BACKGROUND:The treatment of giant condyloma acuminatum in immunodeficient children remains a challenge. In immunodeficient children, human papillomavirus infection may progress to extensive condyloma acuminatum (CA. However, 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has shown favorable normal tissue-sparing properties in combination with high rates of lesion control. This case aims to highlight the safety and efficacy of ALA-PDT on giant condyloma acuminatum in an immunodeficient child induced by BCL11B mutation. METHODS:This report examines two affected siblings presenting with combined neurological and dermatological symptoms. Clinical assessments were conducted to evaluate intellectual development and skin manifestations. Genetic testing was performed to identify underlying mutations. The CA lesions were treated with the combined regimen of liquid nitrogen cryotherapy and ALA-PDT (90 mW/cm2, 20 min). RESULTS:The CA lesions achieved nearly complete resolution with an absence of notable side effects by ALA-PDT with cryotherapy. In addition, both siblings exhibited pronounced intellectual developmental disorder alongside atopic dermatitis-like lesions. Genetic analysis revealed a previously unreported pathogenic mutation in the BCL11B gene (c.1585G>T[p.Glu529*]) in both patients. The recommended diagnosis was IDDSFTA with concomitant Hyper-IgE Syndrome (HIES). Notably, the dermatological manifestations showed improvement following treatment with Dupilumab. CONCLUSION:This case provides evidence supporting the safety and potential advantages of ALA-PDT for CA in the immunodeficient pediatric settings. Meanwhile, these findings deepen the understanding of the clinical implications of the neurological gene BCL11B mutation (c.1585G>T[p.Glu529*]) in skin disorders.

BACKGROUND AND OBJECTIVES:Viral warts are benign proliferative skin lesions caused by the human papillomavirus (HPV) and are contagious among humans. Currently, there are no effective treatments to address the high recurrence rate of viral warts, presenting challenges in achieving their complete eradication. The aim of this study was to evaluate the efficacy and safety of curettage combined with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of recalcitrant acral warts. METHODS:Our study was carried out between July 2023 to June 2025, and the clinical data of 50 patients diagnosed with acral warts were retrospectively collected. Patients were assigned to the curettage group (n = 24) or the combination group (n = 26) based on whether they received photodynamic therapy after curettage. The clinical response effects, recurrence rate and adverse reactions of the two groups were observed and compared. RESULTS:The cure rate in the combination group was 80.8% (21/26), which was significantly higher than 45.8% (11/24) in curettage group. The recurrence rate in the combination group was 19.2% (5/26), which was lower than 54.2% (13/24) in curettage group (P < 0.05). After three months of follow-up, moderate pain was the main adverse reaction in both groups, and no systemic adverse reactions were observed. CONCLUSION:Our results suggest that curettage combined with ALA-PDT is promising as a safe and effective therapy for patients with recalcitrant acral warts.

目的:探讨并分析用红蓝光照射疗法联合薇诺娜舒敏保湿特护霜治疗面部激素依赖性皮炎的效果.方法:选取中国人民解放军陆军特色医学中心2019年2月至2020年2月期间收治的109例面部激素依赖性皮炎患者作为研究对象.按照随机数表法将其分为观察组(n=55)与对照组(n=54).用薇诺娜舒敏保湿特护霜对对照组患者进行治疗,用红蓝光照射疗法联合薇诺娜舒敏保湿特护霜对观察组患者进行治疗,然后比较两组患者的面部皮肤屏障功能指标、临床疗效及不良反应的发生率.结果:治疗后,观察组患者面部皮肤的表皮含水量和表皮油脂含量均高于对照组患者,其面部皮肤的经皮水分丢失量(TEWL)低于对照组患者,差异有统计学意义(P<0.05).观察组患者治疗的总有效率高于对照组患者,差异有统计学意义(P<0.05).治疗后,两组患者不良反应的发生率相比,差异无统计学意义(P>0.05).结论:用红蓝光照射疗法联合薇诺娜舒敏保湿特护霜对面部激素依赖性皮炎患者进行治疗能显著改善其病情,增强其面部皮肤的屏障功能,且治疗的安全性较高.

目的 探讨复方甘草酸苷和他克莫司软膏联合薇诺娜舒敏保湿修复霜治疗面部激素依赖性皮炎的临床效果.方法 收集于2017年12月～2019年12月期间收治的98例面部激素依赖性皮炎患者为研究对象,随机分为观察组(49例)和对照组(49例).对照组给予凡士林治疗,观察组采用复方甘草酸苷、他克莫司软膏、薇诺娜舒敏保湿修复霜联合治疗.对两组患者的总有效率、皮肤屏障功能、不良反应发生率、复发率进行统计对比.结果 观察组总有效率为89.80％(44/49),高于对照组患者的73.47％(36/49)(P<0.05).治疗后观察组患者的经皮水丢失(TEWL)低于对照组,角质层含水量、皮脂量高于对照组(P<0.05).治疗期间观察组、对照组不良反应发生率分别为18.37％(9/49)、12.24％(6/49),组间对比差异无统计学意义(P>0.05).随访6个月期间观察组复发率为8.17％(4/49),低于对照组的24.49％(12/49)(P<0.05).结论 复方甘草酸苷和他克莫司软膏联合薇诺娜舒敏保湿修复霜治疗面部激素依赖性皮炎的疗效显著,能够提升患者的皮肤屏障功能,降低复发率,治疗安全性良好.

目的:探讨重组人表皮生长因子凝胶联合红霉素软膏在激光祛斑祛痣术后创面修复的应用价值.方法:收集我院于2018年4月—2020年4月收治的激光祛斑祛痣术后患者104例,随机分为观察组和对照组,各52例.两组患者均进行激光祛斑祛痣术治疗,对照组术后给予红霉素软膏治疗,观察组术后给予重组人表皮生长因子凝胶联合红霉素软膏治疗.对比两组患者的临床疗效、创面修复相关指标及不良反应发生率.结果:观察组总有效率高于对照组(P<0.05).治疗后观察组创面愈合时间、结痂时间、痂壳脱落时间均短于对照组(P<0.05).两组不良反应总发生率比较无统计学差异(P>0.05).结论:重组人表皮生长因子凝胶联合红霉素软膏应用于激光祛斑去痣术后的创面修复疗效较好,能够加速患者的创面修复,且安全性好,应用价值肯定.

目的:探讨异维A酸联合盐酸氨酮戊酸光动力治疗中重度痤疮的疗效及对血清炎症因子的影响.方法:收集2018年3月—2020年3月本院门诊收治的中重度痤疮患者102例,随机分为对照组(51例,给予盐酸氨酮戊酸光动力治疗)、观察组(51例,对照组治疗基础上增加异维A酸治疗).治疗4周,观察两组患者的临床疗效并比较治疗前后血清炎症因子水平和不良反应发生率.结果:观察组治疗总有效率高于对照组(P<0.05).治疗后两组C反应蛋白(CRP)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平均降低,且观察组低于对照组(P<0.05).治疗期间两组不良反应发生率对比差异无统计学意义(P>0.05).结论:在盐酸氨酮戊酸光动力治疗基础上予以异维A酸治疗可提升中重度痤疮的疗效,降低机体的炎性因子水平,且不良反应发生率低.

Cutaneous blastomycosis is endemic to North America and is often caused by dimorphic fungi with spores that are inhaled, inoculated spores, or hyphae that infect immunosuppressed and healthy people. It is sporadic and described as a universal imitator with morphological manifestations as erythema, nodules, and ulcers. Our case demonstrated a 69-year-old female bitten by her pet dog who was then diagnosed with cutaneous blastomycosis through social history and detailed laboratory examinations. She experienced a prolonged failure with antibacterial treatment, negative stool and tissue culture, and chronic inflammatory cell infiltrates on tissue pathology. High-throughput sequencing was performed and showed evidence of Blastomyces dermatitidis aetiology. Photodynamic therapy combined with oral itraconazole was administered, and the patient recovered in a short time. Our case presents inoculated cutaneous blastomycosis and a treatment approach in which photodynamic therapy combined with oral itraconazole significantly reduced the duration of disease treatment and affords a promising choice for the treatment of cutaneous blastomycosis.

目的:探讨用CO2点阵激光联合光动力疗法治疗囊肿性痤疮的疗效及安全性.方法:将2018年3月至2020年3月期间陆军特色医学中心收治的92例囊肿性痤疮患者随机分为联合治疗组和常规治疗组(46例/组).为常规治疗组患者采用光动力疗法进行治疗,在此基础上为联合治疗组患者采用CO2点阵激光疗法进行治疗.治疗后,对比两组患者的临床疗效、皮损积分、DLQI评分、皮肤油脂含量和不良反应的发生率.结果:1)联合治疗组患者治疗的总有效率〔89.13％(41/46)〕高于常规治疗组患者治疗的总有效率〔71.74％(33/46)〕,P<0.05.2)治疗期间,联合治疗组患者、常规治疗组患者不良反应的发生率分别为15.22％(7/46)、8.70％(4/46),二者相比,P>0.05.3)治疗后,两组患者的皮损积分、皮肤油脂含量均较治疗前明显下降,其DLQI评分均较治疗前明显升高,P<0.05.治疗后,联合治疗组患者的皮损积分、皮肤油脂含量均低于常规治疗组患者,其DLQI评分高于常规治疗组患者,P<0.05.结论:用CO2点阵激光联合光动力疗法治疗囊肿性痤疮的疗效显著,能够改善患者的皮损症状,降低其皮肤油脂含量,提高其生活质量,且安全性较高.

目的 观察液氮冷冻联合光动力疗法(PDT)治疗儿童尖锐湿疣的疗效及复发率.方法 对23例尖锐湿疣患儿进行液氮冷冻联合PDT治疗,达到1个疗程后观察疣体清除情况,进行至少6个月的随访.结果 经过1个疗程PDT治疗后,患儿痊愈率达91.30％,复发率8.70％,未见严重不良反应.结论 液氮冷冻联合PDT治疗儿童尖锐湿疣简单、有效、创伤小、复发率低,是治疗儿童尖锐湿疣的一种有效的方法.

目的 观察果酸换肤治疗面部轻度痤疮患者应用针对性护理的实际效果.方法 选取我院近期接收的行果酸换肤治疗的200例面部轻度痤疮患者,将其随机均分为观察组与对照组.对照组行常规护理,观察组行针对性护理,对比其护理效果.结果 观察组患者的疗效以及满意度明显优于对照组患者,P<0.05.结论 果酸换肤治疗能够较好的改善面部寻常轻度痤疮患者的肤质,配合针对性护理方案,能够显著提高其治疗效果以及患者的满意度.

Objective: The purpose of this study was to evaluate the treatment outcome and safety of topical photodynamic therapy (PDT) with aminolevulinic acid (5-ALA) combined with surgical curettage for perianal condyloma acuminata. Background data: Condyloma acuminata is the most common sexually transmitted disease, with a high relapse rate, especially in the perianal area. The outcomes of many treatment methods for perianal genital warts are not satisfactory. Methods: In this study, 40 cases of perianal condyloma acuminata were treated with topical aminolevulinic acid photodynamic therapy (ALA-PDT) combined with curettage. First, the warts were removed with the patient under local anesthesia. The depth of the ablation and curettage reached the dermal layer. Then, the first session of PDT was performed after 2 days. Ten percent 5-ALA cream was applied to lesional skin with occlusive dressing for a 3-h incubation period and the lesions of warts were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity. The ALA-PDT was repeated after 1 and 3 weeks. Follow-up evaluation was performed at our outpatient clinic at 1 and 3 months after completion of therapy. Before treatment and at each follow-up visit, the lesions were photographed; the treatment outcome was evaluated as recurrence rate, and patient satisfaction was surveyed. Results: After three PDT sessions following surgical curettage, all 40 patients were cured and there was no recurrence at 1 month off treatment. At 3 months off treatment, six cases relapsed, corresponding to a recurrent rate of 15%. The satisfaction rate of patients was 100% at 1 month and 95% at 3 months after treatment. Conclusions: Combination of surgical curettage and topical PDT has been proven to be a safe and effective procedure, and may offer a wide clinical application for the treatment of perianal condyloma acuminata.

<正>目的:评价疣体刮除术联合局部光动力学疗法治疗肛周尖锐湿疣的疗效。方法:肛周尖锐湿疣患者24例,局部麻醉后,刮除肛周尖锐湿疣疣体,2d后再行局部光动力学治疗。将10%的5ALA乳剂浸润脱脂棉片覆盖新鲜创面,避光条件下封闭病灶3h。移除覆盖物,用

<正>目的:探讨刮除法联合ALA-光动力疗法治疗肛周巨大尖锐湿疣的疗效及护理要点。方法:肛周巨大尖锐湿疣患者12例,局部麻醉后用刮匙祛除巨大疣体,隔日采用局部ALA-光动力疗法治疗,1周后复诊,评价疣体

<正>目的:观察局部5-氨基酮戊酸(5-ALA)-光动力疗法(photodynamic therapy,PDT)治疗尿道口尖锐湿疣的疗效、安全性及复发情况。方法:男性尿道口尖锐湿疣患者21例,用10%5-ALA霜封包皮损3h后,采用波长635n

<正>痤疮是一种好发于青春期的毛囊皮脂腺的慢性炎症[1],常反复发作,明显影响患者的容貌及身心健康,尤其是重度痤疮,更是对患者的心理造成严重的影响。2009年7月～2010年2月,我科应用局部光动力联合红光治疗中、重度痤疮患者18例,临床效果满意,现报道如下。

OBJECTIVES To evaluate the safety and effect of systemic administration of photosensitizer Photocarcinorin (PsD-007) in the treatment of oral florid papillomatosis (OFP). BACKGROUND OFP is a rare and refractory disease characterized by multiple papillomatous lesions. The outcomes of many methods for OFP are not satisfactory. MATERIALS AND METHODS Photosensitizer Photocarcinorin (5 mg/kg) was intravenously injected into a 59-year-old woman with widespread OFP, and the lesions were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity and 106.2 J/cm(2) energy density. The therapy was performed once a month for 3 months in total. RESULTS After three courses, the small lesions disappeared, and the larger ones were reduced by ≥80%. The adverse effects were minimal. CONCLUSIONS Systemic PDT is an effective and successful treatment modality for OFP, especially in elderly patients.

<正>目的:观察艾拉-光动力疗法治疗尿道口尖锐湿疣的疗效。方法:尿道口尖锐湿疣患者45例,男性26例,女性19例;年龄21～81岁,平均年龄41.5岁。病程10d至5年。患者治疗前排空小便,应用0.1%新洁尔灭进行尿道口周围消毒,将新鲜配制艾拉药液约0.2ml轻插入尿道口1cm,使

痤疮是位于面部、胸背部的毛囊皮脂腺异常导致的皮肤疾患,痤疮丙酸杆菌和皮脂分泌在该病的发生中起重要作用.反复发作的炎性丘疹,严重影响患者的身心健康,甚至导致心理障碍,是临床上亟待解决的问题.局部光动力学治疗(photodynamic therapy,PDT),包括外用盐酸氨基酮戊酸(ALA)和一定的光源照射,可以明显改善炎性痤疮的临床表现[1,2].我们于2009年7月至2010年7月,应用局部光动力联合红光治疗重度炎性痤疮8例,临床效果满意,现报告如下.

OBJECTIVES:The purpose of this study was to observe the improvements of port-wine stains (PWSs) under photodynamic therapy (PDT) and to further evaluate the safety and efficacy of PDT in the dermatology clinic for the treatment of PWSs.METHODS:Total of 75 PWS patients were treated with PDT. The PWS lesions were exposed to the copper vapor laser after intravenous injection of photosensitizer (Photocarcinorin, PsD-007). The lesions were photographed before each session and the therapeutic effects were evaluated by physicians based on the improvements in color, thickness and area of the photographed lesions. A follow-up visit was carried out after 2 months. The improvement rates were classified into 5 grades for quantitation of the therapeutic effects. A decision of termination or continuation of the treatment was then made according to lesion changes.RESULTS:Patients with PWSs responded remarkably to PDT. The complete clinical remission rate was 57.33% and the effective rate was up to 94.67% in no more than four courses of treatment. Among the completely responded patients, 20.93% were treated with no more than two courses.CONCLUSION:PDT is safe and highly effective for the treatment of PWSs in the dermatology clinic.

中重度痤疮是一种毛囊皮脂腺的慢性炎症性皮肤疾病,具有丘疹、脓疱、结节、囊肿、瘢痕等多形态皮肤损害,影响患者生活质量,引发不同程度的心理和社会问题[1].传统的药物治疗效果因人而宜,长期服用易致耐药而且潜在不良反应[2-3];而外科手术治疗及皮损内注射其效果也不显著.光动力治疗(photodynamic therapy PDT)是结合光敏剂的激光治疗,近年来新兴的治疗中重度痤疮是一项新技术.本科自2007年2月至2008年2月以来,对中重度痤疮采用光动力治疗,皮损得到明显的改善,增强了患者的自信心,改善了患者的生活质量.现将护理体会报道如下.