业投资低碳技术的边界.[设计/方法]构建了由发电商和售电商组建的二级电力供应链,采用逆向归纳法,求得不同模型下的均衡解,对均衡解展开敏感性以及比较分析.[结论/发现]当单位碳配额较大时,基准法下的低碳投资水平、批发电价和售电商以及外地发电商的利润均大于祖父法下相应的均衡解;同时,受到地方保护的本地发电商的利润在基准法和祖父法下均大于外地发电商的利润;此外,电力需求量、批发电价和售电商以及外地发电商的利润在基准法和祖父法下都分别随着地方保护力度、单位碳排放量和低碳技术投资成本系数的增加而减少.

[目的/意义]针对可再生能源配额制("配额制")和碳税对可再生能源投资量影响的问题,构建了由发电商和售电商组成的电力供应链模型,考虑了可再生能源间歇性的特征,识别了配额制和碳税政策对可再生能源投资决策的影响.[设计/方法]基于博弈理论框架,识别了可再生能源比例和投资成本系数对均衡解的影响,比较不同政策的均衡解,最后提出建议.[结论/发现]当可再生能源比例较小时,配额制政策将投资更多的可再生能源和生产更多的电力需求量,而当可再生能源比例较高时,碳税政策将投资更多的可再生能源和生产更多的电力需求量;随着可再生能源比例的增加,可再生能源投资量和电力需求量均减少;随着可再生能源投资成本系数的增加,可再生能源投资量和电力需求量均减少.

目的:探讨miR-30d拮抗剂(antagomir-30d)正性调控大鼠骨髓基质干细胞(BMSCs)的成骨分化作用并确认转染的最佳浓度.方法:BMSCs培养并分组,分为不同浓度的antagomir-30d(antagomir-30d组)、阴性对照(NC组)和未做转染的BMSCs(空白组);将不同浓度的antagomir-30d及其NC转染至BMSCs后进行成骨诱导.通过RT-PCR技术进行比较,测定成骨基因碱性磷酸酶(ALP)、骨钙素(OC)、Runt相关转录因子2(RUNX2)的mRNA的表达情况,并确定最佳转染浓度及其转染效率.通过ALP染色验证antagomir-30d对成骨分化的调控作用.结果:RT-PCR结果表明,antagomir-30d体外可以促进BMSCs的成骨分化.不同浓度antagomir-30d组的成骨基因表达量随浓度变化而改变,当antagomir-30d转染浓度为150 nmol/L时,ALP、OC、RUNX2的mRNA水平均显著高于空白组和NC组(P<0.05).Antagomir-30d的转染最佳浓度为150 nmol/L,此时ALP染色结果显示其活性最高,成骨分化作用好.结论:Antagomir-30d体外正性调控BMSCs的成骨分化,其转染至BMSCs的最佳浓度为150 nmol/L.

[目的]研究不同棉花品种在新疆塔里木棉区的养分积累量及产量特性.[方法]设置3种基肥用量,采用两因素裂区试验设计,比较6个棉花品种在3种基肥设置下养分积累差异及产量影响.[结果]6个棉花品种中新陆中55号品种的氮素利用率最高(36.11％),具有较高的氮素吸收能力.新陆中22号、新陆中55号、锦棉Z1112品种的磷积累量显著高于新陆中82号、新陆早74号、新陆早77号品种,磷肥利用效率表现为新陆早77号>新陆中22号>新陆中82号>新陆中55号>锦棉Z1112>新陆早74号.新陆中22号、新陆中55号、新陆中82号、锦棉Z1112、新陆早77号品种的钾含量显著高于新陆早74号品种,钾肥利用效率表现为新陆中55号和新陆中82号较高,新陆中22号品种最低,新陆中55号和新陆中82号品种具有较高的钾素吸收能力;锦棉Z1112、新陆早77号品种的单株铃数显著高于新陆中22号、新陆中55号品种,新陆中22号品种的单铃重显著高于其他5个品种.新陆中22号、锦棉Z1112品种的衣分要显著高于新陆中55号、新陆中82号、新陆早77号品种,新陆早74号品种籽棉产量和皮棉产量均显著低于其他品种.[结论]不施基肥处理棉花株养分吸收积累量少、产量偏低.基肥全施处理下产量最高,基肥半施处理下,基肥施用量减少50％,棉花平均产量减少9％,其中新陆中22号品种和新陆中55号品种的减产最少,为5％和1％.

文章对地铁车辆段上盖物业开发进行了简要介绍,以无锡地铁三号线新梅车辆段上盖物业开发设计为例,分析了地铁车辆段上盖物业开发对工艺设计的影响,重点研究了车辆段上盖开发后设计规模、新车装卸场地、检修库喷漆吹扫作业、检修工艺流线、工艺设备等的调整,为后续车辆段上盖物业开发提供参考.

随着全自动无人驾驶技术的不断进步和完善,城市轨道交通全自动无人驾驶技术日趋成熟,全自动无人驾驶地铁车辆已成为城市轨道交通发展过程中备受关注的焦点.文章介绍了全自动无人驾驶技术的研究背景,简要阐述了自动化驾驶等级的分类,对全自动无人驾驶地铁车辆与传统车辆进行了对比,重点研究分析了全自动无人驾驶车辆的功能及优势.

保持水肥、提高水肥利用效率是我国,特别是西北地区土地利用过程中亟待解决的问题.环境功能材料的应用是农业生产和环境治理中水肥保持的新途径.目前对于不同环境功能材料应用效果的综合定量评价仍难以实现,阻碍了环境功能材料的推广及应用.本研究引入层次分析-模糊综合评价法,以土柱淋溶试验结果为例,对一种环境材料配方的保水性、保肥性及经济性进行综合评价.结果发现:当该复合材料中保水剂、沸石、腐殖酸的配比关系为1∶10∶1时,综合效果最好.配比方式最优的复合材料对水分的最优保持效果为空白对照的1.22倍,对氨态氮、硝态氮和尿素态氮的最优保持效果分别是空白对照的1.2、4.12和1.19倍.实验结果为环境功能材料的筛选及综合评价提供了一种行之有效的方法.

对超高层办公建筑空调通风系统设计的影响因素进行了分析,得出超高层建筑的建筑高度对建筑围护结构冷负荷的影响较小,对空调水系统分区影响较大,高区风压的特性对空调通风系统进排风影响较大的结论.

Objective To investigate the relationship between interleukin (IL)-28B gene polymorphisms (rs12979860 and rs8099917) and treatment response in patients with chronic hepatitis C in China.Methods Taqman probes single nucleotide polymorphism genotyping methods were used to detect the genotypes of rs12979860 (C/T) and rs8099917 (T/G) located at IL-28B gene in 105 included patients.The patients were treated with standard doses of pegylated interferon plus ribavirin and were followed up regularly for therapeutic response and adverse reaction.The relationship between IL-28B gene polymorphism and antiviral treatment response of patients were analyzed.Categorical data were analyzed using Pearson chi-square test or Fisher exact test.Results Totally 105 cases were included in our study and 2 cases lost to follow-up because of moving away.Eight-one cases (78.6%) of the remaining 103 patients were CC/TT genotype (CC/TT group) at rs12979860 and rs8099917, 19 cases (18.4%) were CT/TG (CT/TG group) and 3 cases (2.9%)were TT/TG (TT/TG group).No other genotypes were detected and linkage disequilibrium was discovered at the two polymorphism loci (r2=0.11).After 4 weeks of treatment, 35 cases (43.2%) in CC/TT group, 3 cases (15.8%) in CT/TG group and non in TT/TG group achieved rapid virological response (RVR).There were statistically significant differences among three groups (P=0.033).After 12 weeks of treatment, 45 cases (55.6%) in CC/TT group, 6 cases (31.6%) in CT/TG group and none in TT/TG group achieved early virological response (EVR).There were statistically significant differences among three groups (P=0.025).At the end of the treatment, 68 cases (83.9%) in CC/TT group, 10 cases (52.6%) in CT/TG group and only 1 case (33.3%) in TT/TG group achieved end-of-treatment response (ETR).There were significant statistical differences among the three groups (P=0.003).After 24 weeks of follow-up, 62 cases (76.5%) in CC/TT group, 9 cases (47.4%) in CT/TG group and 1 case (33.3%) in TT/TG group achieved sustained virological response (SVR).There were statistically significant differences among the three groups (P=0.014).One hundred and one cases in CC/TT group developed adverse events, among them 19 cases needed clinical treatment.There were 43 cases in CT/TG group developed adverse events and 9 cases needed treatment.Seven cases in TT/TG group developed adverse events and only 1 case needed treatment.There were no statistically significant difference among three groups (χ2=0.139,P>0.05).Conclusions The genotype of rs12979860 (C/T) and rs8099917 (T/G) at IL-28B gene could affect the treatment response in patients with chronic hepatitis C.RVR and SVR are higher in patients with genotype CC/TT, which might help to guide HCV treatment.

教学思考 阮昊 十年展正好是我教学六年,大三和大五各三年,对教学的思考很多,拎出一条有趣的线进行一个梳理:教学的本质是一种转化率;关于转化率有三种变量,初始值,转化过程和最终结果. A.初始值: 初始值是定义一个区间,在这个区间内任由学.生发挥,其初始点由他的兴趣爱好、成长经历、之前的教学决定,对于初始值好坏的判断应该在那个区间的设定上:我经历了一个由窄区间到形似宽泛但实质狭窄再到相对宽泛的教学经验的成.长.

互联网、物联网等各种网络构成的信息化社会给我们的生活带来了巨大的便利,同时带来了信息的极大丰富,让我们不可避免的进入大数据(Big Data)时代.大数据是运营商的核心资产,合理的开发利用对运营商的运维和营销有着重要意义.文章主要针对大数据在运营商运维工作中新型应用及价值进行探讨,给后续网络运维发展提供借鉴和参考.

目的:评价开窗减压术及改良间隙保持器对儿童大型含牙囊肿的治疗效果.方法:对11例大型含牙囊肿进行开窗减压术,囊液持续引流,;囊腔内碘仿纱条填塞,1周后佩改良间隙保持.随访6～24个月.结果:11例囊肿基本消失,新骨形成.1例患者需额外的正畸治疗.囊腔内的牙全部萌出或明显萌出趋势.所有患者囊肿未有复发.结论:开窗减压术合并改良间隙保持器是一种安全、可靠、效果确实的治疗儿童大型含牙囊肿的方法.不仅恢复患者的美观及功能,还能帮助儿童因失牙引起的心理问题.

目的 探讨游泳运动对大鼠血管抗衰老的影响.方法 30只健康雄性SD大鼠(180～220g)随机分为3组:溶剂对照组(n=10),D-半乳糖组(n=10)和有氧运动+D-半乳糖组(运动组,n=10).D-半乳糖组和运动组大鼠每日颈部皮下注射D-半乳糖(125mg/kg),溶剂对照组大鼠每日颈部皮下注射同体积生理盐水,且运动组大鼠每日进行60 min的无负重游泳运动训练,持续8周.以血浆总一氧化氮合成酶(T-NOS)活力,一氧化氮(NO),内皮素(ET)和NO/ET平衡建立血管衰老指标评价体系,并测量主动脉组织超氧化物歧化酶、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)和丙二醛(MDA)含量.结果 与溶剂对照组相比,D-半乳糖组大鼠主动脉MDA和血浆ET含量显著升高,而GSH-Px、SOD活力、血浆NO含量和NO/ET比值显著下降.与D-半乳糖组相比,运动组大鼠主动脉MDA含量和T-NOS活力显著下降,GSH-Px、SOD、T-NOS活力、NO含量和NO/ET比值显著升高(P＜0.05),且与对照组相比上述各项指标无显著差异.结论 D-半乳糖皮下注射可诱导大鼠主动脉脂质过氧化反应,血浆NO/ET失衡;适宜的有氧运动能显著增加大鼠血管的抗氧化能力,减少脂质过氧化反应,改善NO/ET失衡,预防血管衰老.

Objective To analyze the influence factors of liver inflammation activity and fibrosis of patients with chronic hepatitis B (CHB) infection.Methods A total of 971 patients with chronic hapatitis B virus (HBV) infection,who underwent liver biopsy and routine laboratory testing,such as biochemical tests,blood routine examination,HBV DNA and serum hepatitis markers,were recruited.Categorical data were analyzed by Chi-square test.Quantitative data among three groups were compared by one-way analysis of variance.Quantitative data between two groups were compared by Student-t test,Spearman correlation analysis and multiple regression analysis.Results Nine hundred and seventy-one patients were divided into three groups including group A (more than three continuous normal alanine aminotransferase [ALT] within a year,n=332),group B (first elevated ALT,n=341) and group C (more than two or more elevated ALT within six months,n=298).The male patients in three groups were 47.9 ％,74.2 ％ and 73.8％,respectively,with statistical significance (x2 =64.778,P＜0.01).Hepatitis B e antigen (HBeAg)-positive patients in groups A,B and C were 161 (48.5％),234(69.0％) and 176(59.1％),respectively.The difference was statistically significant in three groups (x2 =28.325,P＜0.01).The proportions of patients with G≥2 in three groups were 36.4％,56.9％ and 51.3％,respectively (x2 =29.868,P＜0.01) ; and those of S≥2 were 25.3 ％,35.5 ％ and 35.9 ％,respectively (x2 =10.807,P=0.005).The proportions of patients with G≥2 and (or) S≥2 in three groups were 137(41.3％),208 (61.0％) and 164(55.0％),respectively.The differences were significant among three groups (x2=22.235,P＜0.01).Group A was divided into subgroup A1 (ALT＜30 U/L) with 229 cases and subgroup A2 (ALT≥30 U/L) with 103 cases.Differences of proportions of male,patients with HBeAg positivity and G≥2 and (or) S≥2 were statistically significant between sub groups A1 and A2 (all P＜0.05).The Spearman correlation analysis and Logistic regression analysis of group A showed that age older than 35 years,ALT≥30 U/L,aspartate aminotransferase (AST)≥25 U/L,HBeAg-positive and platelet counts were associated with significant pathological changes (all P＜0.05).Age (OR=2.012,95％CI:1.196-3.383),HBeAg-positive (OR=2.188,95％CI:1.339-3.584) and AST (OR=2.312,95％CI:1.390-3.846) were independent predictors for significant liver pathological changes.Conclusions The proportion of significant liver pathological changes in the patients with first elevated ALT is similar with that in patients with repeatedly ALT elevated.Thus,early antiviral treatment is recommended in those patients with first elevated ALT.Age≥35 years,HBeAg-positive and AST≥25 U/L are independent predictors for significant liver pathological changes of chronic HBV infected patients with ALT persistently normal.Therefore,for patients who meet the above conditions,early antiviral treatment should be initiated.

Myanmar block D located in the midwest of the Irrawaddy basin,adjacent to Letpanto field,has a certain prospect of oil.There are many different views on provenance of sedimentary among previous study results.Our aims are to make clear the direction and type of the Palaeogene provenance of the block D and the Periheral in the Irrawaddy basin,then to guide the research on facies and the oil and gas exploration by the analytical method of identification of gravel composition,statistical analysis&nbsp;of sandstone fragment components and the analysis of sedimentary geochemistry.The analysis results of patrtical granularity of the gravels,obtained by optical microsope,suggest that there could be one provenance which is the east of the Irrawaddy basin.The rock source of the Palaeocene was consisted of intermediate and acidic rock,but the Eocene provenance came from epimetamorphic and intermediate-basic rock.The analysis of sand detrital composition statistics revealed that provenance of Paleogene strata was derived from the mixed source,contained recycled orogen and the transitional,dissected and undissected arc.The major element,rare-earth element (REE),trace element geochemical analyses show that tectonic settings are all belong to the continental arc and active continental margin and provenances have andesite characteristic.Conbined with previous analysis,it is concluded that the Palaeogene provenance has certain inheritance and similarity.Provenances were mainly from the chain-like island arc in the basin and the highlands of the Shan Plateau in the eastern of basin.The hypothesis that sediments were directly derived from the Himalayan orogen through the northern of the Irrawaddy basin has been denied by the analysis results.It could be that sediments were provided through Irrawaddy River from the east of the basin into the sedimentary province.

Objective To evaluate the effect of Eucommia on hyperlipidemia and related indexes in rats, and provide animal data useful for the clinical experimental studies on hyperlipidemia.Methods Seventy-two healthy male SD rats were used in this study.One group of 12 rats fed with normal diet was chosen as normal control group, and other 60 rats were fed with high fat diet for two weeks to generate rat models of hyperlipidemia.48 of the hyperlipidemic model rats were taken and divided randomly into 4 groups, including model group, high dose Eucommia, moderate dose Eucommia, and low dose Eucommia groups.The last three groups were gavaged different dose of Eucommia, respectively.Druing this period, the other groups except the normal control group were fed with high fat diet continuously.The levels of serum TC,&nbsp;TG, LDL-C, and HDL-C of rats were measured on day 30 and 45.Results The serum levels of TC and LDL-C of the rats in the model group were obviously higher than those in the normal control group.The rat models of hyperlipidemia were established successfully.The three dose groups had a tendency of lowing blood lipid after 30 days.At 45 days, the levels of serum TC and LDL-C in the low and high dose groups were lower than those in the model group (P<0.01, P<0.05), (P<0.01, P<0.01).TG in the high, moderate and low dose groups were lower than that in the model group (P<0.01, P<0.01, P<0.01), but the level of the serum HDL-C was not significantly lower than that in the model group (P>0.05, P>0.05, P>0.05).Conclusions Eucommia in a dose of 0.43 g/kg, 0.86 g/kg and 1.71 g/kg administered for 30 days have a tendency to reduce the level of serum TC, TG, and LDL-C.When Eucommia is administered in a dose of 0.43 g/kg, 1.71g/kg and 3.42 g/kg for 45 days, it shows an adjuvant hypolipidemic effect.

本文简单介绍了第三代移动通信系统TD-SCDMA的六种关键技术：TDD技术、智能天线技术、联合检测技术、动态信道分配、接力切换技术和功率控制技术的概念、作用、原理，着重分析了智能天线+联合检测技术对TD-SCDMA系统所起到的巨大意义。

Objective To prepare lianzhang microemulsion and investigate its physicochemical properties. Methods The formulation was optimized with the pseudo-ternary phase diagrams drawn in a titration method. The process parameters were screened by a single factor test, and the physical and chemical properties of the microemulsion were preliminarily studied. Results The formulation of lianzhang microemulsion was as follows:copts root extracts:polygonum cuspidatum extractstea oilEL35 propylene glycolwater as 11. 417721. The microemulsion was obtained with mean diameter of 30. 9 nm by stirring the solution for 20 min at 1 400 r·min-1 and 75 ℃. The particles were uniformly distributed,and the microemulsion was clear and transparent without turbidity,phase separation and precipitation after the temperature test and acceleration test. Conclusion The preparation technology of lianzhang microemulsion is simple and stable.

目的探讨复方甘草酸苷注射液（SNMC）治疗妊娠晚期慢性乙肝患者对婴幼儿生长发育的影响。方法选择妊娠晚期慢性乙肝患者160例，分为SNMC组和思美泰注射液（SAM）对照组，每组80例。随访测量婴幼儿出生后6、12和24个月时的身高、体重、头围和胸围；同时采用贝利婴幼儿发展量表的智力发展指数（MDI）和运动发展指数（PDI）对婴幼儿的智力和运动状况进行评估。结果两组婴幼儿在6、12和24个月时的身高、体重、头围和胸围均数比较以及MDI和PDI均数比较，均无统计学差异（均P＞0.05）。结论复方甘草酸苷注射液治疗妊娠晚期慢性乙肝患者，对婴幼儿生长发育无明显影响。